Search
Search Results
-
Local immune cell contributions to fracture healing in aged individuals – A novel role for interleukin 22
With increasing age, the risk of bone fractures increases while regenerative capacity decreases. This variation in healing potential appears to be...
-
Macrophage-enriched novel functional long noncoding RNAs LRRC75A-AS1 and GAPLINC regulate polarization and innate immune responses
IntroductionMacrophages (Mφs) are functionally dynamic immune cells that bridge innate and adaptive immune responses; however, the underlying...
-
Systemic immune response in young and elderly patients after traumatic brain injury
BackgroundTraumatic brain injury (TBI) is a leading cause of death and long-term disability worldwide. In addition to primary brain damage, systemic...
-
Neuroinflammation in Alzheimer’s disease: insights from peripheral immune cells
Alzheimer’s disease (AD) is a serious brain disorder characterized by the presence of beta-amyloid plaques, tau pathology, inflammation,...
-
Immunoglobulin-like receptors and the generation of innate immune memory
Host immunity is classically divided into “innate” and “adaptive.” While the former has always been regarded as the first, rapid, and...
-
An ocular Th1 immune response promotes corneal nerve damage independently of the development of corneal epitheliopathy
Proper sight is not possible without a smooth, transparent cornea, which is highly exposed to environmental threats. The abundant corneal nerves are...
-
Immune Checkpoint Therapy: A New Opportunity for Cancer Treatment
Due to improved understanding of the tumor biology and immunology, cancer immunotherapy has rapidly developed as a promising strategy to treat...
-
Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy
The cGAS-STING signaling pathway has emerged as a critical mediator of innate immune responses, playing a crucial role in improving antitumor...
-
Mouse models in COVID-19 research: analyzing the adaptive immune response
The emergence of SARS-CoV-2, the severe acute respiratory syndrome coronavirus type 2 causing the COVID-19 pandemic, resulted in a major necessity...
-
Impact of Doxorubicin and Docetaxel on Immune Checkpoint Expression in Colorectal Cancer: Insights into Chemotherapy Resistance Mechanisms
After chemotherapy, tumor cells tend to become more aggressive, making it challenging for natural and adaptive immune responses to fight them. This...
-
Immune Approaches in Tuberculosis Treatment
Tuberculosis (TB) is a dangerous infectious diseaseDiseaseInfectious caused by Mycobacterium tuberculosisMycobacterium tuberculosis (M. tb). Although...
-
Inhibition of autophagy-related protein 7 enhances anti-tumor immune response and improves efficacy of immune checkpoint blockade in microsatellite instability colorectal cancer
BackgroundThe efficacy of anti-PD-1 therapy is primarily hindered by the limited T-cell immune response rate and immune evasion capacity of tumor...
-
Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity
Adaptive immune repertoires are composed by the ensemble of B and T-cell receptors within an individual, reflecting both past and current immune...
-
Immune System and Mechanism of Immunomodulation
The immune system and its constituents establish an interface with the environment suitable for distinguishing “self” from “nonself” and then...
-
Immune Compartments and Extracellular Matrix Crosstalk Involved in Tumor Dissemination
Numerous precedents indicate that the immune system plays a dual role in preventing or allowing tumor development, progression, and dissemination....
-
The TLR/MyD88 signalling cascade in inflammation and gastric cancer: the immune regulatory network of Helicobacter pylori
Helicobacter pylori -induced chronic gastritis represents a well-established risk factor for gastric cancer (GC). However, the mechanism by which...
-
Whole tumour cell-based vaccines: tuning the instruments to orchestrate an optimal antitumour immune response
Immunotherapy, particularly those based on immune checkpoint inhibitors (ICIs), has become a useful approach for many neoplastic diseases. Despite...
-
Myc inhibition tips the immune balance to promote antitumor immunity
Aberrant expression of Myc is one of the most common oncogenic events in human cancers. Scores of Myc inhibitors are currently under development for...
-
Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer
Mismatch repair (MMR)-deficient cancer evolves through the stepwise erosion of coding homopolymers in target genes. Curiously, the MMR genes MutS...
-
How the immune response to the structural proteins of SARS-CoV-2 affects the retinal vascular endothelial cells: an immune thrombotic and/or endotheliopathy process with in silico modeling
Thrombotic events associated with SARS-CoV-2 at the vascular endothelium still remains unclear. The aim of the current study is to determine the...
