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Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS
The cerebrospinal fluid (CSF) is a complex solution that circulates around the CNS, and whose composition changes as a function of an animal’s...
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Sensory neuron dysfunction in orthotopic mouse models of colon cancer
Reports of neurological sequelae related to colon cancer are largely restricted to rare instances of paraneoplastic syndromes, due to autoimmune...
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A Calcium Imaging Approach to Measure Functional Sensitivity of Neurons
Pain associated with chemotherapy and radiation therapy is one of the most common reasons for discontinuation of these treatments and has a dramatic...
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Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation
The mRNA transcript of the human STMN2 gene, encoding for stathmin-2 protein (also called SCG10), is profoundly impacted by TAR DNA-binding protein...
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The combination of Hebbian and predictive plasticity learns invariant object representations in deep sensory networks
Recognition of objects from sensory stimuli is essential for survival. To that end, sensory networks in the brain must form object representations...
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Cognitive representations of intracranial self-stimulation of midbrain dopamine neurons depend on stimulation frequency
Dopamine neurons in the ventral tegmental area support intracranial self-stimulation (ICSS), yet the cognitive representations underlying this...
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Isolation and Differentiation of Neurons and Glial Cells from Olfactory Epithelium in Living Subjects
The study of psychiatric and neurological diseases requires the substrate in which the disorders occur, that is, the nervous tissue. Currently,...
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Efficacy of deep brain stimulation of the subthalamic nucleus versus globus pallidus internus on sensory complaints
Pain control after deep brain stimulation (DBS) in Parkinson’s disease (PD) remains unclear. Following six months, subthalamic (STN)-DBS reduced...
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Endothelin-1 enhances acid-sensing ion channel currents in rat primary sensory neurons
Endothelin-1 (ET-1), an endogenous vasoactive peptide, has been found to play an important role in peripheral pain signaling. Acid-sensing ion...
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Sigma-1 receptor activity in primary sensory neurons is a critical driver of neuropathic pain
The Sigma-1 receptor (σ 1 R) is highly expressed in the primary sensory neurons (PSNs) that are the critical site of initiation and maintenance of pain...
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Optogenetic Inhibition of Glutamatergic Neurons in the Dysgranular Posterior Insular Cortex Modulates Trigeminal Neuropathic Pain in CCI-ION Rat
In individuals with chronic neuropathic pain, the posterior insular cortex (PIC) has been found to exhibit increased glutamatergic activity, and the...
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A1 Adenosine Receptor Activation Inhibits P2X3 Receptor–Mediated ATP Currents in Rat Dorsal Root Ganglion Neurons
Purinergic signaling is involved in multiple pain processes. P2X3 receptor is a key target in pain therapeutics, while A1 adenosine receptor...
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Neurons upregulate PD-L1 via IFN/STAT1/IRF1 to alleviate damage by CD8+ T cells in cerebral malaria
BackgroundCerebral malaria (CM) is the most lethal complication of malaria, and survivors usually endure neurological sequelae. Notably, the...
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Temporal pain processing in the primary somatosensory cortex and anterior cingulate cortex
Pain is known to have sensory and affective components. The sensory pain component is encoded by neurons in the primary somatosensory cortex (S1),...
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AgRP neurons encode circadian feeding time
Food intake follows a predictable daily pattern and synchronizes metabolic rhythms. Neurons expressing agouti-related protein (AgRP) read out...
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From Neurons to Language and Speech: An Overview
In this chapter, we describe some of the basic principles of the human brain functionality, focusing on language and speech processes. After...
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CREB Participates in Paclitaxel-Induced Neuropathic Pain Genesis Through Transcriptional Activation of Dnmt3a in Primary Sensory Neurons
Chemotherapy-induced peripheral neuropathic pain (CIPNP) often occurs in cancer patients treated with antineoplastic drugs. Therapeutic management of...
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Contribution of Transglutaminase to the Induction and Maintenance of Long-Term Synaptic Potentiation in Neurons in the Common Snail
Previous studies have shown that the neurotransmitter serotonin is required for the successful formation of long-term potentiation in the terrestrial...
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Translating Colonic Sensory Afferent Peripheral Mechanosensitivity into the Spinal Cord Dorsal Horn
Sensory afferent signalling from the colon and rectum is relayed into the spinal cord. The spinal cord contains distinct neurocircuits that control...