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Biophysical mechanisms of myocardium sodium channelopathies
Genetic variants of gene SCN5A encoding the alpha-subunit of cardiac voltage-gated sodium channel Na v 1.5 are associated with various diseases,...
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SOCE in the cardiomyocyte: the secret is in the chambers
Store-operated Ca 2+ entry (SOCE) is an ancient and ubiquitous Ca 2+ signaling pathway that is present in virtually every cell type. Over the last two...
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Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B
Cancer stem cells (CSCs) are a subpopulation of cancer cells endowed with high tumorigenic, chemoresistant and metastatic potential. Nongenetic...
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Role of TRPM2 in brain tumours and potential as a drug target
Ion channels are ubiquitously expressed in almost all living cells, and are the third-largest category of drug targets, following enzymes and...
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Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group
The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant, and the heterogeneity of TBI patients and the...
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Coronary Vasoreactivity
The heart has the highest O2 consumption rate of all of the organs in the body. The resting left ventricle extracts ~70–80% of the O2 delivered by...
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Pan-cancer analyses reveal the genetic and pharmacogenomic landscape of transient receptor potential channels
Transient-receptor potential (TRP) channels comprise a diverse family of ion channels, which play important roles in regulation of intracellular...
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Cerebellar Granule Cell
The cerebellar granule cells are the most numerous neurons of the brain. They are also among those with the simplest structure by emitting just four...
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Calcium in Cell-Extracellular Matrix Interactions
In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular matrix (ECM), the largest calcium reservoir in animals. ECM...
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Understanding the “individual drug reaction” from the perspective of the interaction between probiotics and lovastatin in vitro and in vivo
BackgroundThe existence of the gut microbiota produces an “individual drug reaction.” As members of the intestinal microbiota, probiotics, although...
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Cyclic GMP Signaling
Guanosine 3′5′ cyclic monophosphate (cGMP) is synthesized by soluble guanylyl cyclase (sGC) when vascular smooth muscle is stimulated with nitric...
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Cardiac Ion Channels and Heart Rate and Rhythm
The excitability of the heart is a prerequisite for its function as a pump distributing blood throughout the body. Initiated in the sinoatrial node,...
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Channelopathies of voltage-gated L-type Cav1.3/α1D and T-type Cav3.1/α1G Ca2+ channels in dysfunction of heart automaticity
The heart automaticity is a fundamental physiological function in vertebrates. The cardiac impulse is generated in the sinus node by a specialized...
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Genetic Variation and Response to Neurocritical Illness: a Powerful Approach to Identify Novel Pathophysiological Mechanisms and Therapeutic Targets
Disease-specific therapeutic options for critically ill neurological patients are limited. The identification of new preventive, therapeutic, and...
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Hyper-IgE Syndrome due to an Elusive Novel Intronic Homozygous Variant in DOCK8
Rare, biallelic loss-of-function mutations in DOCK8 result in a combined immune deficiency characterized by severe and recurrent cutaneous...
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Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice
BackgroundAge > 65 years is a key risk factor for poor outcomes after human influenza infection. Specifically, in addition to respiratory disease,...
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1029 genomes of self-declared healthy individuals from India reveal prevalent and clinically relevant cardiac ion channelopathy variants
BackgroundThe prevalence and genetic spectrum of cardiac channelopathies exhibit population-specific differences. We aimed to understand the spectrum...
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Regulation of Ion Channel Function by Gas Molecules
Our understanding of the gaseous signaling molecules that play important roles in diverse physiological processes keeps expanding. These gas...