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Anti-epileptic drugs and prostate cancer-specific mortality compared to non-users of anti-epileptic drugs in the Finnish Randomized Study of Screening for Prostate Cancer
BackgroundDrugs with histone deacetylase inhibitory (HDACi) properties have shown to decrease prostate cancer (PCa) cell growth in vitro.
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Comprehensive interpretation of in vitro micronucleus test results for 292 chemicals: from hazard identification to risk assessment application
Risk assessments are increasingly reliant on information from in vitro assays. The in vitro micronucleus test (MNvit) is a genotoxicity test that...
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COVID-19 and antiepileptic drugs: an approach to guide practices when nirmatrelvir/ritonavir is co-prescribed
Management and dose adjustment are a major concern for clinicians in the absence of specific clinical outcome data for patients on antiepileptic...
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Chemogenetic Seizure Control with Clozapine and the Novel Ligand JHU37160 Outperforms the Effects of Levetiracetam in the Intrahippocampal Kainic Acid Mouse Model
Expression of inhibitory designer receptors exclusively activated by designer drugs (DREADDs) on excitatory hippocampal neurons in the hippocampus...
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C. elegans as a Potential Model for Acute Seizure-Like Activity
Conventional rodent models have provided invaluable tools for the discovery and characterization of antiepileptic drugs (AEDs). Nevertheless, around...
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Psychotic Disorders in Epilepsy: Do They Differ from Primary Psychosis?
Any attempt to compare the definitions of symptoms listed for “primary psychoses” with those adopted in studies of psychoses in patients with...
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Epilepsy, Diet, and Nutrition
Dietary nutrition plays a very important role in maintaining overall healthy well-being of an individual. As epilepsy is one of the most common...
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Recommendations for the treatment of epilepsy in adult and pediatric patients in Belgium: 2020 update
To guide health care professionals in Belgium in selecting the appropriate antiepileptic drugs (AEDs) for their epilepsy patients, a group of Belgian...
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Psychotropic and anti-epileptic drug use, before and after surgery, among patients with low-grade glioma: a nationwide matched cohort study
BackgroundLow-grade glioma (LGG) is a relatively rare type of brain tumour. The use of antidepressant, sedative and anti-epileptic drugs can reflect...
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Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy
PurposeTo estimate whether epilepsy patients with variant UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) alleles differ from their...
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Implications of BCRP modulation on PTZ-induced seizures in mice: Role of ko143 and metformin as adjuvants to lamotrigine
Blood–brain barrier (BBB) efflux transporters' overexpression hinders antiepileptic drug brain entry. Breast cancer resistance protein (BCRP) is a...
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Prognostic indicators of non-convulsive status epilepticus in intensive care unit
BackgroundTo determine the rate of non-convulsive status epilepticus with/without prominent motor phenomena (SE-PM/ NCSE) and predictive value of...
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Genotoxicity assessment: opportunities, challenges and perspectives for quantitative evaluations of dose–response data
Genotoxicity data are mainly interpreted in a qualitative way, which typically results in a binary classification of chemical entities. For more than...
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Mechanisms of Apoptosis in Drug-Resistant Epilepsy
Epilepsy is a chronic neurological disease with regular spontaneous seizures associated with neuroinflammatory, autoimmune, and neurodegenerative...
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Drug-Resistant Epilepsy and Gut-Brain Axis: an Overview of a New Strategy for Treatment
Drug-resistant epilepsy (DRE), also known as intractable epilepsy or refractory epilepsy, is a disease state with long-term poorly controlled...
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Determinants for Mediterranean diet adherence beyond the boundaries: a cross-sectional study from Sharjah, the United Arab Emirates
BackgroundSubstantial evidence embraced the nutrition competence of the Mediterranean diet (MD) as a healthy model for decreasing the risk of chronic...
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Selected Biomarkers of Oxidative Stress and Energy Metabolism Disorders in Neurological Diseases
Neurological diseases can be broadly divided according to causal factors into circulatory system disorders leading to ischemic stroke; degeneration...
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Idelalisib, a Selective Phosphatidylinositol-3-Kinase Inhibitor, Suppresses Pentylenetetrazole-Induced Convulsions in Wistar Rats
AbstractEpilepsy results from abnormal brain function and is one of the most common neurological diseases in the world. The...
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Epilepsy and COVID-19: Management of Patients and Optimization of Antiepileptic Treatment in the Pandemic
There are as yet no data pointing to any increase in the incidence of the novel coronavirus infection (COVID-19) or a more severe course of illness...
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Drug-Induced Tremors
Drug-induced tremors are common in clinical practice, but often underrecognized or misdiagnosed. There are a myriad of drugs that can cause or...