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Designing Efficient Cascade Reactions in Drug Discovery
This chapter focuses on the exploration and application of cascade reactions in the total synthesis of both biologically active natural products and...
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Diabetes and Cancer: The Epidemiological and Metabolic Associations
Diabetes mellitus, commonly known as diabetes, and cancer are two of the most common diseases plaguing the world today. According to the Centers for...
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Diabetes as one of the long-term COVID-19 complications: from the potential reason of more diabetic patients’ susceptibility to COVID-19 to the possible caution of future global diabetes tsunami
According to recent researches, people with diabetes mellitus (type 1 and 2) have a higher incidence of coronavirus disease 2019 (COVID-19), which is...
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Antidiabetics and Antilipemics from Nature
In recent years, diabetes and hyperlipidemia have become common in people from all parts of the world. Both these diseases are characterized by...
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Advances in Cancer Therapeutics: Potential Probiotics on Cancer Therapy
Cancer is known as the leading cause of human mortality. Several risk factors are associated with develo** cancer like genetic factors, immune...
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Resistin As a Biomarker and Applications to PreDiabetes
Resistin is a cysteine-rich protein, secreted from mature human adipocytes. Resistin has 108 amino acids. The resistin coding gene area is located on...
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A nationwide cohort study on diabetes severity and risk of Parkinson disease
There is growing evidence that patients with type 2 diabetes mellitus (DM) have an increased risk of develo** Parkinson’s disease (PD) and share...
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Polygenic subtype identified in ACCORD trial displays a favorable type 2 diabetes phenotype in the UKBiobank population
IntroductionWe previously identified a genetic subtype (C4) of type 2 diabetes (T2D), benefitting from intensive glycemia treatment in the Action to...
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Sex differences in type 2 diabetes: an opportunity for personalized medicine
Over the past several decades, substantial ground has been gained in understanding the biology of sex differences. With new mandates to include sex...
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Insulin Resistance and Cancer
Insulin is a peptide hormone that mediates both metabolic and mitogenic effects, and impaired insulin signaling leads to insulin resistance with...
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Osteoporosis
Osteoporosis is a systemic skeletal disease associated with an increased risk of fracture and characterized by reduced bone mass and qualitative...
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PPAR Modulation Through Posttranslational Modification Control
The peroxisome proliferator-activated receptors (PPAR) are transcription factors modulated by ligands and members of the nuclear receptor...
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Diabetes and Cancer
Diabetes mellitus and cancer are two heterogeneous diseases, incidence of both of which is increasing. Epidemiological evidences suggest that cancer...
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Natural Products as Nano-Antidiabetic Drugs
Natural products have emerged as promising candidates for the development of nano-antidiabetic drugs, presenting a novel approach to combat the...
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Polypharmacology in Clinical Applications: Metabolic Disease Polypharmacology
Metabolic diseases consisting of different groups of disorders are becoming increasingly prevalent and have a major impact on public health...