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In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage

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Oxygen Transport to Tissue XLII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1269))

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Abstract

The neonatal brain is a vulnerable organ, and lesions due to hemorrhage and/or ischemia occur frequently in preterm neonates. Even though neuroprotective therapies exist, there is no tool available to detect the ischemic lesions. To address this problem, we have recently designed and built the new time-domain near-infrared optical tomography (TD NIROT) system – Pioneer. Here we present the results of a phantom study of the system performance. We used silicone phantoms to mimic risky situations for brain lesions: hemorrhage and hypoxia. Employing Pioneer, we were able to reconstruct accurately both position and optical properties of these inhomogeneities.

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Acknowledgments

This research was supported by Swiss Cancer Research grant KFS-3732-08-2015, the Swiss National Science Foundation project 159490, the National Competence Center in Biomedical Imaging (NCCBI), and CONACyT by the CVU-627802. MW declares that he is founder and president of the board of OxyPrem AG.

Author information

Authors and Affiliations

  1. Biomedical Optics Research Laboratory (BORL), Department of Neonatology, University of Zurich and University Hospital Zurich, Zurich, Switzerland

    J. Jiang, S. Lindner, A. Di Costanzo-Mata, M. Wolf & A. Kalyanov

  2. Advanced Quantum Architecture (AQUA) laboratory, School of Engineering, EPFL Lausanne, Lausanne, Switzerland

    S. Lindner & E. Charbon

  3. Applied Quantum Architectures, Delft University of Technology, Delft, the Netherlands

    C. Zhang & E. Charbon

Authors
  1. J. Jiang
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  2. S. Lindner
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  3. A. Di Costanzo-Mata
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  4. C. Zhang
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  5. E. Charbon
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  6. M. Wolf
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  7. A. Kalyanov
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Corresponding author

Correspondence to A. Kalyanov .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, University of New Mexico, Albuquerque, NM, USA

    Edwin M. Nemoto

  2. Bozen, Italy

    Eileen M. Harrison

  3. Department of Chemistry, New Mexico Institute of Mining and Technology (New Mexico Tech), Socorro, NM, USA

    Sally C. Pias

  4. Lovelace Biomedical Research Institute, Albuquerque, NM, USA

    Denis E. Bragin

  5. St. Lorenzen, Italy

    David K. Harrison

  6. Department of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA

    Joseph C. LaManna

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Jiang, J. et al. (2021). In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage. In: Nemoto, E.M., Harrison, E.M., Pias, S.C., Bragin, D.E., Harrison, D.K., LaManna, J.C. (eds) Oxygen Transport to Tissue XLII. Advances in Experimental Medicine and Biology, vol 1269. Springer, Cham. https://doi.org/10.1007/978-3-030-48238-1_54

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