Search
Search Results
-
The immunological and metabolic landscape in primary and metastatic liver cancer
The liver is the sixth most common site of primary cancer in humans, and generally arises in a background of cirrhosis and inflammation. Moreover,...
-
The emerging landscape of exosomal CircRNAs in solid cancers and hematological malignancies
Circular RNAs (circRNAs) are a type of recently discovered noncoding RNA. They exert their biological functions by competitively binding to microRNAs...
-
The Regulatory Landscape of New Health Technologies and Nanotechnologies: The Role of Complexity of Nanosystems
Herein we present the modern issue of new health technologies that emerge in Medicine and Therapeutics, with regard to their development, regulatory...
-
Virus Evolution on Fitness Landscapes
The landscape paradigm is revisited in the light of evolution in simple systems. A brief overview of different classes of fitness landscapes is...
-
The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability
BackgroundCancer evolution depends on epigenetic and genetic diversity. Historically, in multiple myeloma (MM), subclonal diversity and tumor...
-
Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells during JEV Infection
Japanese encephalitis virus (JEV) is a leading cause of viral encephalitis in endemic regions of Asia. The neurotropism of JEV and its...
-
Isatin derivatives as broad-spectrum antiviral agents: the current landscape
In recent decades, several viruses have resulted in large outbreaks with serious health, economic and social consequences. The current unprecedented...
-
Epigallocatechin gallate and curcumin inhibit Bcl-2: a pharmacophore and docking based approach against cancer
The protein Bcl-2, well-known for its anti-apoptotic properties, has been implicated in cancer pathogenesis. Identifying the primary gene responsible...
-
The evolving metabolic landscape of chromatin biology and epigenetics
Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These inputs — which include both nutrient availability as a...
-
m6A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma
BackgroundLung adenocarcinoma (LUAD) is a common type of lung cancer with a high risk of metastasis, but the exact molecular mechanisms of metastasis...
-
Metabolic Reprogramming As a Prostate Cancer Hallmark
Arising from a disruption of regular biological circuits and control mechanisms, cancer exhibits a remarkable inter- and intra-type heterogeneity, an...
-
Deciphering metabolic heterogeneity in retinoblastoma unravels the role of monocarboxylate transporter 1 in tumor progression
BackgroundTumors exhibit metabolic heterogeneity, influencing cancer progression. However, understanding metabolic diversity in retinoblastoma (RB),...
-
The ethics of artificial intelligence systems in healthcare and medicine: from a local to a global perspective, and back
Artificial intelligence systems (ai-systems) (e.g. machine learning, generative artificial intelligence), in healthcare and medicine, have been...
-
Label-Free Quantitative Proteomic Analysis of Three Strains of Viscerotropic Leishmania Isolated from Patients with Different Epidemiological Types of Visceral Leishmaniasis in China
BackgroundThere are three epidemiological types of visceral leishmaniasis in China, which are caused by Leishmania strains belonging to the L....
-
ctDNA and Lung Cancer
The discovery of cell-free DNA (cfDNA) in biofluids such as blood, saliva, urine, and pleural fluid has broadened our understanding of extracellular...
-
Insilico design of an allosteric modulator targeting the protein–protein interaction site of 3 Phosphoinositide dependent Kinase-1: design, synthesis and biological activity
The signalling pathways in human cells mostly rely on protein–protein interactions (PPI) for their function. Such a PPI site in 3 Phosphoinositide...
-
Dynamic Docking Using Multicanonical Molecular Dynamics: Simulating Complex Formation at the Atomistic Level
Multicanonical molecular dynamics (McMD)-based dynamic docking has been applied to predict the native binding configurations for several protein...
-
Characteristics of pre-metastatic niche: the landscape of molecular and cellular pathways
Metastasis is a major contributor to cancer-associated deaths. It involves complex interactions between primary tumorigenic sites and future...
-
In Silico Methods for Environmental Risk Assessment: Principles, Tiered Approaches, Applications, and Future Perspectives
This chapter aims to introduce the reader to the basic principles of environmental risk assessment of chemicals and highlights the usefulness of...
-
Mitochondrial heteroplasmic shifts reveal a positive selection of breast cancer
BackgroundBreast cancer is, despite screening, not always detected early enough and is together with other tumor types known to shed genetic...
