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Functional Annotation of Genes Differentially Expressed Between Primary Motor and Prefrontal Association Cortices of Macaque Brain
DNA microarray-based genome-wide transcriptional profiling and gene network analyses were used to characterize the molecular underpinnings of the...
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Molecular characterization and ligand binding specificity of the PDZ domain-containing protein GIPC3 from Schistosoma japonicum
BackgroundSchistosomiasis is a serious global health problem that afflicts more than 230 million people in 77 countries. Long-term mass treatments...
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Protein Phosphatase 1γ Isoforms Linked Interactions in the Brain
Posttranslational protein modifications, in particular reversible protein phosphorylation, are important regulatory mechanisms involved in cellular...
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Neurotrophin regulation of neural circuit development and function
Brain-derived neurotrophic factor (BDNF) — a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and...
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Axonal Transport
Axons are long slender cylindrical projections of neurons that enable these cells to communicate directly with other cells in the body over long...
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A common genetic network underlies substance use disorders and disruptive or externalizing disorders
Here we summarize evidence obtained by our group during the last two decades, and contrasted it with a review of related data from the available...
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Interaction of hepatitis B virus core protein with human GIPC1
Up to now, little is known about hepatitis B virus core protein (HBc) interactions with host-cell proteins, although such interactions might be...
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Genotype–phenotype relationship in three cases with overlap** 19p13.12 microdeletions
We describe the detailed clinical and molecular characterization of three patients (aged 7, 8 4/12 and 31 years) with overlap** microdeletions in...
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Mutations of GIPC3 cause nonsyndromic hearing loss DFNB72 but not DFNB81 that also maps to chromosome 19p
A missense mutation of Gipc3 was previously reported to cause age-related hearing loss in mice. Point mutations of human GIPC3 were found in two...
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Native human autoantibodies targeting GIPC1 identify differential expression in malignant tumors of the breast and ovary
BackgroundWe have been studying the native humoral immune response to cancer and have isolated a library of fully human autoantibodies to a variety...
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A human monoclonal autoantibody to breast cancer identifies the PDZ domain containing protein GIPC1 as a novel breast cancer-associated antigen
BackgroundWe have been studying the native autoimmune response to cancer through the isolation of human monoclonal antibodies that are cancer...
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Basic mechanisms for recognition and transport of synaptic cargos
Synaptic cargo trafficking is essential for synapse formation, function and plasticity. In order to transport synaptic cargo, such as synaptic...
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BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses
In the past 15 years numerous reports provided strong evidence that brain-derived neurotrophic factor (BDNF) is one of the most important modulators...
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Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma
IntroductionDuctal carcinoma in situ (DCIS) of the breast includes a heterogeneous group of preinvasive tumors with uncertain evolution. Definition...
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The semaphorins: versatile regulators of tumour progression and tumour angiogenesis
The semaphorins and their receptors, the neuropilins and the plexins, were originally characterized as constituents of the complex regulatory system...
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BDNF-mediated neurotransmission relies upon a myosin VI motor complex
Brain-derived neurotrophic factor (BDNF) has been implicated in higher-order cognitive functions and in psychiatric disorders such as depression and...
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Analysis of Polymorphic Variants of Gene GIPC1 CGG Repeats in Healthy Individuals and in Patients with Breast Cancer and Non-Small Cell Lung Cancer
The GIPC1 gene product promotes clustering of some transmembrane receptors, including those involved in carcinogenesis, and protects them against...