Abstract
Cancer is one of the most incident diseases in the world, and skin cancer is the most prevalent type, making it a public health problem. New treatments and optimization of existent protocols are always desired to prolong or improve human life. The better way to avoid complications for patients with skin cancer is by providing efficient diagnosis and accessible treatment. For this purpose, it is indispensable to perform preclinical trials for the new therapies’ developments and new diagnosis methods. The standardization of skin tumor models in animals and the techniques to explore treatment response is what can make the translational to humans quicker. This chapter summarizes the main different animal models including chorioallantoic membrane and skin lesions induction procedures in this research area as well as the techniques to evaluate and monitor the treatment’s efficiency and optical techniques that help the diagnosis and understanding of biological samples.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Andersson-Engels S, Johansson J, Svanberg K, Svanberg S (1991) Fluorescence imaging and point measurements of tissue: applications to the demarcation of malignant tumors and atherosclerotic lesions from normal tissue. Photochem Photobiol 53:807–814. https://doi.org/10.1111/j.1751-1097.1991.tb09895.x
Andrade CT, Vollet-Filho JD, Salvio AG et al (2014) Identification of skin lesions through aminolaevulinic acid-mediated photodynamic detection. Photodiagn Photodyn Ther 11:409–415. https://doi.org/10.1016/j.pdpdt.2014.05.006
Ang M, Tan ACS, Cheung CMG et al (2018) Optical coherence tomography angiography: a review of current and future clinical applications. Graefes Arch Clin Exp Ophthalmol 256:237–245. https://doi.org/10.1007/s00417-017-3896-2
Atkins P (2006) Fisico Quimica, 8th edn. LCT, Rio de Janeiro
Avci P, Sadasivam M, Gupta A et al (2013) Animal models of skin disease for drug discovery. Expert Opin Drug Discov 8:331–355. https://doi.org/10.1517/17460441.2013.761202
Ayuso M, Buyssens L, Stroe M et al (2020) The neonatal and juvenile pig in pediatric drug discovery and development. Pharmaceutics 13:44. https://doi.org/10.3390/pharmaceutics13010044
Balke M, Neumann A, Kersting C et al (2010) Morphologic characterization of osteosarcoma growth on the chick chorioallantoic membrane. BMC Res Notes 3:58. https://doi.org/10.1186/1756-0500-3-58
Bilous M, Dowsett M, Hanna W et al (2003) Current perspectives on HER2 testing: a review of national testing guidelines. Mod Pathol 16:173–182. https://doi.org/10.1097/01.MP.0000052102.90815.82
Calabro K, Curtis A, Galarneau J-R et al (2011) Gender variations in the optical properties of skin in murine animal models. J Biomed Opt. https://doi.org/10.1117/1.3525565
Coricovac D, Dehelean C, Moaca E-A et al (2018) Cutaneous melanoma – a long road from experimental models to clinical outcome: a review. Int J Mol Sci 19:1566. https://doi.org/10.3390/ijms19061566
De Beule PAA, Dunsby C, Galletly NP et al (2007) A hyperspectral fluorescence lifetime probe for skin cancer diagnosis. Rev Sci Instrum 78:123101. https://doi.org/10.1063/1.2818785
Detmar M, Velasco P, Richard L et al (2000) Expression of vascular endothelial growth factor induces an invasive phenotype in human squamous cell carcinomas. Am J Pathol 156:159–167. https://doi.org/10.1016/S0002-9440(10)64715-3
Gober MD, Bashir HM, Seykora JT (2013) Reconstructing skin cancers using animal models. Cancer Metastasis Rev 32:123–128. https://doi.org/10.1007/s10555-012-9410-8
Godin B, Touitou E (2007) Transdermal skin delivery: predictions for humans from in vivo, ex vivo and animal models. Adv Drug Deliv Rev 59:1152–1161
González-Vázquez P, Larrañeta E, McCrudden MTC et al (2017) Transdermal delivery of gentamicin using dissolving microneedle arrays for potential treatment of neonatal sepsis. J Control Release. https://doi.org/10.1016/j.jconrel.2017.07.032
Gudjonsson JE, Johnston A, Dyson M et al (2007) Mouse models of psoriasis. J Invest Dermatol 127:1292–1308. https://doi.org/10.1038/sj.jid.5700807
Hawighorst T, Skobe M, Streit M et al (2002) Activation of the Tie2 receptor by Angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth. Am J Pathol 160:1381–1392. https://doi.org/10.1016/S0002-9440(10)62565-5
Hussein IH, Raad M (2015) Once upon a microscopic slide: the story of histology. J Cytol Histol 06. https://doi.org/10.4172/2157-7099.1000377
Ishida N, Watanabe D, Mizutani K et al (2009) Heating increases protoporphyrin IX production in normal skin after delivery of 5-aminolevulinic acid by iontophoresis. Photodermatol Photoimmunol Photomed 25:333–334. https://doi.org/10.1111/j.1600-0781.2009.00461.x
Ishikawa-ankerhold HC, Ankerhold R, Drummen GPC et al (2012) Advanced fluorescence microscopy techniques – FRAP, FLIP, FLAP, FRET and FLIM. Molecules 17:4047–4132. https://doi.org/10.3390/molecules17044047
Jadidi-Niaragh F, Atyabi F, Rastegari A et al (2017) CD73 specific siRNA loaded chitosan lactate nanoparticles potentiate the antitumor effect of a dendritic cell vaccine in 4T1 breast cancer bearing mice. J Control Release 246:46–59. https://doi.org/10.1016/j.jconrel.2016.12.012
Jaque D, Martínez Maestro L, del Rosal B et al (2014) Nanoparticles for photothermal therapies. Nanoscale 6:9494–9530. https://doi.org/10.1039/c4nr00708e
Jones TA, Jones SM, Paggett KC (2006) Emergence of hearing in the chicken embryo. J Neurophysiol 96:128141
Jung EC, Maibach HI (2015) Animal models for percutaneous absorption. J Appl Toxicol 35:1–10. https://doi.org/10.1002/jat.3004
Khavkin J, Ellis DAF (2011) Aging skin: histology, physiology, and pathology. Facial Plast Surg Clin North Am 19:229–234
Khurana D, Martin EA, Kasperbauer JL et al (2001) Characterization of a spontaneously arising murine squamous cell carcinoma (SCC VII) as a prerequisite for head and neck cancer immunotherapy. Head Neck 23:899–906. https://doi.org/10.1002/hed.1130
Kleinerman R, Whang TB, Bard RL, Marmur ES (2012) Ultrasound in dermatology: principles and applications. J Am Acad Dermatol 67:478–487. https://doi.org/10.1016/j.jaad.2011.12.016
Kondo S, Asano M, Suzuki H (1993) Significance of vascular endothelial growth factor/vascular permeability factor for solid tumor growth, and its inhibition by the antibody. Biochem Biophys Res Commun 194:1234–1241. https://doi.org/10.1006/bbrc.1993.1955
Konger RL, Derr-Yellin E, Ermatov N et al (2019) The PPARγ agonist rosiglitazone suppresses syngeneic mouse SCC (squamous cell carcinoma) tumor growth through an immune-mediated mechanism. Molecules 24:2192. https://doi.org/10.3390/molecules24112192
Korinfsky JP, Plapler H, Moreno TR et al (2014) Induction of neoplastic cells in rat skin. Acta Cir Bras 29:104–110. https://doi.org/10.1590/S0102-86502014000200006
Kumar GL, Kiernan JA, (editors). (2010) Special Stains and H&E [Internet]. 2nd ed. Vol. 14, Connection. Carpinteria, California: Dako. 158 p. Available from: https://www.agilent.com/cs/library/technicaloverviews/public/08066_special_stains_eduguide.pdf
Kumer GL, Kiernan JA (2010) Special stains and H&E. Connection 14:volume 14
Langer J (1969) Laser-Tissue Interactions. Ann Phys 54:258. ISBN 9783540721918
Lawton S (2019) Skin 1: the structure and functions of the skin. Nurs Times 115:30–33
Miller JP, Habimana-Griffin L, Edwards TS, Achilefu S (2017) Multimodal fluorescence molecular imaging for in vivo characterization of skin cancer using endogenous and exogenous fluorophores. J Biomed Opt 22:066007. https://doi.org/10.1117/1.JBO.22.6.066007
Nadejda R, **zhong Z (2009) Photothermal ablation therapy for cancer based on metal nanostructures. Sci China Ser B-Chem 52:1559–1575
Nowak-Sliwinska P, Ballini JP, Wagnières G, Van Den Bergh H (2009) Processing of fluorescence angiograms for the quantification of vascular effects induced by anti-angiogenic agents in the CAM model. Microvasc Res 79:21–28
Nowak-Sliwinska P, van Beijnum JR, van Berkel M et al (2010) Vascular regrowth following photodynamic therapy in the chicken embryo chorioallantoic membrane. Angiogenesis 13:281–292. https://doi.org/10.1007/s10456-010-9185-x
Nwaneshiudu A, Kuschal C, Sakamoto FH et al (2012) Introduction to confocal microscopy. J Invest Dermatol 132:1–5. https://doi.org/10.1038/jid.2012.429
Olsen J, Holmes J, Jemec GBE (2018) Advances in optical coherence tomography in dermatology – a review. J Biomed Opt 23:1. https://doi.org/10.1117/1.JBO.23.4.040901
Oltulu P, Ince B, Kökbudak N et al (2018) Measurement of epidermis, dermis, and total skin thicknesses from six different body regions with a new ethical histometric technique. Turk Plast Rekonstruktif Estet Cerrahi Derg. https://doi.org/10.4103/tjps.tjps_2_17
Ozaslan M, Karagoz ID, Kilic IH, Guldur ME (2011) Ehrlich ascites carcinoma. Afr J Biotechnol 10:2375–2378. https://doi.org/10.4314/ajb.v10i13
Permana AD, Tekko IA, McCrudden MTC et al (2019) Solid lipid nanoparticle-based dissolving microneedles: a promising intradermal lymph targeting drug delivery system with potential for enhanced treatment of lymphatic filariasis. J Control Release. https://doi.org/10.1016/j.jconrel.2019.10.004
Prasad PN (2003) Introduction to biophotonics, Hoboken
Requena MB, Vollet Filho JD, Barboza de Nardi A et al (2019) Topical and intradermal delivery of PpIX precursors for photodynamic therapy with intense pulsed light on porcine skin model. Lasers Med Sci. https://doi.org/10.1007/s10103-019-02771-y
Ribatti D (2016) The chick embryo chorioallantoic membrane (CAM). A multifaceted experimental model. Mech Dev 141:70–77. https://doi.org/10.1016/j.mod.2016.05.003
Richards-Kortum R, Rava RP, Petras RE et al (1991) Spectroscopic diagnosis of colonic dysplasia. Photochem Photobiol 53:777–786. https://doi.org/10.1111/j.1751-1097.1991.tb09892.x
Station CA, Stribbling SM, Tazzyman S et al (2004) Current methods for assaying angiogenesis in vitro and in vivo. Int J Exp Pathol 85:233–248
Steiner R (1992) Angiostatic activity of anticancer agents in the chick embryo chorioallantoic membrane assay. EXS 61:449–454
Su M, Han Q, Yan X et al (2021) A supramolecular strategy to engineering a absorbing nano-J-aggregate for efficient photothermal therapy. ACS Nano. https://doi.org/10.1021/acsnano.0c09993
Tomayko MM, Reynolds CP (1989) Determination of subcutaneous tumor size in athymic (nude) mice. Cancer Chemother Pharmacol 24:148–154. https://doi.org/10.1007/BF00300234
Wei JCJ, Edwards GA, Martin DJ et al (2017) Allometric scaling of skin thickness, elasticity, viscoelasticity to mass for micro-medical device translation: from mice, rats, rabbits, pigs to humans. Sci Rep 7:15885. https://doi.org/10.1038/s41598-017-15830-7
Wilson BC, Patterson MS (2008) The physics, biophysics and technology of photodynamic therapy. Phys Med Biol 53:R61–R109. https://doi.org/10.1088/0031-9155/53/9/R01
Wood GS, Warnke R (1981) Suppression of endogenous avidin-binding activity in tissues and its relevance to biotin-avidin detection systems. J Histochem Cytochem 29:1196–1204. https://doi.org/10.1177/29.10.7028859
Workman P, Aboagye EO, Balkwill F et al (2010) Guidelines for the welfare and use of animals in cancer research. Br J Cancer 102:1555–1577. https://doi.org/10.1038/sj.bjc.6605642
Yoon JH, Yoon HE, Kim O et al (2012) The enhanced anti-cancer effect of hexenyl ester of 5-aminolaevulinic acid photodynamic therapy in adriamycin-resistant compared to non-resistant breast cancer cells. Lasers Surg Med 44:76–86. https://doi.org/10.1002/lsm.21154
Zamora-Rojas E, Aernouts B, Garrido-Varo A et al (2013) Optical properties of pig skin epidermis and dermis estimated with double integrating spheres measurements. Innov Food Sci Emerg Technol 20:343–349. https://doi.org/10.1016/j.ifset.2013.06.008
Zendzian RP (2000) Dermal absorption of pesticides in the rat. AIHAJ Am Ind Hyg Assoc 61:473–483. https://doi.org/10.1080/15298660008984558
Zhang Y, Shen TT, Kirillov AM et al (2016) NIR light/H2O2-triggered nanocomposites for a highly efficient and selective synergistic photodynamic and photothermal therapy against hypoxic tumor cells. Chem Commun Epub ahead
Zou L, Wang H, He B et al (2016) Current approaches of photothermal therapy in treating cancer metastasis with nanotherapeutics. Theranostics 6:762–772. https://doi.org/10.7150/thno.14988
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 Springer Nature Singapore Pte Ltd.
About this entry
Cite this entry
Requena, M.B., Stringasci, M.D., Buzzá, H.H. (2023). Optical Techniques for Treatment and Tissue Evaluation Using Skin Models for Preclinical Studies. In: Pathak, S., Banerjee, A., Bisgin, A. (eds) Handbook of Animal Models and its Uses in Cancer Research. Springer, Singapore. https://doi.org/10.1007/978-981-19-3824-5_29
Download citation
DOI: https://doi.org/10.1007/978-981-19-3824-5_29
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-19-3823-8
Online ISBN: 978-981-19-3824-5
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences