TGF-Beta Signaling
Methods and Protocols
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Article
Open AccessSBML-SAT: a systems biology markup language (SBML) based sensitivity analysis tool
It has long been recognized that sensitivity analysis plays a key role in modeling and analyzing cellular and biochemical processes. Systems biology markup language (SBML) has become a well-known platform for ...
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Protocol
A Tutorial on Mathematical Modeling of Biological Signaling Pathways
Mathematical models have been widely used in the studies of biological signaling pathways. Among these studies, two systems biology approaches have been applied: top-down and bottom-up systems biology. The for...
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Measuring TGF-β Ligand Dynamics in Culture Medium
TGF-β plays an important role in a myriad of cell activities including differentiation, proliferation, and growth arrest. These effects are influenced by the concentration of TGF-β in the surrounding milieu, w...
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Open AccessCell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrest
Cancer is a life-threatening disease that affects one in three people. Although most cases are sporadic, cancer risk can be increased by genetic factors. It remains unknown why certain genes predispose for spe...
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Protocol
Absolute Quantification of TGF-β Signaling Proteins Using Quantitative Western Blot
Cell signaling governs the basic functions of cells by molecular interactions that involve of many proteins. The abundance of signaling proteins can directly influence cellular responses to external signal, co...
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Optogenetic Control of TGF-β Signaling
Cells employ signaling pathways to make decisions in response to changes in their immediate environment. The Transforming Growth Factor β (TGF-β) signaling pathway plays pivotal roles in regulating many cellul...
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Article
PhyloVelo enhances transcriptomic velocity field map** using monotonically expressed genes
Single-cell RNA sequencing (scRNA-seq) is a powerful approach for studying cellular differentiation, but accurately tracking cell fate transitions can be challenging, especially in disease conditions. Here we ...
