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Circ_0058063 contributes to cisplatin-resistance of bladder cancer cells by upregulating B2M through acting as RNA sponges for miR-335-5p
Bladder cancer (BC) is one of the most common malignant tumors of the urinary system, and cisplatin (CDDP) is a critical chemical drug for the...
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Discerning the Prospects of miRNAs as a Multi-Target Therapeutic and Diagnostic for Alzheimer’s Disease
Although over the last few decades, numerous attempts have been made to halt Alzheimer’s disease (AD) progression and mitigate its symptoms, only a...
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Tenascin C in colorectal cancer stroma is a predictive marker for liver metastasis and is a potent target of miR-198 as identified by microRNA analysis
Background:Tumour stroma has important roles in the development of colorectal cancer (CRC) metastasis. We aimed to clarify the roles of microRNAs...
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Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance
Cancer is a complex disease displaying a variety of cell states and phenotypes. This diversity, known as cancer cell plasticity, confers cancer cells...
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Non-Coding RNAs and Neurodegenerative Diseases: Information of their Roles in Apoptosis
Apoptosis can be known as a key factor in the pathogenesis of neurodegenerative disorders. In disease conditions, the rate of apoptosis expands and...
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Epigenetic modulation of ferroptosis in cancer: Identifying epigenetic targets for novel anticancer therapy
Ferroptosis is a newly recognized form of oxidative-regulated cell death resulting from iron-mediated lipid peroxidation accumulation....
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Epigenetic regulation and therapeutic targets in the tumor microenvironment
The tumor microenvironment (TME) is crucial to neoplastic processes, fostering proliferation, angiogenesis and metastasis. Epigenetic regulations,...
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Circ-RAPGEF5 promotes intrahepatic cholangiocarcinoma progression by stabilizing SAE1 to facilitate SUMOylation
BackgroundIntrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with a poor prognosis. The underlying functions and mechanisms of...
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Drug resistance in ovarian cancer: from mechanism to clinical trial
Ovarian cancer is the leading cause of gynecological cancer-related death. Drug resistance is the bottleneck in ovarian cancer treatment. The...
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Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers
The serine-glycine-one-carbon (SGOC) metabolic pathway is critical for DNA methylation, histone methylation, and redox homeostasis, in addition to...
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Understanding the multifaceted role of miRNAs in Alzheimer’s disease pathology
Small non-coding RNAs (miRNAs) regulate gene expression by binding to mRNA and mediating its degradation or inhibiting translation. Since miRNAs can...
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A comprehensive review of SHP2 and its role in cancer
Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) is a non-receptor protein tyrosine phosphatase ubiquitously expressed mainly in the...
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Extracellular vesicles remodel tumor environment for cancer immunotherapy
Tumor immunotherapy has transformed neoplastic disease management, yet low response rates and immune complications persist as major challenges....
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Molecular mechanisms of microRNA-216a during tumor progression
MicroRNAs (miRNAs) as the members of non-coding RNAs family are involved in post-transcriptional regulation by translational inhibiting or mRNA...
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Regulation of cargo selection in exosome biogenesis and its biomedical applications in cancer
Extracellular vesicles (EVs), including exosomes, are increasingly recognized as potent mediators of intercellular communication due to their...
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MicroRNAs as the Critical Regulators of Forkhead Box Protein Family in Pancreatic, Thyroid, and Liver Cancers
The metabolism of human body is mainly regulated by the pancreas, liver, and thyroid using the hormones or exocrine secretions that affect the...
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MicroRNA-mediated reprogramming of glucose, fatty acid and amino acid metabolism in cancer
Cancer cells possess a unique metabolic phenotype, rewiring their metabolic pathways to support energy-intensive and biosynthetic requirements for...
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The important role of miR-1-3p in cancers
Cancer is a malignant tumor that seriously threatens human life and health. At present, the main treatment methods include surgical resection,...
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CircLPAR3 Acts as an Oncogene in Oral Squamous Cell Carcinoma Through Regulating the miR-643/HMGB2 Network
The malignant progression of oral squamous cell carcinoma (OSCC) has been confirmed to be mediated by a variety of factors, including circular RNA...
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The role of the methyltransferase METTL3 in prostate cancer: a potential therapeutic target
The incidence of prostate cancer (PCa), the most prevalent malignancy, is currently at the forefront. RNA modification is a subfield of the booming...
