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Contribution of Intravital Neuroimaging to Study Animal Models of Multiple Sclerosis
Multiple sclerosis (MS) is a complex and long-lasting neurodegenerative disease of the central nervous system (CNS), characterized by the loss of...
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Neurobiological Mechanism of Acupuncture Analgesia in Chronic Somatic Pain
Acupuncture reduces pain by activating specific areas called acupoints on the patient’s body. When these acupoints are fully activated, sensations of...
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The Roles of hnRNP Family in the Brain and Brain-Related Disorders
Heterogeneous nuclear ribonucleoproteins (hnRNPs) belong to a complex family of RNA-binding proteins that are essential to control alternative...
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Evidence of neuroinflammation and immunotherapy responsiveness in individuals with down syndrome regression disorder
BackgroundDown syndrome regression disorder is a symptom cluster consisting of neuropsychiatric regression without cause. This study evaluated the...
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Activation of Microglia and Macrophages in Neurodegenerative Diseases
Activation of innate and adaptive immune responses represents a hallmark of neurological disorders. In addition to reactive brain-resident myeloid...
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Nephelometry and Turbidimetry: Methods to Quantify Albumin and Immunoglobulins Concentrations in Clinical Neurochemistry
CSF concentrations of albumin and immunoglobulins (IgG, IgA, and IgM) are contemporary analyzed by fully automated, particle-enhanced turbidimetry or...
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Characterization of spinal cord tissue-derived extracellular vesicles in neuroinflammation
Extracellular vesicles (EVs) are released by all cells, can cross the blood–brain barrier, and have been shown to play an important role in cellular...
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Central regulation of stress-evoked peripheral immune responses
Stress-linked psychiatric disorders, including anxiety and major depressive disorder, are associated with systemic inflammation. Recent studies have...
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Transient receptor potential melastatin 3 dysfunction in post COVID-19 condition and myalgic encephalomyelitis/chronic fatigue syndrome patients
BackgroundMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe multisystemic condition associated with post-infectious onset,...
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Sex- and species-specific contribution of CD99 to T cell costimulation during multiple sclerosis
BackgroundDifferences in immune responses between women and men are leading to a strong sex bias in the incidence of autoimmune diseases that...
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Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients
BackgroundMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious disorder of unknown aetiology. While the pathomechanism of ME/CFS...
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Infections, Pandemics, and Sleep Disorders
Studies of the neurological symptoms and signs associated with the acute and late phases of infectious diseases are important in pandemic conditions....
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Improved Survival and Regeneration of Irradiated Mouse Neural Stem Cells after Co-Culturing with Non-Irradiated Mouse Neural Stem Cells or Mesenchymal Stem Cells from the Adipose Tissue
We studied the effect of neural stem cells (NSC) and mesenchymal stem cells (MSC) from mouse adipose tissue on survival, clonogenic activity, and...
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The brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation
Patients with COVID-19 can have a variety of neurological symptoms, but the active involvement of central nervous system (CNS) in COVID-19 remains...
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Impaired response of blood neutrophils to cell-death stimulus differentiates AQP4-IgG-seropositive NMOSD from MOGAD
BackgroundIn neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), neutrophils...
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MHCII-restricted T helper cells: an emerging trigger for chronic tactile allodynia after nerve injuries
Nerve injury-induced chronic pain has been an urgent problem for both public health and clinical practice. While transition to chronic pain is not an...
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Influence of the Gut Microbiota on Neuroendocrine-Immune Interactions
Body surfaces are colonized by an enormous array of microbes collectively referred to as the microbiota. In the past decade, there has been an...
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Inflammation-Mediated Responses in the Development of Neurodegenerative Diseases
Since its first description over a century ago, neurodegenerative diseases (NDDs) have impaired the lives of millions of people worldwide. As one of...
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Metabolomics in Depression: What We Learn from Preclinical and Clinical Evidences
Depression is one of the predominant common mental illnesses that affects millions of people of all ages worldwide. Random mood changes, loss of...
