Abstract

Osteoporosis is a systemic skeletal disease associated with an increased risk of fracture and characterized by reduced bone mass and qualitative alterations in bone structure (in both macro- and micro-architecture). Cases of osteoporosis appearing after menopause (postmenopausal) or with advancing age (senile) are defined as primary. Juvenile osteoporosis is commonly used to indicate the forms of osteoporosis that are found in childhood and adolescence: These pathologies are mostly due to genetic mutations that can involve quantitative or qualitative alterations of the connective component of the bone (as in osteogenesis imperfecta) or an altered osteoblastic activity majorly affecting the trabecular bone. On the other hand, secondary osteoporosis can be caused by a large number of pathologies and drugs (Tables 1 and 2). Osteoporosis is not a disease affecting only women, indeed, about 20% of all hip fractures occur in males and the incidence of vertebral fractures is about half that of females. However, contrary to the prevalence, in affected males mortality and morbidity from vertebral and femoral fractures are higher than in affected females [1].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
EUR 29.95
Price includes VAT (Spain)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
EUR 117.69
Price includes VAT (Spain)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
EUR 145.59
Price includes VAT (Spain)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Abrahamsen B, Van Staa T, Ariely R, Olson M, Cooper C. Excess mortality following hip fracture: a systematic epidemiological review [Internet]. Osteoporos Int. 2009 [cited 2021 May 24];20:1633–1650. Available from: https://pubmed.ncbi.nlm.nih.gov/19421703/.

  2. WHO. WHO Study Group. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. World Health Organ Tech Rep Ser. 1994;1994(843):1–129.

    Google Scholar 

  3. Rossini M, Adami S, Bertoldo F, Diacinti D, Gatti D, Giannini S, et al. Linee guida per la diagnosi, la prevenzione ed il trattamento dell’osteoporosi. Reumatismo. 2016;68(1):1–42.

    Article  CAS  PubMed  Google Scholar 

  4. Pothuaud L, Carceller P, Hans D. Correlations between grey-level variations in 2D projection images (TBS) and 3D microarchitecture: applications in the study of human trabecular bone microarchitecture. Bone [Internet]. 2008 [cited 2021 May 26];42(4):775–87. Available from: https://pubmed.ncbi.nlm.nih.gov/18234577/.

  5. Hernlund E, Svedbom A, Ivergård M, Compston J, Cooper C, Stenmark J, et al. Osteoporosis in the European Union: medical management, epidemiology and economic burden: a report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos [Internet] 2013 [cited 2021 May 24];8(1–2). Available from: https://pubmed.ncbi.nlm.nih.gov/24113837/.

  6. Brunader R, Shelton DK. Radiologic bone assessment in the evaluation of osteoporosis [Internet], vol. 65, American Family Physician; 2002 [cited 2021 Apr 4]. Available from: www.aafp.org/afp.

  7. Rossini M, Adami S, Bertoldo F, Diacinti D, Gatti D, Giannini S, et al. Guidelines for the diagnosis, prevention and management of osteoporosis. Reumatismo. 2016;68(1):1–39.

    Article  CAS  PubMed  Google Scholar 

  8. Hernlund E, Svedbom A, Ivergård M, Compston J, Cooper C, Stenmark J, et al. Osteoporosis in the European Union: medical management, epidemiology and economic burden: a report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos [Internet]. 2013 [cited 2021 Apr 1];8(1–2). Available from: https://pubmed.ncbi.nlm.nih.gov/24113837/.

  9. Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S, et al. Clinician’s Guide to Prevention and Treatment of Osteoporosis. Osteoporos Int [Internet]. 2014 [cited 2021 Apr 8];25(10):2359–81. Available from: https://pubmed.ncbi.nlm.nih.gov/25182228/.

  10. Tsourdi E, Zillikens MC, Meier C, Body JJ, Gonzalez Rodriguez E, Anastasilakis AD, et al. Fracture risk and management of discontinuation of denosumab therapy: a systematic review and position statement by ECTS. J Clin Endocrinol Metab [Internet] 2021 [cited 2021 May 24];106(1):264–281. Available from: https://pubmed.ncbi.nlm.nih.gov/33103722/.

  11. Khundmiri SJ, Murray RD, Lederer E. PTH and vitamin D. Compr Physiol. 2016;6(2):561–601.

    Article  PubMed  Google Scholar 

  12. Gralow JR, Biermann JS, Farooki A, Fornier MN, Gagel RF, Kumar RN, et al. NCCN task force report: bone health in cancer care [Internet]. J Natl Compr Cancer Netw. 2009 [cited 2021 Apr 22];7. Available from: https://pubmed.ncbi.nlm.nih.gov/19555589/.

  13. McCloskey E, Paterson AH, Powles T, Kanis JA. Clodronate. Bone [Internet]. 2020 [cited 2021 Apr 8];143. Available from: https://pubmed.ncbi.nlm.nih.gov/33127577/.

  14. Agnusdei D, Iori N. Raloxifene: results from the MORE study. J Musculoskelet Neuronal Interact [Internet]. 2000;1(2):127–32. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15758505.

    CAS  PubMed  Google Scholar 

  15. Yavropoulou MP, Makras P, Anastasilakis AD. Bazedoxifene for the treatment of osteoporosis. Expert Opin Pharmacother [Internet]. 2019 [cited 2021 Apr 8];20(10):1201–10. Available from: https://www.tandfonline.com/doi/full/10.1080/14656566.2019.1615882.

  16. Rossini M, Adami G, Adami S, Viapiana O, Gatti D. Safety issues and adverse reactions with osteoporosis management [Internet], vol. 15. Expert Opinion on Drug Safety. Taylor and Francis Ltd; 2016 [cited 2021 Apr 8]. p. 321–2. Available from: https://pubmed.ncbi.nlm.nih.gov/26699669/.

  17. Cosman F, Crittenden DB, Adachi JD, Binkley N, Czerwinski E, Ferrari S, et al. Romosozumab treatment in postmenopausal women with osteoporosis. N Engl J Med [Internet]. 2016 [cited 2021 May 24];375(16):1532–43. Available from: https://pubmed.ncbi.nlm.nih.gov/27641143/.

  18. Cosman F, Crittenden DB, Ferrari S, Khan A, Lane NE, Lippuner K, et al. FRAME study: the foundation effect of building bone with 1 year of romosozumab leads to continued lower fracture risk after transition to denosumab. J Bone Miner Res [Internet] 2018 [cited 2021 May 24];33(7):1219–1226. Available from: https://pubmed.ncbi.nlm.nih.gov/29573473/.

  19. Saag KG, Petersen J, Brandi ML, Karaplis AC, Lorentzon M, Thomas T, et al. Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis. N Engl J Med [Internet]. 2017 [cited 2021 May 24];377(15):1417–27. Available from: https://pubmed.ncbi.nlm.nih.gov/28892457/.

  20. Chandra R V., Maingard J, Asadi H, Slater LA, Mazwi TL, Marcia S, et al. Vertebroplasty and kyphoplasty for osteoporotic vertebral fractures: what are the latest data? [Internet], vol. 39.American Journal of Neuroradiology; 2018 [cited 2021 Apr 10]. p. 798–806. Available from: https://pubmed.ncbi.nlm.nih.gov/29170272/.

  21. Fuggle NR, Kassim Javaid M, Fujita M, Halbout P, Dawson-Hughes B, Rizzoli R, et al. Fracture risk assessment and how to implement a fracture liaison service. In: 2021 [cited 2021 May 26]. p. 241–56. Available from: https://pubmed.ncbi.nlm.nih.gov/33347219/.

  22. Chadha M, Shingare A, Prasanth A, Chauhan P, Shah NF. Fracture liaison service: prevention by coordination [Internet], vol. 22. Ind J Endocrinol Metab. Wolters Kluwer Medknow Publications; 2018 [cited 2021 May 26]. p. 719–21. Available from: https://pubmed.ncbi.nlm.nih.gov/30766806/.

  23. Greco EA, Migliaccio S, Marcocci C, et al. Therapeutic appropriateness in osteoporosis. Endocrinologist. 2017;18:153–8.

    Google Scholar 

  24. Management of osteoporosis in postmenopausal women: the 2021 position statement of the North American Menopause Society. Menopause. 2021;28(9):973–97.

    Google Scholar 

  25. Angın E, Erden Z, Can F. The effects of clinical pilates exercises on bone mineral density, physical performance and quality of life of women with postmenopausal osteoporosis. J Back Musculoskelet Rehabil. 2015;28(4):849–58.

    Article  PubMed  Google Scholar 

  26. Küçükçakır N, Altan L, Korkmaz N. Effects of Pilates exercises on pain, functional status and quality of life in women with postmenopausal osteoporosis. J Bodyw Mov Ther. 2013;17(2):204–11.

    Article  PubMed  Google Scholar 

  27. Reid DM. Prevention of osteoporosis after breast cancer. Maturitas. 2009;64(1):4–8. https://doi.org/10.1016/j.maturitas.2009.07.008. Epub 2009 Aug 25. PMID: 19709826.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Montini, M., Pagani, A.A.M., Sporeni, S., Longhi, E.V. (2023). Osteoporosis. In: Longhi, E.V. (eds) Managing Psychosexual Consequences in Chronic Diseases. Springer, Cham. https://doi.org/10.1007/978-3-031-31307-3_30

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-31307-3_30

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-31306-6

  • Online ISBN: 978-3-031-31307-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Navigation