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Epilepsy and Oxidative Stress
Epilepsy is one of the most common neurological condition reported worldwide. Oxidative stress and neuroinflammation have been strongly associated...
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A Pilot Study of High-Definition Transcranial Direct Current Stimulation in Refractory Status Epilepticus: The SURESTEP Trial
Refractory status epilepticus (RSE) is a life-threatening emergency with high mortality and poor functional outcomes in survivors. Treatment is...
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Favorite colors of patients with drug-resistant epilepsy: pilot study
ObjectiveTo evaluate the favorite colors of patients with drug-resistant epilepsy.
MethodsFollowing examination, 50 patients were diagnosed in...
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Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions
Epilepsy is a disease which affects between 1 and 2% of the population, and a large proportion of these people do not react to currently available...
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The reference range of lamotrigine in the treatment of epilepsy in children: a systematic review
PurposeThis study intends to assess the reference range of lamotrigine concentration for treating childhood epilepsy.
MethodsPubMed, Ovid-Embase,...
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The Neuroprotective Effect Associated with Echinops spinosus in an Acute Seizure Model Induced by Pentylenetetrazole
Echinops spinosus (ES) is a medicinal plant with a wide range of pharmacological and biological effects. It is a medicinal herb having a variety of...
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Seizures Induce Hypoxia, and Hypoxia Induces Seizures: A Perverse Relationship That Increases the Risk of Sudden Unexpected Death in Epilepsy (SUDEP)
Hypoxia can promote both rescue-survival mechanisms and irreversible events leading to cell death. How many types of hypoxia are known, and what is...
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Protocol for 6 Hz Corneal Stimulation in Rodents for Refractory Seizures
The 6-hertz (6 Hz) model is an effective tool to screen drugs for psychomotor seizures and/or treatment-resistant focal seizures. It is known to...
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Models of Seizures and Epilepsy: Important Tools in the Discovery and Evaluation of Novel Epilepsy Therapies
Models of seizures and epilepsy continue to play an important role in the early discovery of new therapies for the symptomatic treatment of epilepsy....
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Alzheimer’s Disease and Epilepsy: A Perspective on the Opportunities for Overlap** Therapeutic Innovation
Early-onset Alzheimer’s disease (AD) is associated with variants in amyloid precursor protein (APP) and presenilin (PSEN) 1 and 2. It is increasingly...
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Long-term Effect of Multichannel tDCS Protocol in Patients with Central Cortex Epilepsies Associated with Epilepsia Partialis Continua
Epilepsia partialis continua (EPC) is a rare type of focal motor status epilepticus that causes continuous muscle jerking in a specific part of the...
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Seizure Rescue Therapies: Comparing Approved and Commonly Used Benzodiazepine Formulations
Acute seizure therapies given out of the hospital are important for interrupting acute repetitive and prolonged seizures and preventing...
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Anticonvulsant effect of pterostilbene and its influence on the anxiety- and depression-like behavior in the pentetrazol-kindled mice: behavioral, biochemical, and molecular studies
RationalePterostilbene is the 3,5-dimethoxy derivative of resveratrol with numerous beneficial effects including neuroprotective properties....
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End-stage ADPKD with a low-frequency PKD1 mosaic variant accelerated by chemoradiotherapy
Autosomal dominant polycystic kidney disease (ADPKD) is commonly caused by PKD1 , and mosaic PKD1 variants result in milder phenotypes. We present the...
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Transcranial brain parenchyma sonography in patients with juvenile myoclonic epilepsy
IntroductionThere are rising evidences that subcortical structures, including the basal ganglia, are affected in patients with epilepsy. These...
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Tiagabine and zonisamide differentially regulate the glial properties in an astrocyte-microglia co-culture model of inflammation
Due to the role of astrocytes and microglia in the pathophysiology of epilepsy and limited studies of antiseizure medication (ASM) effects on glial...
