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Prevalence and Impact of Fatigue in Children with Primary Immunodeficiency Disorders: a Quantitative Single-Center Study
Although fatigue is a common symptom in adult patients with primary immunodeficiencies (PID), data in pediatric patients are limited. The goal of...
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Single-Molecule FRET Analyses of NMDA Receptors
Single-molecule fluorescence resonance energy transfer (smFRET) enables the real-time observation of conformational changes in a single protein...
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Future of Drug Development in Space: Unmanned Satellites and Vehicles
The microgravity environment of space provides new opportunities for drug discovery and development. Until recently, the majority of studies in the...
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Localization of Deep Ischemia and Hemorrhage in Preterm Infants’ Head with Near-Infrared Optical Tomography: A Numerical Case Study
Background and aim: Preterm infants have a high incidence of brain lesions that may lead to long-term disabilities. Early diagnosis of cerebral...
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Probe Design Optimization for Time-Domain NIROT “Pioneer” System for Imaging the Oxygenation of the Preterm Brain
In preterm infants, there is a risk of life-lasting impairments due to hemorrhagic/ischemic lesions. Our time-domain (TD) near-infrared optical...
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In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage
The neonatal brain is a vulnerable organ, and lesions due to hemorrhage and/or ischemia occur frequently in preterm neonates. Even though...
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Molecular Mechanisms Encoding Strains of Prions and Prion-Like Misfolded Proteins
Yeast, fungal, and mammalian prions determine heritable as well as infectious traits (Shorter J, Lindquist S. Nat Rev Genet, 6:435–450, 2005; Wickner...
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Inborn Errors of Immunity on the Island of Ireland — a Cross-Jurisdictional UKPID/ESID Registry Report
The epidemiology of inborn errors of immunity (IEI) in the Republic of Ireland was first published in 2005 but has not been updated since. IEI...
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Brain alarm by self-extracellular nucleic acids: from neuroinflammation to neurodegeneration
Neurological disorders such as stroke, multiple sclerosis, as well as the neurodegenerative diseases Parkinson's or Alzheimer's disease are...
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Validation and Comparison of Monte Carlo and Finite Element Method in Forward Modeling for Near Infrared Optical Tomography
Near infrared optical tomography (NIROT) is a non-invasive imaging technique to provide physiological information e.g. the oxygenation of tissue. For...
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Effects of ZJ0273 on barley and growth recovery of herbicide-stressed seedlings through application of branched-chain amino acids
In this study, we evaluated the effect of the herbicide propyl 4-(2-(4,6-dimethoxypyrimidin-2-yloxy)benzylamino) benzoate (ZJ0273) on barley growth...
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Future of Drug Development in Space: Unmanned Satellites and Vehicles
The microgravity environment of space provides new opportunities for drug discovery and development. Until recently, the majority of studies in the...
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Clinical Symptoms, Laboratory Parameters and Long-Term Follow-up in a National DADA2 Cohort
Deficiency of adenosine deaminase-2 (DADA2) is an autosomal recessive autoinflammatory disease with an extremely variable disease presentation. This...
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Time-Resolved NIROT ‘Pioneer’ System for Imaging Oxygenation of the Preterm Brain: Preliminary Results
In preterm infants, there is a risk of long-term cognitive, motor and behavioral impairments due to hemorrhagic and/or ischemic lesions. If detected...
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Symptoms and yield loss caused by rice stripe mosaic virus
BackgroundRice stripe mosaic virus (RSMV) is a tentative new Cytorhabdovirus species in family Rhabdoviridae transmitted by the leafhopper Recilia...
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Phenotypic, Physiological and Biochemical Delineation of Wheat Genotypes Under Different Stress Conditions
Wheat is a vital crop, providing calories, nutrients and versatility in the food industry. However, the combination of heat and drought stress,...
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Remote Controlled Autonomous Microgravity Lab Platforms for Drug Research in Space
Research conducted in microgravity conditions has the potential to yield new therapeutics, as advances can be achieved in the absence of phenomena...
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Metagenomics insights into responses of rhizobacteria and their alleviation role in licorice allelopathy
BackgroundAllelopathy is closely associated with rhizosphere biological processes, and rhizosphere microbial communities are essential for plant...
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Identification of a major quantitative trait locus underlying salt tolerance in ‘Jidou 12’ soybean cultivar
BackgroundIdentification of the quantitative trait locus (QTL) underlying salt tolerance is a prerequisite for marker-assisted selection in the...
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Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer’s disease
BackgroundProteomic characterization of microglia provides the most proximate assessment of functionally relevant molecular mechanisms of...
