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Chapter
P450—mediated Insecticide Detoxification and Its Implication in Insecticide Efficacy
Insecticides have been extensively used to control insect pests that transmit human diseases and damage our crops by feeding or indirectly by transmitting plant diseases. However, insect pests still pose serio...
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Article
Enhanced Toxicity and Induction of Cytochrome P450s Suggest a Cost of “Eavesdrop**” in a Multitrophic Interaction
The inducibility of cytochrome P450 monooxygenases (P450s) and other xenobiotic-metabolizing enzymes is thought to reflect material and energy costs of biosynthesis. Efforts to detect such costs of detoxificat...
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Article
Ecological Significance of Induction of Broad-Substrate Cytochrome P450s by Natural and Synthetic Inducers in Helicoverpa zea
The polyphagous corn earworm Helicoverpa zea relies on cytochrome P450 monooxygenases with broad substrate specificities to cope with the wide diversity of phytochemicals it encounters among its numerous host pla...
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Article
Allelochemical Induction of Cytochrome P450 Monooxygenases and Amelioration of Xenobiotic Toxicity in Helicoverpa zea
Polyphagous herbivores encounter allelochemicals as complex mixtures in their host plants, and the toxicity of an individual compound may be influenced by the chemical matrix in which it is encountered. Certai...
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Article
Toxicity of Aflatoxin B1 to Helicoverpa zea and Bioactivation by Cytochrome P450 Monooxygenases
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Article
Toxicity of Aflatoxin B1 to Helicoverpa zea and Bioactivation by Cytochrome P450 Monooxygenases
Infestation of corn (Zea mays) by corn earworm (Helicoverpa zea) predisposes the plant to infection by Aspergillus fungi and concomitant contamination with the carcinogenic mycotoxin aflatoxin B1 (AFB1). Although...
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Article
Inhibition of CYP6B1-Mediated Detoxification of Xanthotoxin by Plant Allelochemicals in the Black Swallowtail (Papilio polyxenes)
The structural and biosynthetic diversity of allelochemicals in plants is thought to arise from selection for additive toxicity as a consequence of toxin mixture or for enhanced toxicity as a result of synergi...