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Cell Therapy and Regenerative Pain Medicine: Preclinical Studies

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Neuroimmune Interactions in Pain

Abstract

Mesenchymal stem cells (MSCs) and bone marrow stem cells (BMSCs) represent a novel therapy for chronic pain due to their immunomodulatory and neuroprotective properties. MSCs have shown long-lasting analgesic effects in preclinical models of pain that have been historically difficult to treat clinically. These conditions include neuropathic pain and cancer pain. The analgesic effects conferred by MSCs are mediated by a multitude of secreted mediators, including anti-inflammatory cytokines and growth factors, which can reduce neuroinflammation and pain signaling via neuroimmune interactions and further protect neurodegeneration. Extracellular vesicles secreted from MSCs are increasingly understood to mediate anti-inflammatory, pro-survival, regenerative, and analgesic effects previously attributed to MSCs themselves. These MSC-EVs may hold several advantages as therapeutics as compared to MSC cell therapy, though much remains to be learned. Importantly, there are multiple routes of administration for MSCs that can be catered to clinical needs. Overall, MSCs and their secretome provide a highly promising treatment modality to resolve some of the most prevalent and debilitating chronic pain conditions.

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Authors and Affiliations

  1. Department of Neurobiology, Duke University, Durham, NC, USA

    Toby Chen

  2. Center for Translational Pain Medicine, Departments of Anesthesiology and Cell Biology, Duke University, Durham, NC, USA

    Yul Huh

  3. Department of Anesthesiology, Duke University, Durham, NC, USA

    Andrew Breglio

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  1. Toby Chen
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  2. Yul Huh
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  3. Andrew Breglio
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Correspondence to Yul Huh .

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Editors and Affiliations

  1. Center for Translational Pain Medicine, Duke University Medical Center, Durham, NC, USA

    Ru-Rong Ji

  2. Pain Management and Neurosciences, Cleveland Clinic, Cleveland, OH, USA

    Jianguo Cheng

  3. Wellesley College, Wellesley, MA, USA

    Jasmine Ji

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Chen, T., Huh, Y., Breglio, A. (2023). Cell Therapy and Regenerative Pain Medicine: Preclinical Studies. In: Ji, RR., Cheng, J., Ji, J. (eds) Neuroimmune Interactions in Pain . Springer, Cham. https://doi.org/10.1007/978-3-031-29231-6_10

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