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Prodromal Parkinson's disease: hype or hope for disease-modification trials?
The ultimate goal in Parkinson's disease (PD) research remains the identification of treatments that are capable of slowing or even halting the...
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Industrial Perspective on Immunotherapy
Immunotherapy has revolutionised oncology and represents a fast-growing area of new drug products in anti-cancer therapy. Patients can now benefit...
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heredERA Breast Cancer: a phase III, randomized, open-label study evaluating the efficacy and safety of giredestrant plus the fixed-dose combination of pertuzumab and trastuzumab for subcutaneous injection in patients with previously untreated HER2-positive, estrogen receptor-positive locally advanced or metastatic breast cancer
BackgroundHER2-positive, estrogen receptor-positive breast cancer (HER2+, ER+ BC) is a distinct disease subtype associated with inferior response to...
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Reactions to learning a “not elevated” amyloid PET result in a preclinical Alzheimer’s disease trial
BackgroundThe experiences of biomarker-ineligible cognitively normal persons can inform trial conduct and the translation of preclinical Alzheimer’s...
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Ethical implications of epigenetics in the era of personalized medicine
Given the increasing research activity on epigenetics to monitor human diseases and its connection with lifestyle and environmental expositions, the...
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COVID-19: An Overview of Virology, Mutations, Pathology, Epidemiology, Diagnosis, Preventions, and Treatments
Since the first case of coronavirus disease (COVID-19) was reported in December 2019, it has become a pandemic, which is one of the most severe...
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Therapy of Parkinson’s Disease Subtypes
Early descriptions of subtypes of Parkinson’s disease (PD) are dominated by the approach of predetermined groups. Experts defined, from clinical...
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Epigenetics and ADHD: Reflections on Current Knowledge, Research Priorities and Translational Potential
Attention-deficit/hyperactivity disorder (ADHD) is a common and debilitating neurodevelopmental disorder influenced by both genetic and environmental...
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Association of Radiochemotherapy to Immunotherapy in unresectable locally advanced Oesophageal carciNoma—randomized phase 2 trial ARION UCGI 33/PRODIGE 67: the study protocol
BackgroundIn case of locally advanced and/or non-metastatic unresectable esophageal cancer, definitive chemoradiotherapy (CRT) delivering 50 Gy in 25...
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MicroRNAs as biomarkers for prostate cancer prognosis: a systematic review and a systematic reanalysis of public data
BackgroundReliable prognostic biomarkers to distinguish indolent from aggressive prostate cancer (PCa) are lacking. Many studies investigated...
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Amnestic MCI patients’ experiences after disclosure of their amyloid PET result in a research context
BackgroundBiomarkers such as amyloid imaging are increasingly used for diagnosis in the early stages of Alzheimer’s disease. Very few studies have...
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Discovery and validation of dominantly inherited Alzheimer’s disease mutations in populations from Latin America
BackgroundIn fewer than 1% of patients, AD is caused by autosomal dominant mutations in either the presenilin 1 ( PSEN1 ), presenilin 2 ( PSEN2 ), or amyl...
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The current issues and future perspective of artificial intelligence for develo** new treatment strategy in non-small cell lung cancer: harmonization of molecular cancer biology and artificial intelligence
Comprehensive analysis of omics data, such as genome, transcriptome, proteome, metabolome, and interactome, is a crucial technique for elucidating...
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Current Concepts and Controversies in the Management of REM Sleep Behavior Disorder
Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by dream enactment and the loss of muscle atonia during REM sleep, known as...
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The listed, delisted, and sustainability of therapeutic medicines for dementia patients: the study is specific to South Korea
The Dementia Management Act (DMA) came into effect on August 4, 2011, in South Korea. Diagnosis and medication were rapidly performed for dementia in...
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DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma
BackgroundLung cancer is a malignant tumor with the highest mortality worldwide. Abnormalities in the ubiquitin proteasome system are considered to...
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Multiorgans-on-a-Chip for Personalized Medicine
Microfluidic devices with regulated, dynamic microenvironments in which grown cells exhibit activities that mimic organ-level physiology are known as...
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Oxidative stress–mediated neuroinflammation in Alzheimer’s disease
Reactive oxygen species (ROS) are metabolic by-products that constitute an indispensable component of physiological processes, albeit their...
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Addressing the routine failure to clinically identify monogenic cases of common disease
Changes in medical practice are needed to improve the diagnosis of monogenic forms of selected common diseases. This article seeks to focus attention...