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Article
Open AccessA three-colour stress biosensor reveals multimodal response in single cells and spatiotemporal dynamics of biofilms
The plethora of stress factors that can damage microbial cells has evolved sophisticated stress response mechanisms. While existing bioreporters can monitor individual responses, sensors for detecting multimod...
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Article
Open AccessSingle-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states
Single-cell genomics technology has transformed our understanding of complex cellular systems. However, excessive cost and a lack of strategies for the purification of newly identified cell types impede their ...
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Article
Open AccessCell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrest
Cancer is a life-threatening disease that affects one in three people. Although most cases are sporadic, cancer risk can be increased by genetic factors. It remains unknown why certain genes predispose for spe...
