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The NMDA Receptor System and Developmental Neurotoxicity
The NMDA receptor system has been implicated in the etiology of ketamine-induced developmental neurotoxicity. Prolonged ketamine exposure resulting...
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Increased immunoreactivity of glutamate receptors, neuronal nuclear protein and glial fibrillary acidic protein in the hippocampus of epileptic rats with fast ripple activity
Epilepsy is a neurological disorder in which an imbalance between excitatory and inhibitory transmission is observed. Glutamate is the principal...
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mGlu2/3 Receptor Antagonists as Rapid-Acting Antidepressants
Since the discovery of the robust and rapid-acting antidepressant effects of ketamine in patients with treatment-resistant depression, the...
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Metabotropic Glutamate Receptor 2 and Dopamine Receptor 2 Gene Expression Predict Sensorimotor Gating Response in the Genetically Heterogeneous NIH-HS Rat Strain
Disruption of sensorimotor gating causes “flooding” of irrelevant sensory input and is considered a congenital trait in several neurodevelopmental...
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DNA Methylation-Dependent Gene Expression Regulation of Glutamate Transporters in Cultured Radial Glial Cells
Exposure to xenobiotics has a significant impact in brain physiology that could be liked to an excitotoxic process induced by a massive release of...
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Map** Synaptic Connectivity in the Cerebellar Cortex Using RuBi-Glutamate Uncaging
Synaptic functional organization of excitatory and inhibitory inputs in neuronal microcircuits organizes dynamics and underlies learning processes....
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Linking Inflammation, Aberrant Glutamate-Dopamine Interaction, and Post-synaptic Changes: Translational Relevance for Schizophrenia and Antipsychotic Treatment: a Systematic Review
Evidence from clinical, preclinical, and post-mortem studies supports the inflammatory/immune hypothesis of schizophrenia pathogenesis. Less evident...
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Role of Ionotropic Glutamate Receptors in Neurodegenerative and Other Disorders
The central nervous system (CNS) plays host to some of the most unpredictable and complex disease states. While several hereditary and epigenetic...
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Optical Approaches for Modulating mGlu Receptor Activity
The metabotropic glutamate (mGlu) receptor family plays a diverse role in cellular function. However, differentiation of the specific contributions...
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Endogenous Modulators of NMDA Receptor Control Dendritic Field Expansion of Cortical Neurons
Impairments of N -methyl- D -aspartate receptor (NMDAR) activity have been implicated in several neuropsychiatric disorders, with pharmacological...
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The role of adenosine receptor ligands on inflammatory pain: possible modulation of TRPV1 receptor function
Chronic pain has a debilitating consequences on health and lifestyle. The currently available analgesics are often ineffective and accompanied by...
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The Glutamatergic System as a Target for the Development of New Pharmacological Treatments of Bipolar Disorder
Bipolar affective disorder is a relatively common psychiatric disorder that affects millions of people worldwide. Existing antidepressants and mood...
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RETRACTED ARTICLE: Bacopa monnieri attenuates glutamate-induced nociception and brain mitochondrial toxicity in Zebrafish
Bacopa monnieri L. (BM; Family: Scrophulariaceae), commonly known as Brahmi, is traditionally used as a nootropic agent. BM also exhibits significant...
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GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1/RIP3/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma
BackgroundGlaucoma, the major cause of irreversible blindness worldwide, is characterized by progressive degeneration of retinal ganglion cells...
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TRPC Channels Activated by G Protein-Coupled Receptors Drive Ca2+ Dysregulation Leading to Secondary Brain Injury in the Mouse Model
Canonical transient receptor potential (TRPC) non-selective cation channels, particularly those assembled with TRPC3, TRPC6, and TRPC7 subunits, are...
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Technologies for Screening of mGlu Receptor Allosteric Modulators
In recent years, modulation of metabotropic glutamate (mGlu) receptors has been explored in efforts for development of therapeutics, particularly for...
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The role of mGluR5 on the therapeutic effects of ketamine in Wistar rats
RationaleKetamine produces dissociative, psychomimetic, anxiolytic, antidepressant, and anesthetic effects in a dose dependent manner. It has a...
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The NMDA receptor antagonists memantine and ketamine as anti-migraine agents
Migraine is a debilitating disorder affecting females more frequently than males. There is some evidence that drugs targeting glutamate receptors:...
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A human stem cell-derived test system for agents modifying neuronal N-methyl-d-aspartate-type glutamate receptor Ca2+-signalling
Methods to assess neuronal receptor functions are needed in toxicology and for drug development. Human-based test systems that allow studies on...
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Sex differences in the medial prefrontal cortical glutamate system
BackgroundDysregulation in the prefrontal cortex underlies a variety of psychiatric illnesses, including substance use disorder, depression, and...
