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Coronary Vasoreactivity

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Biology of Vascular Smooth Muscle

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Abstract

The heart has the highest O2 consumption rate of all of the organs in the body. The resting left ventricle extracts ~70–80% of the O2 delivered by the coronary circulation. Therefore, an increased myocardial O2 consumption depends primarily on increased coronary blood flow (CBF). Both under basal conditions and at increased cardiac activity, the CBF and the coronary vascular activities are regulated by coordinately activated mechanisms with the involvement of myogenic response, various endothelium-derived substances, local metabolites, and neuronal influence. The CBF is also constantly affected by the compressive force generated by the systolic and diastolic cycle of the heart, resulting in a predominant diastolic flow in the left ventricle and rendering the endocardium more vulnerable to ischemia. These unique characteristics of coronary circulation and the underlying mechanisms of the related changes in vasoreactivity will be discussed in this chapter.

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  1. Department of Physiology and Pathophysiology, Peking University Health Science Center, Bei**g, China

    Yuansheng Gao

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Gao, Y. (2022). Coronary Vasoreactivity. In: Biology of Vascular Smooth Muscle. Springer, Singapore. https://doi.org/10.1007/978-981-19-7122-8_17

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