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AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma
BackgroundThe maintenance of complex dendritic arbors and synaptic transmission are processes that require a substantial amount of energy....
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Girl Power in Glaucoma: The Role of Estrogen in Primary Open Angle Glaucoma
Estrogen is essential in maintaining various physiological features in women, and a decline in estrogen levels are known to give rise to numerous...
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Melatonin Prevents Non-image-Forming Visual System Alterations Induced by Experimental Glaucoma in Rats
Glaucoma is a blindness-causing disease that involves selective damage to retinal ganglion cells (RGCs) and their axons. A subset of RGCs expressing...
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Soluble tumor necrosis factor-alpha-induced hyperexcitability contributes to retinal ganglion cell apoptosis by enhancing Nav1.6 in experimental glaucoma
BackgroundNeuroinflammation plays an important role in the pathogenesis of glaucoma. Tumor necrosis factor-alpha (TNF-α) is a major pro-inflammatory...
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Crosstalk between transforming growth factor β-2 and Autotaxin in trabecular meshwork and different subtypes of glaucoma
BackgroundElevated transforming growth factor (TGF)-β2 in aqueous humor (AH) has been suggested to contribute to trabecular meshwork (TM) fibrosis...
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Association of systemic inflammation indices with visual field loss progression in patients with primary angle-closure glaucoma: potential biomarkers for 3P medical approaches
RelevanceAccumulating evidence suggests a dysfunction of the para-inflammation in the retinal ganglion cell layer and the optic nerve head in...
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Carbonic Anhydrase Inhibitors in Ophthalmology: Glaucoma and Macular Oedema
Carbonic anhydrase inhibitors (CAIs) are commonly used pharmacologic agents. A myriad of CAI classes and inhibition mechanisms has been identified...
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Neuroprotection by WldS depends on retinal ganglion cell type and age in glaucoma
BackgroundEarly challenges to axonal physiology, active transport, and ultrastructure are endemic to age-related neurodegenerative disorders,...
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The Development and Evaluation of Phase Transition Microemulsion for Ocular Delivery of Acetazolamide for Glaucoma Treatment
The aim of this study was to develop microemulsion (ME) formulation with possible phase transition into liquid crystals upon ocular application to...
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An enhanced deep image model for glaucoma diagnosis using feature-based detection in retinal fundus
This paper proposes a deep image analysis–based model for glaucoma diagnosis that uses several features to detect the formation of glaucoma in...
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Analysis of Associations of Polymorphic Loci of the LOXL1 Gene with the Development of Primary Open-Angle Glaucoma in Women of the Central Chernozem Region of Russia
AbstractA replicative study of associations of the LOXL1 gene polymorphism with primary open-angle glaucoma (POAG) in the female population of the...
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Graph deep network for optic disc and optic cup segmentation for glaucoma disease using retinal imaging
The fundus imaging method of eye screening detects eye diseases by segmenting the optic disc (OD) and optic cup (OC). OD and OC are still challenging...
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Automated glaucoma screening method based on image segmentation and feature extraction
Glaucoma is a chronic disease that threatens eye health and can cause permanent blindness. Since there is no cure for glaucoma, early screening and...
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Automatic glaucoma screening using optic nerve head measurements and random forest classifier on fundus images
Glaucoma is an optic neuropathy that gradually steals the patient's sight by damaging the optic nerve head (which is responsible for transferring...
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RETRACTED ARTICLE: Bimatoprost-Loaded Silica Shell–Coated Nanoparticles-Laden Soft Contact Lenses to Manage Glaucoma: In Vitro and In Vivo Studies
Currently, glaucoma is managed by frequent instillation of bimatoprost eye drop therapy, which showed very poor ocular bioavailability. Contact lens...
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Transcorneal Electrical Stimulation Reduces Neurodegenerative Process in a Mouse Model of Glaucoma
Glaucoma is a neurodegenerative disease in which the retinal ganglion cell axons of the optic nerve degenerate concomitant with synaptic changes in...
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Preservation of optic nerve structure by complement inhibition in experimental glaucoma
Glaucoma is characterized by a progressive damage of the retina and the optic nerve. Despite a huge research interest, the exact pathomechanisms are...
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Chemo-informatics guided study of natural inhibitors targeting rho GTPase: a lead for treatment of glaucoma
Glaucoma, the most perilous disease leading to blindness is a result of optical neuropathy. Accumulation of aqueous humor in the posterior chamber...
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Genetic association between CDKN2B/CDKN2B-AS1 gene polymorphisms with primary glaucoma in a North Indian cohort: an original study and an updated meta-analysis
BackgroundVariants in CDKN2B / CDKN2B-AS1 have been reported to modulate glaucoma risk in several GWAS across different populations. CDKN2B / CDKN2A ...
