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Article
Open AccessHypoxia inducible factor-1α regulates microglial innate immune memory and the pathology of Parkinson’s disease
Neuroinflammation is one of the core pathological features of Parkinson’s disease (PD). Innate immune cells play a crucial role in the progression of PD. Microglia, the major innate immune cells in the brain, ...
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Chapter and Conference Paper
An Improved Canonical Correlation Analysis for EEG Inter-Band Correlation Extraction
As the most active and promising research fields of affective computing, emotion recognition based on EEG signal has attracted much attention. Traditional methods usually pay their attention on single-channel ...
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Chapter and Conference Paper
Research on Cross-Domain Text2SQL Enhancing Database Schema Awareness
Text2SQL has become an important research direction of natural language processing because of its abundant practical scenarios and research value. RAT-SQL is a Text2SQL method based on relational self-attentio...
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Chapter and Conference Paper
Research on Digital Maturity Evaluation Model of Public Hospitals
Building an evaluation model of digital maturity in public hospitals, combining the data management maturity model with the digital maturity model, evaluating the research progress of digital transformation in...
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Article
Open AccessNOD-like receptor NLRC5 promotes neuroinflammation and inhibits neuronal survival in Parkinson’s disease models
Parkinson’s disease (PD) is mainly characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and neuroinflammation mediated by overactivated microglia a...
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Article
Open AccessNon-cancer-related pathogenic germline variants and expression consequences in ten-thousand cancer genomes
DNA sequencing is increasingly incorporated into the routine care of cancer patients, many of whom also carry inherited, moderate/high-penetrance variants associated with other diseases. Yet, the prevalence an...
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Article
Map** QTL for seedling morphological and physiological traits under normal and salt treatments in a RIL wheat population
The genetic basis of 27 seedling traits under normal and salt treatments was fully analyzed in a RIL wheat population, and seven QTL intervals were validated in two other genetic populations.
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Chapter
Methods for Identification of Protein-RNA Interaction
The importance of RNA-protein interactions in regulation of mRNA and non-coding RNA function is increasingly appreciated. With the development of next generation high-throughput sequencing technologies, a vari...
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Article
Open AccessDownregulation of blood serum microRNA 29 family in patients with Parkinson’s disease
There is currently no reliable and easily applicable diagnostic marker for Parkinson’s disease (PD). The aims of the present study were to compare the expression profiles of the microRNA29 family (miR-29s) in ...
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Article
Fascin 1 promoted the growth and migration of non-small cell lung cancer cells by activating YAP/TEAD signaling
Fascin 1 (Fascin actin-bundling protein 1) is an actin-binding protein. Although several studies have reported the dysregulation of Fascin 1 in non-small cell lung cancer (NSCLC), its functions in the progress...
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Article
Open AccessConstruction and analysis of dynamic transcription factor regulatory networks in the progression of glioma
The combinatorial cross-regulation of transcription factors (TFs) plays an important role in cellular identity and function; however, the dynamic regulation of TFs during glioma progression remains largely unk...
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Article
Open AccessTiagabine Protects Dopaminergic Neurons against Neurotoxins by Inhibiting Microglial Activation
Microglial activation and inflammation are associated with progressive neuronal apoptosis in neurodegenerative disorders such as Parkinson’s disease (PD). γ-Aminobutyric acid (GABA), the major inhibitory neuro...
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Article
Open AccessPD_NGSAtlas: a reference database combining next-generation sequencing epigenomic and transcriptomic data for psychiatric disorders
Psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BP) are projected to lead the global disease burden within the next decade. Several lines of evidence suggest that epigenetic- or genetic-...
