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1. Forensic Chemistry

   Forensic Chemistry applies the principles and techniques of chemical science to forensic analysis of evidences. This includes, but not limited to,...

   Vijay Kumar Yadav, Alok Kumar, ... Ankit Srivastava in Textbook of Forensic Science

   Chapter 2023
   

2. TNF–TNFR2 Signal Plays a Decisive Role in the Activation of CD4+Foxp3+ Regulatory T Cells: Implications in the Treatment of Autoimmune Diseases and Cancer

   The puzzling biphasic or dual roles of tumor necrosis factor α (TNF) in the inflammatory and immune responses are likely to be mediated by distinct...

   Md Sahidul Islam, Yang Yang, **n Chen in T Regulatory Cells in Human Health and Diseases

   Chapter 2021
   

3. Coordinated dysregulation of cancer progression by the HER family and p21-activated kinases

   Most epithelial cancer types are polygenic in nature and are driven by coordinated dysregulation of multiple regulatory pathways, genes, and protein...

   Rakesh Kumar, Aswathy Mary Paul, ... M. Radhakrishna Pillai in Cancer and Metastasis Reviews

   Article 21 August 2020
   

4. Autophagy and Tumour Chemotherapy

   Chemotherapy is an important means of treating malignant tumours. The main role of chemotherapy drugs is to induce cell death. However, the apoptotic...

   **aojuan Hou, **ghua Jiang, ... Lixin Wei in Autophagy: Biology and Diseases

   Chapter 2020
   

5. The role of the bacterial protease Prc in the uropathogenesis of extraintestinal pathogenic Escherichia coli

   Background

   Extraintestinal pathogenic E. coli (ExPEC) remains one of the most prevalent bacterial pathogens that cause extraintestinal infections,...

   Wen-Chun Huang, Chung-Yen Lin, ... Ching-Hao Teng in Journal of Biomedical Science

   Article Open access 03 January 2020
   

6. Aberrantly expressed Bruton’s tyrosine kinase preferentially drives metastatic and stem cell-like phenotypes in neuroblastoma cells

   Purpose

   Neuroblastoma, a common childhood tumor, remains one of the most elusive diseases to treat. To date, high-risk neuroblastoma is associated...

   Narpati Wesa Pikatan, Yen-Lin Liu, ... Chi-Tai Yeh in Cellular Oncology

   Article 23 July 2020
   

7. LINC00173.v1 promotes angiogenesis and progression of lung squamous cell carcinoma by sponging miR-511-5p to regulate VEGFA expression

   Background

   Anti-angiogenic therapy represents a promising strategy for non-small-cell lung cancer (NSCLC) but its application in lung squamous cell...

   Jiarong Chen, Aibin Liu, ... Yanming Huang in Molecular Cancer

   Article Open access 30 May 2020
   

8. Rufy

   Mayuko Ichimura, Atsuko Nakanishi, ... Satoru Matsuda in Encyclopedia of Signaling Molecules

   Reference work entry 2018
   

9. Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment

   Tumor-associated macrophages are an abundant cell type in the tumor microenvironment. These macrophages serve as a promising target for treatment of...

   Kayla V. Myers, Sarah R. Amend, Kenneth J. Pienta in Molecular Cancer

   Article Open access 14 May 2019
   

10. Loss of PDPK1 abrogates resistance to gemcitabine in label-retaining pancreatic cancer cells

    Background

    Label-retaining cancer cells (LRCC) have been proposed as a model of slowly cycling cancer stem cells (CSC) which mediate resistance to...

    Dandan Li, John E. Mullinax, ... Udo Rudloff in BMC Cancer

    Article Open access 31 July 2018
    

11. Cancer driver G-protein coupled receptor (GPCR) induced β-catenin nuclear localization: the transcriptional junction

    G protein-coupled receptors (GPCRs) comprise the main signal-transmitting components in the cell membrane. Over the past several years, biochemical...

    Jeetendra Kumar Nag, Tatyana Rudina, ... Rachel Bar-Shavit in Cancer and Metastasis Reviews

    Article 08 December 2017
    

12. Tumor Infiltrating Lymphocytes in Breast Cancer Patients with Progressive Disease during Neoadjuvant Chemotherapy

    A minority of breast cancer (BC) patients progress during neoadjuvant chemotherapy (NCT). The aim of this study was to assess the value of Tumor...

    Jacques Raphael, S. Nofech-Mozes, ... S. Gandhi in Pathology & Oncology Research

    Article 08 December 2017
    

13. Rufy

    Mayuko Ichimura, Atsuko Nakanishi, ... Satoru Matsuda in Encyclopedia of Signaling Molecules

    Living reference work entry 2017
    

14. Focal Adhesion Kinase (FAK)

    Haiqi Chen, C. Yan Cheng in Encyclopedia of Signaling Molecules

    Reference work entry 2018
    

15. BTK Inhibitors: Focus on Ibrutinib and Similar Agents

    Since Bruton tyrosine kinase (BTK) is a critical effector molecule for B cell development and lymphomagenesis, BTK inhibitors have been investigated...

    Mattias Mattsson, Lydia Scarfò in Resistance of Targeted Therapies Excluding Antibodies for Lymphomas

    Chapter 2018
    

16. Role of Non Receptor Tyrosine Kinases in Hematological Malignances and its Targeting by Natural Products

    Tyrosine kinases belong to a family of enzymes that mediate the movement of the phosphate group to tyrosine residues of target protein, thus...

    Kodappully S. Siveen, Kirti S. Prabhu, ... Shahab Uddin in Molecular Cancer

    Article Open access 19 February 2018
    

17. The expression and role of tyrosine kinase ETK/BMX in renal cell carcinoma

    Background

    Expression of the non-receptor tyrosine kinase ETK/BMX has been reported in several solid tumors, but the underlying molecular mechanisms...

    **tao Zhuang, **angan Tu, ... Shaopeng Qiu in Journal of Experimental & Clinical Cancer Research

    Article Open access 07 March 2014
    

18. Lipid Peroxidation-Dependent Cell Death Regulated by GPx4 and Ferroptosis

    Glutathione peroxidase 4 (Phospholipid hydroperoxide glutathione peroxidase, PHGPx) can directly reduce phospholipid hydroperoxide. Depletion of GPx4...

    Hirotaka Imai, Masaki Matsuoka, ... Tomoko Koumura in Apoptotic and Non-apoptotic Cell Death

    Chapter 2016
    

19. Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks

    Pim kinases are being implicated in oncogenic process in various human cancers. Pim kinases primarily deal with three broad categories of functions...

    Goodwin G. **esh, Sharada Mokkapati, ... Edwin E. Morales in Apoptosis

    Article 20 September 2016
    

20. PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression

    Triple-negative breast cancer (TNBC), in which cells lack expression of the estrogen receptor (ER), the progesterone receptor (PR) and the ERBB2...

    Dai Horiuchi, Roman Camarda, ... Andrei Goga in Nature Medicine

    Article 24 October 2016