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Artificial Skin Models for Animal-Free Testing: 3D Skin Reconstruct Approach, a Journey in the Past Two Decades
Growing ethical concerns regarding the use of animals in research have managed to the creation of several alternative procedures based on the...
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Alpha-synuclein oligomers and small nerve fiber pathology in skin are potential biomarkers of Parkinson’s disease
The proximity ligation assay (PLA) is a specific and sensitive technique for the detection of αSyn oligomers (αSyn-PLA), early and toxic species...
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Investigating Interactions Between Endothelial Cells and Parasitized Red Blood Cells in Skin and Subcutaneous Tissue
In this chapter we present the methods for using biopsies of skin or subcutaneous tissue to examine the interactions between parasitized red blood...
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A model for estimating peak skin dose in CT
In interventional radiology patient care can be improved by accurately assessing peak skin dose (PSD) from procedures, as it is the main predictor...
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Current status of skin cancers with a focus on immunology and immunotherapy
Skin cancer is one of the most widespread cancers, with a significant global health effect. UV-induced DNA damage in skin cells triggers them to grow...
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Breathing new life into tissue engineering: exploring cutting-edge vascularization strategies for skin substitutes
Tissue-engineered skin substitutes (TESS) emerged as a new therapeutic option to improve skin transplantation. However, establishing an adequate and...
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Monitoring changing patterns in HER2 addiction by liquid biopsy in advanced breast cancer patients
BackgroundDuring targeted treatment, HER2-positive breast cancers invariably lose HER2 DNA amplification. In contrast, and interestingly, HER2...
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Effects of psoriasis and psoralen exposure on the somatic mutation landscape of the skin
Somatic mutations are hypothesized to play a role in many non-neoplastic diseases. We performed whole-exome sequencing of 1,182 microbiopsies...
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Robot-Assisted Brain Biopsy
Stereotactic biopsy is a routine neurosurgical procedure. Although a robot was first used to perform a stereotactic biopsy in 1985, little on...
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EXIT from TRansrectal prostate biopsies (TREXIT): sepsis rates of transrectal biopsy with rectal swab culture guided antimicrobials versus freehand transperineal biopsy
BackgroundTransrectal prostate biopsy (TRUSBx) holds a risk of prostate biopsy related sepsis. We discuss our step-wise strategies aiming to reduce...
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Fluid and Biopsy Based Biomarkers in Parkinson’s Disease
Several advances in fluid and tissue-based biomarkers for use in Parkinson’s disease (PD) and other synucleinopathies have been made in the last...
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Combining germline, tissue and liquid biopsy analysis by comprehensive genomic profiling to improve the yield of actionable variants in a real-world cancer cohort
BackgroundComprehensive next-generation sequencing is widely used for precision oncology and precision prevention approaches. We aimed to determine...
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miR-21 Expressed by Dermal Fibroblasts Enhances Skin Wound Healing Through the Regulation of Inflammatory Cytokine Expression
The management of skin wound healing is still a challenge. MicroRNA-21 (miR-21) has been reported to play important roles in wound repair; however,...
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Genome-wide DNA methylation of lesional and peri-lesional skin in vitiligo: a comparative and integrated analysis of multi-omics in Chinese population
Several studies have emphasized the role of DNA methylation in vitiligo. However, its profile in human skin of individuals with vitiligo remains...
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Optical Techniques for Treatment and Tissue Evaluation Using Skin Models for Preclinical Studies
Cancer is one of the most incident diseases in the world, and skin cancer is the most prevalent type, making it a public health problem. New...
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Transperineal magnetic resonance imaging targeted biopsy versus transrectal route in the detection of prostate cancer: a systematic review and meta-analysis
PurposeMagnetic resonance imaging (MRI) has deeply altered the prostate biopsy strategy to detect prostate cancer. However, it is still debatable...
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Sentinel Lymph Node Biopsy in Breast Cancer
Lymphatic metastasis is a strong predictor of poor outcome in breast cancer patients. Most often, lymphatic metastasis occurs through the axillary...
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Molecular characterization and whole-genome sequencing of Corynebacterium diphtheriae causing skin lesion
We present a case of skin lesion caused by nontoxigenic Corynebacterium diphtheriae . Genomic taxonomy analyses corroborated the preliminary...
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Liquid Biopsies Methods and Protocols
This book analyzes liquid biopsy applications in cancer and other diseases. Chapters guide readers through the latest technologies and analysis...
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Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models
Cellular senescence is known to play a role in age-related skin function deterioration which potentially influences longevity. Here, a two-step...
