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Neural Sequences and the Encoding of Time
Converging experimental and computational evidence indicate that on the scale of seconds the brain encodes time through changing patterns of neural...
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Intersection of hippocampus and spinal cord: a focus on the hippocampal alpha-synuclein accumulation, dopaminergic receptors, neurogenesis, and cognitive function following spinal cord injury in male rats
BackgroundFollowing Spinal Cord Injury (SCI), innumerable inflammatory and degenerative fluctuations appear in the injured site, and even remotely in...
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The Effects of Chronic Marijuana Administration on 6-OHDA-Induced Learning & Memory Impairment and Hippocampal Dopamine and Cannabinoid Receptors Interaction in Male Rats
There are general inhibitory effects of exo-cannabinoids on dopamine-mediated behaviors. Many studies suggested the interaction between cannabinoid...
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Effects of Sleep Deprivation and Experience on Sleep Characteristics and Memory Formation Based on EEG Analysis
Sleep is believed to play an important role in cognitive functions. The underlying mechanisms of the relationship between the effects of waking...
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Fear Conditioning in Laboratory Rodents
An animal’s ability to avoid threat by learning about cues and places that predict the occurrence of a threat is pivotal for survival. This learning...
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Modulatory Role of Curcumin on Cobalt-Induced Memory Deficit, Hippocampal Oxidative Damage, Astrocytosis, and Nrf2 Expression
Chemical overexposure is a growing environmental risk factor for many medical issues. Cobalt toxicity from environmental, industrial, and medical...
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Exhaled Breath Analysis in Neurodegenerative Diseases
Neurodegenerative diseases are a group of pathological conditions demonstrating a variety in their clinical picture due to lesions of defined brain...
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Exhaled Breath Analysis in Neurodegenerative Diseases
Neurodegenerative diseases are a group of pathological conditions demonstrating a variety in their clinical picture due to lesions of defined brain...
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Effect of gastrodin against cognitive impairment and neurodegeneration in APP/PS1 mice via regulating gut microbiota–gut–brain axis
Gastrodin (Gas) has exhibited protective activity in neurological disorders. Here, we investigated the neuroprotective effect and potential...
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Prepubescent female rodents have enhanced hippocampal LTP and learning relative to males, reversing in adulthood as inhibition increases
Multiple studies indicate that adult male rodents perform better than females on spatial problems and have a lower threshold for long-term...
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k252a Inhibits H2S-Alleviated Homocysteine-Induced Cognitive Dysfunction in Rats
AbstractHomocysteine (Hcy) is a neurotoxicity amino acid that causes cognitive dysfunction. Hydrogen sulfide (H 2 S) is a neuroprotective gas...
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Regulation of Metabolic Health by an “Olfactory-Hypothalamic Axis” and Its Possible Implications for the Development of Therapeutic Approaches for Obesity and T2D
The olfactory system is responsible for the reception, integration and interpretation of odors. However, in the last years, it has been discovered...
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Black Seed Oil-Based Curcumin Nanoformulations Ameliorated Cuprizone-Induced Demyelination in the Mouse Hippocampus
Multiple sclerosis (MS) is a neurodegenerative disease characterized by the demyelination of nerves, axonal damage, and neuroinflammation. Cognition...
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The relevance between abnormally elevated serum ceramide and cognitive impairment in Alzheimer’s disease model mice and its mechanism
RationaleThe plasma ceramide levels in Alzheimer’s disease (AD) patients are found abnormally elevated, which is related to cognitive decline.
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A mouse model of ATRX deficiency with cognitive deficits and autistic traits
BackgroundATRX is an ATP-dependent chromatin remodeling protein with essential roles in safeguarding genome integrity and modulating gene expression....
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Complex Impairments to the Olfactory Sensory System in Schizophrenia
This article analyzes published data and shows that the functioning of the olfactory system is impaired in schizophrenia. Structural and functional...
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The citrus flavonoid “Nobiletin” impedes STZ-induced Alzheimer’s disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism
The prominence of autophagy in the modulation of neurodegenerative disorders has sparked interest to investigate its stimulation in Alzheimer's...
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Mdivi-1 Rescues Memory Decline in Scopolamine-Induced Amnesic Male Mice by Ameliorating Mitochondrial Dynamics and Hippocampal Plasticity
Memory loss, often known as amnesia, is common in the elderly population and refers to forgetting facts and experiences. It is associated with...
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Olfactory Dysfunction in Diabetic Rats is Associated with miR-146a Overexpression and Inflammation
Type 2 diabetes (T2D) is associated with cognitive decline and dementia. Both neurodegenerative conditions are characterized by olfactory dysfunction...
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Chemogenetic inhibition of subicular seizure-activated neurons alleviates cognitive deficit in male mouse epilepsy model
Cognitive deficit is a common comorbidity in temporal lobe epilepsy (TLE) and is not well controlled by current therapeutics. How epileptic seizure...
