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Article
Open AccessPopulation structure and selection signal analysis of indigenous sheep from the southern edge of the Taklamakan Desert
Analyzing the genetic diversity and selection characteristics of sheep (Ovis aries) holds significant value in understanding their environmental adaptability, enhancing breeding efficiency, and achieving effec...
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Article
Open AccessLong-term survivals of immune checkpoint inhibitors as neoadjuvant and adjuvant therapy in dMMR/MSI-H colorectal and gastric cancers
The long-term survival benefit of immune checkpoint inhibitors (ICIs) in neoadjuvant and adjuvant settings is unclear for colorectal cancers (CRC) and gastric cancers (GC) with deficiency of mismatch repair (d...
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Article
A novel method for improving milling efficiency and wear resistance of mill hammer with orderly brazed diamond grains
In order to improve the milling efficiency and wear resistance of hammer mills, diamond grains were brazed onto a T-shaped SUS 304 stainless steel hammer with an orderly patterned arrangement. The impact of gr...
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Article
High Hydrostatic Pressure Exacerbates Bladder Fibrosis through Activating Piezo1
Bladder outlet obstruction (BOO) results in significant fibrosis in the chronic stage and elevated bladder pressure. Piezo1 is a type of mechanosensitive (MS) channel that directly responds to mechanical stimu...
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Article
Centrifuge Modeling of In-Situ Chemical Oxidation for Remediation of Organic Contaminated Soil
In-situ chemical oxidation (ISCO) has been widely utilized for the remediation of organic contaminated soil, while the long-term remediation efficiency and mechanism have been rarely explored, which is of grea...
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Article
Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas
Bruton’s tyrosine kinase (BTK) has emerged as a therapeutic target for B-cell malignancies, which is substantiated by the efficacy of various irreversible or reversible BTK inhibitors. However, on-target BTK m...
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Article
Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial final results
Claudin18.2 (CLDN18.2) is highly expressed with the development of various malignant tumors, especially gastrointestinal cancers, and is emerging as a new target for cancer treatment. Satricabtagene autoleucel...
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Article
Iron-based layered double hydroxide packed with metal–organic frameworks for enhanced overall water-splitting electrocatalysis
Designing hybrid materials with numerous catalytic active sites, high specific surface area, and interfacial interactions is an effective strategy to improve electrocatalytic performance. In this work, iron-ba...
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Article
Studies of an event-building algorithm of the readout system for the twin TPCs in HFRS
The High-energy Fragment Separator (HFRS), which is currently under construction, is a leading international radioactive beam device. Multiple sets of position-sensitive twin time projection chamber (TPC) dete...
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Article
Open AccessA pathological joint–liver axis mediated by matrikine-activated CD4+ T cells
The knee joint has long been considered a closed system. The pathological effects of joint diseases on distant organs have not been investigated. Herein, our clinical data showed that post-traumatic joint dama...
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Article
Effect of humic acid on visible light photocatalytic inactivation of bacteriophage f2 with electrospinning Cu-TiO2 nanofibers: insight into the mechanisms
Photocatalytic disinfection is a promising technology with low cost and high efficiency. However, most of the current studies on photocatalytic disinfection ignore the widespread presence of natural organic ma...
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Article
Enantioselective propargylic amination and related tandem sequences to α-tertiary ethynylamines and azacycles
Chiral α-tertiary amines and related azacycles are sought-after compounds for drug development. Despite progress in the catalytic asymmetric construction of aza-quaternary stereocentres, enantioselective synth...
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Article
Open AccessPlasma Amino Acid Profile in Children with Autism Spectrum Disorder in Southern China: Analysis of 110 Cases
To retrospectively explore the characteristics of plasma amino acids (PAAs) in children with autism spectrum disorder and their clinical association via case-control study. A total of 110 autistic and 55 healt...
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Article
Open AccessNADPH oxidase 2 mediates cardiac sympathetic denervation and myocyte autophagy, resulting in cardiac atrophy and dysfunction in doxorubicin-induced cardiomyopathy
Doxorubicin has been used extensively as a potent anticancer agent, but its clinical use is limited by its cardiotoxicity. However, the underlying mechanisms remain to be fully elucidated. In this study, we te...
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Article
Open AccessHeavy baryon decays into light meson and dark baryon within LCSR
We studied the decays of Heavy baryon into a pseudoscalar meson and a dark baryon in the recently developed B-Mesogenesis scenario, where the two types of effective Lagrangians proposed by the scenario are both c...
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Article
Open AccessA von-Neumann-like photonic processor and its application in studying quantum signature of chaos
Photonic quantum computation plays an important role and offers unique advantages. Two decades after the milestone work of Knill-Laflamme-Milburn, various architectures of photonic processors have been propose...
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Article
Open AccessLanGui tea, an herbal medicine formula, protects against binge alcohol-induced acute liver injury by activating AMPK-NLRP3 signaling
LanGui tea, a traditional Chinese medicine formulation comprising of Gynostemma pentaphyllum (Thunb.) Makino, Cinnamomum cassia (L.) J. Presl, and Ampelopsis grossedentata (Hand-Mazz) W.T. Wang, has yet to have i...
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Article
Framework of personalized layout for a museum exhibition hall
In order to generate a highly personalized, interactive and time-independent layout of artifacts in museums, to solve the limitations of real-world museums in terms of places, layouts and exhibition forms, to ...
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Article
Open AccessTransport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain
Bilirubin is mainly generated from the breakdown of heme when red blood cells reach the end of their lifespan. Accumulation of bilirubin in human body usually leads to various disorders, including jaundice and...
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Article
Interface strengthening for thermal sprayed WC-10Co4Cr coating subjected to pulsed magnetic treatment
The reliability of the coated industry components demands ideal fatigue properties of the coating, and it is mainly determined by the performance of the interfaces. In this study, pulsed magnetic treatment (PM...
