Abstract
Pedalium Murex leaf extract was used in this study to create Nickel-doped Cerium oxide (Ni-CeO2) nanoparticles at 3 mol% and 5 mol% molar concentrations. The biosynthesized process was applied for the fabrication of Ni-CeO2 NPs. The X-ray diffraction method was used to identify their crystal structure. The XRD measurements showed that the Ni-CeO2 NPs crystallized into the face-centred cubic system. Fourier transform infrared spectral study was applied to explore the molecular vibrations and chemical bonding. The surface texture and chemical ingredients of Ni-CeO2 NPs were studied using field-emission scanning electron microscopy and energy-dispersive X-ray analysis. The EDX map** spectra illustrate the uniform dispersal of Ce, Ni, and O atoms over the sample’s surface. X-ray photoelectron spectroscopy (XPS) was conducted to confirm the chemical state of the Ni-CeO2 NPs. UV–Vis spectrum study was performed to ascertain the photon absorption, bandgap, and Urbach edge of Ni-CeO2 NPs. Photoluminescence (PL) research has been used to study the light-emitting characteristic of Ni-CeO2 NPs. The emissive intensity transition corresponding to Ni-CeO2 NPs was found to increase with the dopant level. The CIE 1931 chromaticity map was plotted to find the aptness of the samples for optical uses. The antifungal ability of Ni-CeO2 NPs was evaluated against the fungi candida albicans and candida krusein with the agar well-diffusion process. The fungicidal activity of the 3 mol% Ni doped CeO2 nanoparticles has shown a maximum zone of inhibition. The experimental findings illustrate the utility of Ni-CeO2 NPs for optical and antifungal applications.
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10895-024-03831-5/MediaObjects/10895_2024_3831_Fig1_HTML.png)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10895-024-03831-5/MediaObjects/10895_2024_3831_Fig2_HTML.png)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10895-024-03831-5/MediaObjects/10895_2024_3831_Fig3_HTML.png)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10895-024-03831-5/MediaObjects/10895_2024_3831_Fig4_HTML.png)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10895-024-03831-5/MediaObjects/10895_2024_3831_Fig5_HTML.png)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10895-024-03831-5/MediaObjects/10895_2024_3831_Fig6_HTML.png)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10895-024-03831-5/MediaObjects/10895_2024_3831_Fig7_HTML.png)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10895-024-03831-5/MediaObjects/10895_2024_3831_Fig8_HTML.png)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10895-024-03831-5/MediaObjects/10895_2024_3831_Fig9_HTML.png)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10895-024-03831-5/MediaObjects/10895_2024_3831_Fig10_HTML.png)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10895-024-03831-5/MediaObjects/10895_2024_3831_Fig11_HTML.png)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10895-024-03831-5/MediaObjects/10895_2024_3831_Fig12_HTML.png)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10895-024-03831-5/MediaObjects/10895_2024_3831_Fig13_HTML.png)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10895-024-03831-5/MediaObjects/10895_2024_3831_Fig14_HTML.png)
Data Availability
No datasets were generated or analysed during the current study.
References
Valentina M, Luisana DC, Stephen GJS, Simona O, Magda B, Anna C, Pierluigi R, Yuri V, Adriele M (2018) Silver nanoparticles as a medical device in healthcare settings: a five-step approach for candidate screening of coating agents. Roy Soc Open Sci 5:171113. https://doi.org/10.1098/rsos.171113
Ali F, Khalid NR, Nabi G, Ul-Hamid A, Ikram M (2021) Hydrothermal synthesis of cerium-doped Co3O4 nanoflakes as an electrode for supercapacitor application. Int J Ener Res 45:1999–2010. https://doi.org/10.1002/er.5893
Mohanraj K, Balasubramanian D, Chandrasekaran J, Chandra Bose A (2016) Synthesis and characterizations of Ag-doped CdO nanoparticles for P-N junction diode application. Mater Sci Semicond Process 79:74–91. https://doi.org/10.1016/j.mssp.2018.02.006
Kumar V, Sharma DK, Sharma KP, Agarwal S, Bansal MK, Dwivedi DH (2016) Structural, optical and electrical characterization of nanocrystalline CdO films for device applications. Optik 127:4254–4257. https://doi.org/10.1016/j.ijleo.2016.01.186
Rhoda JC, Chellammal S, Albert HM, Ravichandran K, AlosiousGonsago C (2024) Synthesis, Spectroscopic, and Antibacterial Characterizations of Cadmium-Based Nanoparticles. J Fluoresc 34:587–598. https://doi.org/10.1007/s10895-023-03290-4
Suchitra JP, Bharathi Devi V (2020) Synthesis and optical characterization of Cu(mq)2 nanoparticles. Inorg Nano-Metal Chem 51:756–760. https://doi.org/10.1080/24701556.2020.1800034
Kumar P, Kumar A, Rizvi MA, Moosvi SK, Krishnan V, Duvenhage MM, Roos WD, Swart HC (2020) Surface, optical and photocatalytic properties of Rb doped ZnO nanoparticles. Appl Surf Sci 514:145930. https://doi.org/10.1016/j.apsusc.2020.145930
Kumar P, Mathpal MC, Jagannath G, Prakash J, Maze JR, Roos WD, Swart HC (2021) Optical limiting applications of resonating plasmonic Au nanoparticles in a dielectric glass medium. Nanotechnol 32:345709. https://doi.org/10.1088/1361-6528/abfee6
Albert HM, Lohitha T, Alagesan K, AlosiousGonsago C, Vinita V (2021) Performance of ZnSO4 doped CeO2 nanoparticles and their antibacterial mechanism. Mater Tod Proceed 47:1030–1034. https://doi.org/10.1016/j.matpr.2021.06.124
Srinivasan MP, Uthiram C, Ayeshamariam A, Kaviyarasu K, Punithavelan N (2023) Dielectric performance of CeO2/ZnO core-shell nanocomposite with their structural, optical and morphological properties. J King Saud Univ Sci 35:102508. https://doi.org/10.1016/j.jksus.2022.102508
Dharmaraj VR, Chung RJ, Arularasu M, Rajendran TV, Kaviyarasu K (2023) Solid composite electrolyte formed via CeO2 nanoparticles and supramolecular network material for lithium-ion batteries. J Aus Ceram Soc 59:837–847. https://doi.org/10.1007/s41779-023-00877-9
Kaviyarasu K, Fuku X, Mola GT, Manikandan E, Kennedy J, Maaza M (2016) Photoluminescence of well-aligned ZnO doped CeO2 nanoplatelets by a solvothermal route. Mater Lett 183:351–354. https://doi.org/10.1016/j.matlet.2016.07.143
Kaviyarasu K, Manikandan E, Nuru ZY, Maaza M (2015) Investigation on the structural properties of CeO2 nanofibers via CTAB surfactant. Mater Lett 160:61–63. https://doi.org/10.1016/j.matlet.2015.07.099
Jayakumar G, Albert Irudayaraj A, Dhayal Raj A, John Sundaram S, Kaviyarasu K (2022) Electrical and magnetic properties of nanostructured Ni doped CeO2 for optoelectronic applications. J Phys Chem Soli 160:110369. https://doi.org/10.1016/j.jpcs.2021.110369
Kafader JO, Topolski JE, Jarrold CC (2016) Molecular and electronic structures of cerium and cerium suboxide clusters. J Chem Phys 145:154306. https://doi.org/10.1063/1.4964817
Kazemi S, Hosseingholian A, Gohari SD, Feirahi F, Moammeri F, Mesbahian G, Moghaddam ZS, Ren Q (2023) Recent advances in green synthesized nanoparticles: from production to application. Mater Today Sust 24:100500. https://doi.org/10.1016/j.mtsust.2023.100500
Nag S, Mitra O, Sankarganesh P, Bhattacharjee A, Mohanto S, Jaswanth Gowda BH, Kar S, Ramaiah S, Anbarasu A, Ahmed MG (2024) Exploring the emerging trends in the synthesis and theranostic paradigms of cerium oxide nanoparticles (CeONPs): A comprehensive review. Mater Tod Chem 35:101894. https://doi.org/10.1016/j.mtchem.2023.101894
Thakur N, Manna P, Das J (2019) Synthesis and biomedical applications of nanoceria, a redox-active nanoparticle. J Nanobiotechnol 17:84. https://doi.org/10.1186/s12951-019-0516-9
Jeevanandam J, Kiew SF, Boakye-Ansah S, Lau SY, Barhoum A, Danquah MK, Rodrigues J (2022) Green approaches for the synthesis of metal and metal oxide nanoparticles using microbial and plant extracts. Nanoscale 14:2534–2571. https://doi.org/10.1039/D1NR08144F
Sinha SN, Paul D (2015) Phytosynthesis of Silver Nanoparticles Using Andrographis paniculata Leaf Extract and Evaluation of Their Antibacterial Activities. Spect Lett 48:600–604. https://doi.org/10.1080/00387010.2014.938756
Ying S, Guan Z, Ofoegbu PC, Clubb P, Rico C, He F, Hong J (2022) Green synthesis of nanoparticles: Current developments and limitations. Environ Technol Innov 26:102336. https://doi.org/10.1016/j.eti.2022.102336
Ye L, Cao Z, Liu X, Cui Z, Li Z, Liang Y, Zhu S, Wu S (2022) Noble metal-based nanomaterials as antibacterial agents. J Alloy Compd 904:164091. https://doi.org/10.1016/j.jallcom.2022.164091
Rani N, Singh P, Kumar S, Kumar P, Bhankar V, Kumar K (2023) Plant-mediated synthesis of nanoparticles and their applications: A review. Mater Res Bull 163:112233. https://doi.org/10.1016/j.materresbull.2023.112233
Altaf M, Manoharadas S, Zeyad MT (2021) Green synthesis of cerium oxide nanoparticles using Acorus calamus extract and their antibiofilm activity against bacterial pathogens. Microscopy Res Tech 84:1638–1648. https://doi.org/10.1002/jemt.23724
Parvathy S, Manjula G, Balachandar R, Subbaiya R (2022) Green synthesis and characterization of cerium oxide nanoparticles from Artabotrys hexapetalus leaf extract and its antibacterial and anticancer properties. Mater Lett 314:131811. https://doi.org/10.1016/j.matlet.2022.131811
Joshi NC, Negi T, Gururani P (2023) Papaya (Carica papaya) leaves extract-based synthesis, characterizations and antimicrobial activities of CeO2 nanoparticles (CeO2 NPs). Inorg Nano-Metal Chem 1–8. https://doi.org/10.1080/24701556.2023.2166068
Sathiyapriya R, Balaji M, Rajesh S (2020) Bio-Synthesis of Cerium Oxide Nanoparticles from Coriandrum sativum L. Leaf Extract and their Antibacterial Activity. Int J Adv Sci Eng 6:1439–1444
Yulizar Y, Kusrini E, Apriandanu DOB, Nurdini N (2020) Datura metel L. Leaves extract mediated CeO2 nanoparticles: Synthesis, characterizations, and degradation activity of DPPH radical. Surf Interf 19:100437. https://doi.org/10.1016/j.surfin.2020.100437
Arumugam A, Karthikeyan C, Hameed ASH, Gopinath K, Gowri S, Karthika V (2015) Synthesis of cerium oxide nanoparticles using Gloriosa superba L. leaf extract and their structural, optical and antibacterial properties. Mater Sci Eng C 49:408–415. https://doi.org/10.1016/j.msec.2015.01.042
Maensiri S, Labuayai S, Laokul P, Klinkaewnarong J, Swatsitang E (2014) Structure and optical properties of CeO2 nanoparticles prepared by using lemongrass plant extract solution. Jpn J Appl Phys 53:06JG14. https://doi.org/10.7567/JJAP.53.06JG14
Bakkiyaraj R, Subramanian R, Balakrishnan M, Ravichandran K (2021) Biofabrication of CeO2 nanoparticles, characterization, photocatalytic, and biological activities. Inorg Nano-Metal Chem. 1–9. https://doi.org/10.1080/24701556.2021.1983841
Maqbool Q, Nazar M, Naz S, Hussain T, Jabeen N, Kausar R (2016) Antimicrobial potential of green synthesized CeO2 nanoparticles from Olea europaea leaf extract. Inter J Nanomed 11:5015–5025. https://www.tandfonline.com/doi/abs/10.2147/IJN.S113508
Aseyd Nezhad S, Es-haghi A, Tabrizi MH (2020) Green synthesis of cerium oxide nanoparticle using Origanum majorana L. leaf extract, its characterization, and biological activities. Appl Organometallic Chem 34:e5314. https://doi.org/10.1002/aoc.5314
Naidi SN, Harunsani MH, Tan AL, Mansoob Khan M (2022) Structural, Morphological and Optical Studies of CeO2 Nanoparticles Synthesized Using Aqueous Leaf Extract of Pometia pinnata. BioNanoSci 12:393–404. https://doi.org/10.1007/s12668-022-00956-4
Miri A, Sarani M (2018) Biosynthesis, characterization and cytotoxic activity of CeO2 nanoparticles. Ceram Internat 44:12642–12647. https://doi.org/10.1016/j.ceramint.2018.04.063
Sabouri Z, Sabouri M, Amiri MS, Khatami M, Darroudi M (2022) Plant-based synthesis of cerium oxide nanoparticles using Rheum turkestanicum extract and evaluation of their cytotoxicity and photocatalytic properties. Mater Technol 37:555–568. https://doi.org/10.1080/10667857.2020.1863573
Narayanan M, Kiran A, Natarajan D, Kandasamy S, Shanmugam S, Alshiekheid M, Almoallim HS, Pugazhendhi A (2022) The pharmaceutical potential of crude ethanol leaf extract of Pedalium murex (L.). Process Biochem 112:234–240. https://doi.org/10.1016/j.procbio.2021.12.003
Madasamy S, Ramananthatheerthan A, Marikani K, Venugopal D, Aldhayan SHA, Al-Dayan N, Palanivelu S, Dhanasekaran S (2023) Biofabrication of nickel oxide nanoparticles from Pedalium Murex leaf extract: A promising approach for biomedical and environmental applications. Surf Interf 40:103087. https://doi.org/10.1016/j.surfin.2023.103087
Suchitra JP, Kala A, Sagadevan S, Bharathi Devi V, Podder J (2019) Synthesis and characterization of bis(2 methyl-8-hydroxyquinoline) zinc nanoparticles for organic light emitting diode applications. Mol Simul 45:790–796. https://doi.org/10.1080/08927022.2019.1594418
Lohitha T, Albert HM (2023) Biosynthesis of pure and MnSO4 (II) doped CeO2 nanoparticles: Electrochemical studies and its antibacterial activity. Mater Tod Proceed. https://doi.org/10.1016/j.matpr.2023.02.239
Leel NS, Kiran M, Kumawat MK, Alvi PA, Vats VS, Patidar D, Dalela B, Kumar S, Dalela S (2023) Oxygen vacancy driven luminescence, ferromagnetic and electronic structure properties of Eu doped CeO2 nanoparticles. J Luminesc 263:119981. https://doi.org/10.1016/j.jlumin.2023.119981
Tiernan H, Byrne B, Sergei GK (2020) ATR-FTIR spectroscopy and spectroscopic imaging for the analysis of biopharmaceuticals. Spectrochim Acta A. 241:118636. https://doi.org/10.1016/j.saa.2020.118636
HM Albert, Gonsago CA (2023) Green Procedure for the Synthesis of Copper Nanoparticles using Nerium oleander Leaf Extract: Characterizations and Applications. Orient J Chem 39:792–797. https://doi.org/10.13005/ojc/390332
Geetha GV, Keerthana SP, Madhuri K, Sivakumar R (2021) Effect of solvent volume on the properties of ZnWO4 nanoparticles and their photocatalytic activity for the degradation of cationic dye. Inorg Chem Commun 132:108810. https://doi.org/10.1016/j.inoche.2021.108810
Lewczuk B, Szyryńska N (2021) Field-Emission Scanning Electron Microscope as a Tool for Large-Area and Large-Volume Ultrastructural Studies. Animals 11:3390. https://doi.org/10.3390/ani11123390
Abd Mutalib M, Rahman MA, Othman MHD, Ismail AF, Jaafar F (2017) Ch 9 - Scanning Electron Microscopy (SEM) and Energy-Dispersive X-Ray (EDX) Spectroscopy. In: Hilal N, Ismail AF, Matsuura T, Oatley-Radcliffe D (eds) Membrane Characterization. Elsevier, pp 161–179. https://doi.org/10.1016/B978-0-444-63776-5.00009-7
Jagadeesh P, Rangappa SM, Siengchin S (2024) Advanced characterization techniques for nanostructured materials in biomedical applications. Adva Ind Eng Poly Res 7:122–143. https://doi.org/10.1016/j.aiepr.2023.03.002
Parveen IM, Asvini V, Saravanan G, Ravichandran K (2017) Investigation of Ni-doped CeO2 nanoparticles–spintronics application. Ionics 23:1285–1291. https://doi.org/10.1007/s11581-016-1937-1
Deng D, Chen N, **ao X, Du S, Wang Y (2017) Electrochemical performance of CeO2 nanoparticle-decorated graphene oxide as an electrode material for supercapacitor. Ionics 23:121–129. https://doi.org/10.1007/s11581-016-1812-0
Albert HM, Saarwin SS, AlosiousGonsago C (2023) Growth, structural, optical, and thermal characterizations of l-serine-doped succinic acid (LSSA) crystals for nonlinear optical applications. J Mater Sci Mater Electron 34:1407. https://doi.org/10.1007/s10854-023-10840-w
Albert HM, AlosiousGonsago C (2023) Crystallization, vibrational, optical, dielectric, and hardness analyses of l-histidine hydrochloride hydrate crystals for nonlinear optical uses. J Nonlinear Opt Phys Mater. https://doi.org/10.1142/S0218863523500881
Kumar A, Kumar R, Verma N, Anupama AV, Choudhary HK, Philip R, Sahoo B (2020) Effect of the band gap and the defect states present within band gap on the non-linear optical absorption behavior of yttrium aluminium iron garnets. Opt Mater 108:110163. https://doi.org/10.1016/j.optmat.2020.110163
Ebrahimi S, Yarmand B (2020) Optimized optical band gap energy and Urbach tail of Cr2S3 thin films by Sn incorporation for optoelectronic applications. Physica B Conden Mat 593:412292. https://doi.org/10.1016/j.physb.2020.412292
Norouzzadeh P, Mabhouti Kh, Golzan MM, Naderali R (2020) Investigation of structural, morphological and optical characteristics of Mn substituted Al-doped ZnO NPs: A Urbach energy and Kramers-Kronig study. Optik 204:164227. https://doi.org/10.1016/j.ijleo.2020.164227
Albert HM, Jemima T, AlosiousGonsago C (2023) Synthesis, Spectroscopic, Optical, and Thermal Characterizations of Zinc (Tris)-Thiourea Sulfate: A Metal-Organic Crystal. J Fluoresc 34:1057–1063. https://doi.org/10.1007/S10895-023-03335-8
Huang T-H, Tian-Cheng Wu, Zhao F-Z, Zheng D, Luo C, Liang G-M, Zhao B (2021) Structures, electronic and luminescent properties of Cu(I)-quinoline complex at different temperatures and its application to a red light-emitting diode. Inorgan Chimi Acta 514:120008. https://doi.org/10.1016/j.ica.2020.120008
Bazhukova IN, Sokovnin SY, Ilves VG, Myshkina AV, Vazirov RA, Pizurova N, Kasyanova VV (2019) Luminescence and optical properties of cerium oxide nanoparticles. Opt Mater 92:136–142. https://doi.org/10.1016/j.optmat.2019.04.021
Kumar S, Choudhary RB (2023) Ameliorated optical, luminescent, and thermo-chemical features of polymer derived PPy-SnO2 nanocomposite as efficient emissive layer material (EML). Spectrochim Acta A 302:123099. https://doi.org/10.1016/j.saa.2023.123099
Livengood SJ, Drew RH, Perfect JR (2020) Combination Therapy for Invasive Fungal Infections. Curr Fungal Infect Rep 14:40–49. https://doi.org/10.1007/s12281-020-00369-4
Kumar P, Mathpal MC, Prakash J, Bennie CV, Roos WD, Swart HC (2020) Band gap tailoring of cauliflower-shaped CuO nanostructures by Zn do** for antibacterial applications. J Alloy Compd 832:154968. https://doi.org/10.1016/j.jallcom.2020.154968
Kumar P, Inwati GK, Mathpal MC, Ghosh S, Roos WD, Swart HC (2021) Defects induced enhancement of antifungal activities of Zn doped CuO nanostructures. Appl Surf Sci 560:150026. https://doi.org/10.1016/j.apsusc.2021.150026
Kumar P, Mathpal MC, Inwati GK, Ghosh S, Kumar V, Roos WD, Swart HC (2020) Optical and surface properties of Zn doped CdO nanorods and antimicrobial applications. Coll Surf A: Physicochem Eng Asp 605:125369. https://doi.org/10.1016/j.colsurfa.2020.125369
Kumar P, Mathpal MC, Ghosh S, Inwati GK, Maze JR, Duvenhage MM, Roos WD, Swart HC (2022) Plasmonic Au nanoparticles embedded in glass: Study of TOF-SIMS, XPS and its enhanced antimicrobial activities. J Alloy Compd 909:164789. https://doi.org/10.1016/j.jallcom.2022.164789
Achilonu CC, Kumar P, Swart HC, Roos WD, Maris GJ (2024) Zinc Oxide: Gold Nanoparticles (ZnO: Au NPs) Exhibited Antifungal Efficacy Against Aspergillus niger and Aspergillus candidus. BioNanoSci. https://doi.org/10.1007/s12668-024-01406-z
Juan CA, Pérez JM, de la Lastra FJ, Plou E-L (2021) The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies. Int J Mol Sci 22:4642. https://doi.org/10.3390/ijms22094642
Pryshchepa O, Pomastowski P, Buszewski B (2020) Silver nanoparticles: Synthesis, investigation techniques, and properties. Adva Coll Interf Sci 284:102246. https://doi.org/10.1016/j.cis.2020.102246
Funding
Not applicable.
Author information
Authors and Affiliations
Contributions
All authors, T. Lohitha and Helen Merina Albert contributed to the study conception and design. Material preparation, data collection, and analysis were performed by T. Lohitha. The first draft of the manuscript was written by T. Lohitha and Helen Merina Albert. The figures were prepared by T. Lohitha and Helen Merina Albert. All authors T. Lohitha and Helen Merina Albert commented on previous versions of the manuscript and all authors read and approved the final manuscript. All authors reviewed the manuscript.
Corresponding author
Ethics declarations
Compliance with Ethical standards
This article does not contain any studies with human participants or animals performed by any of the authors.
Competing Interests
The authors declare no competing interests.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Lohitha, T., Albert, H.M. Biosynthesis, Structural, Spectroscopic, Photoluminescence, and Antifungal Activity of Ni-doped CeO2 Nanoparticles. J Fluoresc (2024). https://doi.org/10.1007/s10895-024-03831-5
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s10895-024-03831-5