-
Article
APTT critical value establishment in four different reagent/instrument systems based on single factor deficiencies
There are significant differences in the activated partial thromboplastin time (APTT) critical values reported in different studies, most of which does not make recommendations for any specific clear detection...
-
Article
Ferritin-mediated mitochondrial iron homeostasis is essential for the survival of hematopoietic stem cells and leukemic stem cells
Iron metabolism plays a crucial role in cell viability, but its relationship with adult stem cells and cancer stem cells is not fully understood. The ferritin complex, responsible for intracellular iron storag...
-
Article
Biomarkers of aging
Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...
-
Article
Ioversol Induced Microglia Proinflammatory Activation and Oxidative Stress in Rats
Contrast-induced encephalopathy (CIE) following angiography, though not often and reversible, can in some cases lead to permanent neurological dysfunction. To identify how neuroinflammation is involved in CIE,...
-
Article
Open AccessEVA1A regulates hematopoietic stem cell regeneration via ER-mitochondria mediated apoptosis
Excessive protein synthesis upon enhanced cell proliferation frequently results in an increase of unfolded or misfolded proteins. During hematopoietic regeneration, to replenish the hematopoietic system, hemat...
-
Protocol
Assessment of Ferroptosis in Hematopoietic Stem and Progenitor Cells
Hematopoietic stem cells (HSCs) are critical for maintaining hematopoiesis throughout life by utilizing their self-renewing and multipotent capabilities. Ferroptosis is a type of cell death characterized by th...
-
Chapter
Aging, Causes, and Rejuvenation of Hematopoietic Stem Cells
Hematopoietic stem cells (HSCs) undergo an age-related functional decline, which leads to a disruption of the blood system and contributes to the development of aging-associated hematopoietic diseases and mali...
-
Article
Fluorescent aptamer-modified mesoporous silica nanoparticles for quantitative acetamiprid detection
Acetamiprid (ACE) is widely used to control aphids, brown planthoppers, and other pests in agricultural production. However, ACE is difficult to degrade in the environment, resulting in excessive residue, whic...
-
Article
Open AccessDirect conversion of human umbilical cord mesenchymal stem cells into retinal pigment epithelial cells for treatment of retinal degeneration
Age-related macular degeneration (AMD) is a major vision-threatening disease. Although mesenchymal stem cells (MSCs) exhibit beneficial neural protective effects, their limited differentiation capacity in vivo...
-
Article
Process Optimization for the Preparation of Beta-cyhalothrin Microspheres by Using the Response Surface Methodology
Microcapsulses can effectively encapsulate, protect, and control the release of insecticides. In this study, emulsion–solvent evaporation method was used to fabricate microcapsules (MCs) by using beta-cyhaloth...
-
Article
Overexpression of pEGF improved the gut protective function of Clostridium butyricum partly through STAT3 signal pathway
Clostridium butyricum (C. butyricum) is a probiotic that could promote animal growth and protect gut health. So far, current studies mainly keep up with the basic biological functions of C. butyricum, missing the...
-
Article
Open AccessInflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention
Remarkable progress in ageing research has been achieved over the past decades. General perceptions and experimental evidence pinpoint that the decline of physical function often initiates by cell senescence a...
-
Article
Open AccessThe roles and mechanisms of hypoxia in liver fibrosis
Liver fibrosis occurs in response to any etiology of chronic liver injury. Lack of appropriate clinical intervention will lead to liver cirrhosis or hepatocellular carcinoma (HCC), seriously affecting the qual...
-
Article
Analysis of characteristics and mechanism of flow unsteadiness in a transonic compressor
This paper reveals the flow mechanism of unsteady flow oscillations at small mass flow rate conditions in a transonic compressor rotor. A series of unsteady RANS simulations were performed to achieve time-accu...
-
Article
Open AccessAntagonistic effects of IL-17 and Astragaloside IV on cortical neurogenesis and cognitive behavior after stroke in adult mice through Akt/GSK-3β pathway
We aimed to investigate the exact effect of IL-17 on regulating neural stem cells (NSCs) stemness and adult neurogenesis in ischemic cortex after stroke, how Astragaloside IV(As-IV) regulated IL-17 expression ...
-
Article
Open AccessElevated Hedgehog activity contributes to attenuated DNA damage responses in aged hematopoietic cells
Accumulation of DNA damage and myeloid-skewed differentiation characterize aging of the hematopoietic system, yet underlying mechanisms remain incompletely understood. Here, we show that aging hematopoietic pr...
-
Article
Open AccessHigh Canonical Wnt/β-Catenin Activity Sensitizes Murine Hematopoietic Stem and Progenitor Cells to DNA Damage
Aging is characterized by the accumulation of DNA damage and a decrease in stem cell functionality, yet molecular mechanisms that limit the maintenance of stem cells in response to DNA damage remain to be deli...
-
Chapter and Conference Paper
The Application of Intelligent Breaking and Feeding Technology for Aluminium Reduction Pot
Reducing voltage to achieve lower energy consumption has been a constant goal for operators. However, voltage reduction could be accompanied with and , having many disadvantages. In this paper, three di...
-
Article
Open AccessSelective conversion of CO2 and H2 into aromatics
Transformation of greenhouse gas CO2 and renewable H2 into fuels and commodity chemicals is recognized as a promising route to store fluctuating renewable energy. Although several C1 chemicals, olefins, and gasol...
-
Chapter and Conference Paper
Effects of Foundation Pit Width on the Anti-overturn Stability of Its Support Structure Under Ground Load
In this study, the anti-overturn stability of excavation support structure is firstly analyzed based on Rankine’s earth pressure theory and the static equilibrium method. Then the row piles plus inner support ...
