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Associations between alcohol consumption and cardiovascular disease among long-term survivors of colorectal cancer: a population-based, retrospective cohort study
BackgroundThere is no evidence whether it is best to stop drinking alcohol at all or whether it is okay to drink a little in that light-to-moderate...
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Renin Angiotensin System (RAS): The Common Thread Between Cancer and Heart Failure
Cancer is a chronic illness that directly or indirectly affects many individuals worldwide. As the second most commonly diagnosed cancer worldwide,... -
Mitochondrial transplantation as a novel therapeutic strategy for cardiovascular diseases
Cardiovascular disease (CVD) is the leading cause of noncommunicable disease-related death worldwide, and effective therapeutic strategies against...
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Emerging applications of single-cell profiling in precision medicine of atherosclerosis
Atherosclerosis is a chronic, progressive, inflammatory disease that occurs in the arterial wall. Despite recent advancements in treatment aimed at...
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RNA Targeting and Gene Editing Strategies for Transthyretin Amyloidosis
Transthyretin (TTR) is a tetrameric protein synthesized primarily by the liver. TTR can misfold into pathogenic ATTR amyloid fibrils that deposit in...
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Renin Angiotensin System in the Pathophysiology of Diabetic Cardiomyopathy in Type 2 Diabetes
Type 2 diabetesDiabetes mellitus is associated with a high risk of heart failureHeart failure, in part because of its potential to induce impaired... -
Unraveling the Differentially Articulated Axes of the Century-Old Renin–Angiotensin–Aldosterone System: Potential Therapeutic Implications
Among numerous choices in cardiovascular therapies used for the management of hypertension and heart failure, drugs affecting the...
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Impact of a submaximal mono-articular exercise on the skeletal muscle function of patients with sickle cell disease
PurposeSickle cell disease (SCD) patients exhibit a limited exercise tolerance commonly attributed to anaemia, as well as hemorheological and...
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Chronic Digestive Chagas Disease
The digestive form of Chagas is characterized by alterations in motor, secretory, and absorptive functions of the gastrointestinal tract seen in... -
Regulation of endothelial function by cigarette smoke and next-generation tobacco and nicotine products
Cigarette smoking is the most important avoidable cardiovascular risk factor. It causes endothelial dysfunction and atherosclerosis and increases the...
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Acute mental stress-caused arterial stiffening can be counteracted by brief aerobic exercise
PurposeAcute mental stress (MS) causes an elevation in pulse wave velocity (PWV), an index of arterial stiffness. In contrast, aerobic exercise...
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Prevalence and risk factors of cardiovascular diseases and psychological distress among female scientists and technicians
This study aimed to explore the prevalence and risk factors of cardiovascular disease (CVD) and psychological distress among female scientists and...
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Interdependence of metals and its binding proteins in Parkinson’s disease for diagnosis
Metalloproteins utilizes cellular metals which plays a crucial function in brain that linked with neurodegenerative disorders. Parkinson’s disease...
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H2S Signals and Renin Angiotensin System in Cardiovascular Diseases
Hydrogen sulfideHydrogen sulfide (H2S) is recently recognized as the third gasotransmitter alongside with nitric oxide and carbon monoxide. H2S... -
MicroRNA-126 (MiR-126): key roles in related diseases
In eukaryotes such as humans, some non-coding single-stranded RNAs (ncRNAs) help to regulate the pre- and post-transcriptional expression of certain...
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Heart Valve Regeneration
The valves of the heart cannot regenerate spontaneously. Therefore, heart valve disease generally necessitates surgical repair or replacement of the... -
COVID-19
The global viral pandemic of COVID-19, caused by SARS-CoV-2 created an unprecedented demand for rapid diagnosis, containment, and treatment of the... -
Cell-to-Cell Crosstalk: A New Insight into Pulmonary Hypertension
Pulmonary hypertension (PH) is a disease with high pulmonary arterial pressure, pulmonary vasoconstriction, pulmonary vascular remodeling, and... -
Polypharmacology in Clinical Applications: Renal Polypharmacology
The urinary system, also known as the renal system or urinary tract, consists of the kidneys ,...