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Baicalein inhibits IL-1β-induced extracellular matrix degradation with decreased MCP-1 expression in primary rat chondrocytes
Baicalein is a flavonoid extracted from the roots of Scutellaria baicalensis and Scutellaria lateriflora . This compound exerts various biochemical...
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Crosstalk between phytochemicals and inflammatory signaling pathways
Novel bioactive constituents from natural sources are actively being investigated. The phytochemicals in these phenolic compounds are believed to...
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Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans
As a functional amino acid (AA), L-arginine (Arg) serves not only as a building block of protein but also as an essential substrate for the synthesis...
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Paneth cell-derived iNOS is required to maintain homeostasis in the intestinal stem cell niche
BackgroundMammalian intestinal epithelium constantly undergoes rapid self-renewal and regeneration sustained by intestinal stem cells (ISCs) within...
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Involvement of IL-17 A/IL-17 Receptor A with Neutrophil Recruitment and the Severity of Coronary Arteritis in Kawasaki Disease
PurposeTo assess the role of the interleukin (IL)-17 A/IL-17 receptor A (IL-17RA) in Kawasaki disease (KD)-related coronary arteritis (CA).
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Effects of Sex Steroids on Innate and Adaptive Immunity
Estrogens and androgens are classically recognized as reproductive sex steroid hormones because of their well-documented effects on reproductive...
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Impact of microparticles released during murine systemic inflammation on macrophage activity and reactive nitrogen species regulation
Microparticles (MPs) packaged with numerous bioactive molecules are essential vehicles in cellular communication in various pathological conditions,...
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Transdermal deferoxamine administration improves excisional wound healing in chronically irradiated murine skin
BackgroundRadiation-induced skin injury is a well-known risk factor for impaired wound healing. Over time, the deleterious effects of radiation on...
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Nitric Oxide-Releasing Nanomaterials and Skin Infections
The free radical nitric oxide (NO) is an important endogenous molecule that controls several biological processes, ranging from the promotion of...
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Doxycycline Therapeutic Approach in Parkinson’s Disease and L-DOPA-Induced Dyskinesia
Parkinson’s disease is a chronic neurodegenerative disorder associated with the loss of dopamine neurons in the substantia nigra, for which there is...
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Inulae Flos has Anti-Depressive Effects by Suppressing Neuroinflammation and Recovering Dysfunction of HPA-axis
Depression is a debilitating mood disorder that causes persistent feelings of sadness, emptiness, and a loss of joy. However, the clinical efficacy...
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Parthenolide alleviates indomethacin-induced gastric ulcer in rats via antioxidant, anti-inflammatory, and antiapoptotic activities
Parthenolide (PTL) is a sesquiterpene lactone that occurs naturally. It demonstrates a variety of beneficial effects, such as antioxidant,...
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Nitric oxide interacts with cholinoceptors to modulate insulin secretion by pancreatic β cells
Dysfunction of the pancreatic β cells leads to several chronic disorders including diabetes mellitus. Several mediators and mechanisms are known to...
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Association of resveratrol with the suppression of TNF-α/NF-kB/iNOS/HIF-1α axis-mediated fibrosis and systemic hypertension in thioacetamide-induced liver injury
Chronic liver injury can lead to hepatic failure and the only available method of treatment would be liver transplantation. The link between...
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Melatonin modulates L-arginine metabolism in tumor-associated macrophages by targeting arginase 1 in lymphoma
L-Arginine metabolism plays a crucial role in determining the M1/M2 polarization of macrophages. The M1 macrophages express inducible nitric oxide...
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Association between endothelial nitric oxide synthase (NOS3) rs2070744 and the risk for migraine
Because nitric oxide could play an important role in the pathogenesis of migraine (suggested by experimental, neuropathological, biochemical, and...
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Trichinella spiralis cathepsin L induces macrophage M1 polarization via the NF-κB pathway and enhances the ADCC killing of newborn larvae
BackgroundDuring the early stages of Trichinella spiralis infection, macrophages predominantly undergo polarization to the M1-like phenotype,...
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Regulation of oxygen–glucose deprivation/reperfusion-induced inflammatory responses and M1-M2 phenotype switch of BV2 microglia by lobetyolin
To elucidate the protective mechanism of lobetyolin on oxygen–glucose deprivation/reperfusion (OGD/R)-induced damage in BV2 microglial cells. The...
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Dissecting the antidepressant effect of troxerutin: modulation of neuroinflammatory and oxidative stress biomarkers in lipopolysaccharide-treated mice
The role of neuroinflammation in the pathogenesis of depression has prompted the search for new antidepressants. Troxerutin, a bioflavonoid with...
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Nitric oxide debilitates the neuropathogenic schistosome Trichobilharzia regenti in mice, partly by inhibiting its vital peptidases
BackgroundAvian schistosomes, the causative agents of human cercarial dermatitis (or swimmer’s itch), die in mammals but the mechanisms responsible...
