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  1. Identification of purinergic system components in the venom of Bothrops mattogrossensis and the inhibitory effect of specioside extracted from Tabebuia aurea

    Snake bites are a severe problem in the countryside of Brazil and are usually attributed to snakes of the genera Bothrops, Crotalus , and Lachesis ....

    Dhébora Albuquerque Dias, Kamylla Fernanda Souza de Souza, ... Edgar Julian Paredes-Gamero in Purinergic Signalling
    Article 03 July 2024

  2. In-Vitro Study of the Binding of Atorvastatin with Adenine using Multi-Spectroscopic Approaches

    Atorvastatin—an oral lipid regulating drug is a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), which...

    Reem N. El Gammal, Heba Elmansi, ... Mohammed E. A. Hammouda in Journal of Fluorescence
    Article 03 July 2024

  3. Multi-scale modeling to investigate the effects of transcranial magnetic stimulation on morphologically-realistic neuron with depression

    Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique to activate or inhibit the activity of neurons, and thereby...

    Licong Li, Shuaiyang Zhang, ... **uling Liu in Cognitive Neurodynamics
    Article 03 July 2024

  4. Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer

    Mismatch repair (MMR)-deficient cancer evolves through the stepwise erosion of coding homopolymers in target genes. Curiously, the MMR genes MutS...

    Hamzeh Kayhanian, William Cross, ... Marnix Jansen in Nature Genetics
    Article Open access 03 July 2024

  5. Systematic Review on Flow Cytometry as a Versatile Tool for Disease Diagnosis

    Purpose of Review

    Quantification and identification of cell fate remain to be the most important step within research and diagnostic laboratories.With...

    Karunya Jenin Ravindranath, Hemalatha Srinivasan in Current Pharmacology Reports
    Article 03 July 2024

  7. OpenHands: An Open-Source Statistical Shape Model of the Finger Bones

    This paper presents statistical shape models of the four fingers of the hand, with an emphasis on anatomic analysis of the proximal and distal...

    T. A. Munyebvu, C. D. Metcalf, ... A. S. Dickinson in Annals of Biomedical Engineering
    Article Open access 03 July 2024

  8. Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease

    APOE4 is the strongest genetic risk factor for Alzheimer’s disease (AD), with increased odds ratios in female carriers. Targeting amyloid plaques...

    Neta Rosenzweig, Kilian L. Kleemann, ... Oleg Butovsky in Nature Medicine
    Article 03 July 2024

  9. Building genomic capacity for precision health in Africa

    The African continent is poised to have a pivotal role in the global population landscape, with the United Nations projecting a population of 2.5...

    Alhaji Olono, Vera Mitesser, ... Christian Happi in Nature Medicine
    Article 03 July 2024

  10. KLK7 expression in human tumors: a tissue microarray study on 13,447 tumors

    Background

    Kallikrein-related peptidase 7 (KLK7) is a chymotrypsin-like serine protease which is essential for the desquamation of corneocytes and...

    Simon Kind, Carolina Palacios Castillo, ... Frank Jacobsen in BMC Cancer
    Article Open access 03 July 2024

  11. Central nervous system-associated macrophages modulate the immune response following stroke in aged mice

    Age is a major nonmodifiable risk factor for ischemic stroke. Central nervous system-associated macrophages (CAMs) are resident immune cells located...

    Damien Levard, Célia Seillier, ... Marina Rubio in Nature Neuroscience
    Article 03 July 2024

  12. DKK1 loss promotes endometrial fibrosis via autophagy and exosome-mediated macrophage-to-myofibroblast transition

    Introduction

    Intrauterine adhesions (IUA) manifest as endometrial fibrosis, often causing infertility or recurrent miscarriage; however, their...

    Zhanqin Zhang, Jianguo Hu in Journal of Translational Medicine
    Article Open access 03 July 2024

  13. Carbohydrate antigen 125 on epicardial fat and its association with local inflammation and fibrosis-related markers

    Background

    Carbohydrate antigen 125 (CA125) is a proteolytic fragment of MUC-16 that is increased in heart failure (HF) and associated with...

    Sonia Eiras, Rafael de la Espriella, ... José R. González-Juanatey in Journal of Translational Medicine
    Article Open access 03 July 2024

  14. Tissue-resident memory T cells break tolerance to renal autoantigens and orchestrate immune-mediated nephritis

    Immune-mediated nephritis is a leading cause of acute kidney injury and chronic kidney disease. While the role of B cells and antibodies has been...

    Frederic Arnold, Laurence Kupferschmid, ... Yakup Tanriver in Cellular & Molecular Immunology
    Article Open access 03 July 2024

  17. Revisiting reactive oxygen species production in hypoxia

    Cellular responses to hypoxia are crucial in various physiological and pathophysiological contexts and have thus been extensively studied. This has...

    Ricardo Alva, Jacob E. Wiebe, Jeffrey A. Stuart in Pflügers Archiv - European Journal of Physiology
    Article 03 July 2024

  18. Biosynthesis, Structural, Spectroscopic, Photoluminescence, and Antifungal Activity of Ni-doped CeO2 Nanoparticles

    Pedalium Murex leaf extract was used in this study to create Nickel-doped Cerium oxide (Ni-CeO 2 ) nanoparticles at 3 mol% and 5 mol% molar...

    T. Lohitha, Helen Merina Albert in Journal of Fluorescence
    Article 03 July 2024

  19. Exploring the molecular binding mechanism of 6-fluoro, 4-hydroxy, 2- methyl quinoline with TiO2 nanoparticles: A spectroscopic, thermodynamic, and insights into the solvatochromic effect

    This study investigates the interaction between titanium oxide nanoparticles (TiO 2 NPs) and the heterocyclic fluorophore...

    Deepa H. Krishne, Kalpana Sharma, ... V. V. Koppal in Journal of Fluorescence
    Article 03 July 2024

  20. Investigation on the Influence of Solvents Environment on the Optoelectronic Properties of the Fluorescent Probe 1,3,4-Oxadiazole Analogues: A Combined Theoretical and Experimental Study

    This study investigates the photophysical properties of a nitrobenzene-substituted 1,3,4-oxadiazole derivative (OX-NO) using both theoretical and...

    A. K. Maniyar, Nadaf Y. F, ... M. V. Murugendrappa in Journal of Fluorescence
    Article 03 July 2024
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