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Long noncoding RNA SNHG1 alleviates high glucose-induced vascular smooth muscle cells calcification/senescence by post-transcriptionally regulating Bhlhe40 and autophagy via Atg10
AbstractLong noncoding RNAs (lncRNAs) are emerging regulators of vascular diseases, yet their role in diabetic vascular calcification/aging remains...
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Water Soluble Porphyrin for the Fluorescent Determination of Cadmium Ions
Porphyrins are highly conjugated molecules that perform wide variety of functions in biological systems. They absorb strongly in the visible region...
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Combined exposure to fine particulate matter and high glucose aggravates endothelial damage by increasing inflammation and mitophagy: the involvement of vitamin D
BackgroundCardiovascular diseases (CVDs) are related to particulate matter (PM 2.5 ) exposure. Researchers have not clearly determined whether...
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Sonochemical Synthesized Manganese Oxide Nanoparticles as Fluorescent Sensor for Selenium (IV) Quantification. Application to Food and Drink Samples
Manganese oxide nanoparticles (MnO Nps), sonochemical synthesized and characterized in our laboratory, are proposed as fluorescent sensor for...
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Histamine Recognition by Carbon Dots from Plastic Waste and Development of Cellular Imaging: Experimental and Theoretical Studies
The present work highlights the sustainable approach for the transformation of plastic waste into fluorescent carbon dots (CDs) through carbonization...
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Hippocampal LIMK1-mediated Structural Synaptic Plasticity in Neurobehavioral Deficits Induced by a Low-dose Heavy Metal Mixture
Humans are commonly exposed to the representative neurotoxic heavy metals lead (Pb), cadmium (Cd), and mercury (Hg). These three substances can be...
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Luminescent Pyrene-based Schiff base Receptor for Hazardous Mercury(II) Detection Demonstrated by Cell Imaging and Test Strip
Qualitative and quantitative analysis of mercury at concentration levels as low as parts per billion (ppb) is a basic and practical concern. The vast...
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The promotion action of AURKA on post-ischemic angiogenesis in diabetes-related limb ischemia
BackgroundDiabetes-related limb ischemia is a challenge for lower extremity amputation. Aurora Kinase A (AURKA) is an essential serine/threonine...
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An Application of a Schiff-Base Type Reaction in the Synthesis of a New Rhodamine-Based Hg(II)-Sensing Agent
A facile synthesis procedure, whereby 9-Anthraldehyde (AA) is coupled to aminated rhodamine (AR) via a Schiff base-type reaction, is reported. The...
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Highly sensitive retrospective determination of organophosphorous nerve agent biomarkers in human urine implemented in vivo in rabbit
Highly toxic organophosphorous nerve agents (OPAs) have been used in several armed conflicts and terror attacks in the last few decades. A new method...
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Hyperbaric Oxygenation Affecting Traumatic Brain Injury
Traumatic brain injury (TBI) is known to be accompanied by an increase in intracranial pressure (ICP) and, in some cases, by spontaneous generation...
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Dual Fluorescence-colorimetric Silver Nanoparticles Based Sensor for Determination of Olanzapine: Analysis in Rat Plasma and Pharmaceuticals
The present work describes a dual-readout assay for the determination of an antipsychotic drug olanzapine using Rhodamine B modified silver...
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Effects of Zinc, Mercury, or Lead on [3H]MK-801 and [3H]Fluorowillardiine Binding to Rat Synaptic Membranes
Glutamate (Glu) is considered the most important excitatory amino acid neurotransmitter in the mammalian Central Nervous System. Zinc (Zn) is...
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Facile Green Gamma Irradiation of Water Hyacinth Derived-Fluorescent Carbon Dots Functionalized Thiol Moiety for Metal Ion Detection
Fluorescent sensor-based carbon dots (CDs) have significantly developed for sensing metal ions because of their great physical and optical...
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Noninvasive Assessment of Blood Viscosity and Hematocrit
A method and system for noninvasive determination of blood viscosity and hematocrit to optimize prehospital correction of hypovolemia is addressed....
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Overexpression of E3 ubiquitin ligase Cbl attenuates endothelial dysfunction in diabetes mellitus by inhibiting the JAK2/STAT4 signaling and Runx3-mediated H3K4me3
BackgroundDiabetes mellitus (DM), a most common chronic disease, is featured with impaired endothelial function and bioavailability of nitric oxide...
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Thiourea Functionalised Receptor for Selective Detection of Mercury Ions and its Application in Serum Sample
A thiourea functionalised fluorescent probe 1-phenyl-3-(pyridin-4-yl)thiourea was synthesized and utilised as a fluorescent turn-on chemosensor for...
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Environmental Metal Exposure, Neurodevelopment, and the Role of Iron Status: a Review
Purpose of ReviewExposure to environmental metals, like lead (Pb), manganese (Mn), and methylmercury (Me-Hg), has consistently been implicated in...
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Transplant of fecal microbiota from healthy young mice relieves cognitive defects in late-stage diabetic mice by reducing metabolic disorders and neuroinflammation
Fecal microbiota transplant (FMT) is becoming as a promising area of interest for treating refractory diseases. In this study, we investigated the...
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NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy
BackgroundDiabetic nephropathy (DN) is one of the main complications of diabetes, and oxidative stress plays an important role in its progression....
