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A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity

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  1. Article

    Open Access

    Genetic diversity and prevalence of emerging Rickettsiales in Yunnan Province: a large-scale study

    Rickettsia and related diseases have been identified as significant global public health threats. This study involved comprehensive field and systematic investigations of various rickettsial organisms in Yunna...

    Chun-Hong Du, Rong **ang, Shuang-Shuang Bie, **ng Yang in Infectious Diseases of Poverty (2024)

  2. Article

    Open Access

    Population structure and selection signal analysis of indigenous sheep from the southern edge of the Taklamakan Desert

    Analyzing the genetic diversity and selection characteristics of sheep (Ovis aries) holds significant value in understanding their environmental adaptability, enhancing breeding efficiency, and achieving effec...

    Zhi-peng Han, Rui-zhi Yang, Wen Zhou, Lu-lu Zhang, Jie-ru Wang in BMC Genomics (2024)

  3. Article

    Open Access

    Artificial sweeteners and risk of incident cardiovascular disease and mortality: evidence from UK Biobank

    Artificial sweeteners are widely popular worldwide as substitutes for sugar or caloric sweeteners, but there are still several important unknowns and controversies regarding their associations with cardiovascu...

    Tao Sun, Juan Yang, Fang Lei, Xuewei Huang, Weifang Liu in Cardiovascular Diabetology (2024)

  4. Article

    Open Access

    Aggravating effect of abnormal low-density protein cholesterol level on coronary atherosclerotic plaque in type 2 diabetes mellitus patients assessed by coronary computed tomography angiography

    The abnormal low-density protein cholesterol (LDL-C) level in the development of atherosclerosis is often comorbid in individuals with type 2 diabetes mellitus(T2DM). This study aimed to investigate the aggrav...

    Yi-Ning Jiang, Yue Gao, Yu-Shan Zhang, Chen-Yan Min in Cardiovascular Diabetology (2024)

  5. Article

    Open Access

    Myricetin mitigates motor disturbance and decreases neuronal ferroptosis in a rat model of Parkinson’s disease

    Ferroptosis is an iron-dependent cell death form characterized by reactive oxygen species (ROS) overgeneration and lipid peroxidation. Myricetin, a flavonoid that exists in numerous plants, exhibits potent ant...

    Si-Chun Gu, Zhi-Guo **e, Min-Jue Gu, Chang-De Wang, Li-Min Xu in Scientific Reports (2024)

  6. Article

    Open Access

    Notoginsenoside R1 promotes Lgr5+ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling

    Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal barrier and excessive inflammation, leading to increased intestinal permeability. Current treatments of IBD primarily ad...

    Zhi-lun Yu, Rui-yang Gao, Cheng Lv, **ao-long Geng in Acta Pharmacologica Sinica (2024)

  7. Article

    Open Access

    Nonlinear association between atherogenic index of plasma and type 2 diabetes mellitus in overweight and obesity patients: evidence from Chinese medical examination data

    The atherogenic index of plasma (AIP) is closely associated with the onset of diabetes, with obesity being a significant risk factor for type 2 diabetes mellitus (T2DM). However, the association between the AI...

    Yongbing Sun, Fengli Li, Yang Zhou, Ao Liu, **nbei Lin in Cardiovascular Diabetology (2024)

  8. Article

    Open Access

    MRI radiomics enhances radiologists’ ability for characterizing intestinal fibrosis in patients with Crohn’s disease

    We aimed to develop MRI-based radiomic models (RMs) to improve the diagnostic accuracy of radiologists in characterizing intestinal fibrosis in patients with Crohn’s disease (CD).

    Mengchen Zhang, Yinghou Zeng, Zhuang-nian Fang, Yang-di Wang in Insights into Imaging (2024)

  9. Article

    Open Access

    Effects of non-pharmacological interventions for adults with subjective cognitive decline: a network meta-analysis and component network meta-analysis

    Non-pharmacological interventions have a myriad of available intervention options and contain multiple components. Whether specific components of non-pharmacological interventions or combinations are superior ...

    **ao-Hong Yu, **n-Ru Li, Zhi-Run Du, Yu Zhang, Yang Fei, Wen-** Tang in BMC Medicine (2024)

  10. Article

    Open Access

    Nicotinate-curcumin improves NASH by inhibiting the AKR1B10/ACCα-mediated triglyceride synthesis

    Nonalcoholic steatohepatitis (NASH) is a prevalent chronic liver condition. However, the potential therapeutic benefits and underlying mechanism of nicotinate-curcumin (NC) in the treatment of NASH remain unce...

    **u-lian Lin, Ya-ling Zeng, Jie Ning, Zhe Cao, Lan-lan Bu in Lipids in Health and Disease (2024)

  11. Article

    Open Access

    Electrophysiological characteristics and catheter ablation of ventricular arrhythmias arising from the superior septal left ventricle

    Electrophysiological characteristics and radiofrequency catheter ablation (RFCA) of premature ventricular contractions (PVCs) originating from the superior septal left ventricle (SSLV) have not yet been fully ...

    Qifang Liu, Ye Tian, Zhi Jiang, Longhai Tian, **g Huang in BMC Cardiovascular Disorders (2024)

  12. Article

    Open Access

    Assessment of subclinical LV myocardial dysfunction in T2DM patients with diabetic peripheral neuropathy: a cardiovascular magnetic resonance study

    Diabetic peripheral neuropathy (DPN) is the most prevalent complication of diabetes, and has been demonstrated to be independently associated with cardiovascular events and mortality. This aim of this study wa...

    Xue-Ming Li, Ke Shi, Li Jiang, **g Wang, Wei-Feng Yan in Cardiovascular Diabetology (2024)

  13. Article

    Open Access

    LINC00525 enhances ZNF460-regulated CD24 expression through the sponge miR-125a-5p to promote malignant progression of breast cancer

    CD24 is a highly glycosylated glycosylphosphatidylinositol anchored membrane protein that plays an important role in tumor progression. The aim of this study was to investigate the effect of abnormal expressio...

    Jun Wang, Ji Shi, Yuan **ang, Zhi-Wen Wang in Journal of Cancer Research and Clinical On… (2024)

  14. Article

    Open Access

    Cold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy

    Recently, environmental temperature has been shown to regulate bone homeostasis. However, the mechanisms by which cold exposure affects bone mass remain unclear. In our present study, we observed that exposure...

    Li-Min Lei, Fu-**ng-Zi Li, **ao Lin, Feng Xu, Su-Kang Shan in Journal of Nanobiotechnology (2024)

  15. Article

    Open Access

    Nanoconfinement steers nonradical pathway transition in single atom fenton-like catalysis for improving oxidant utilization

    The introduction of single-atom catalysts (SACs) into Fenton-like oxidation promises ultrafast water pollutant elimination, but the limited access to pollutants and oxidant by surface catalytic sites and the i...

    Yan Meng, Yu-Qin Liu, Chao Wang, Yang Si, Yun-Jie Wang, Wen-Qi **a in Nature Communications (2024)

  16. Article

    Open Access

    Effect of probiotics on children with autism spectrum disorders: a meta-analysis

    Researches have found that alteration of intestinal flora may be closely related to the development of autism spectrum disorder (ASD). However, whether probiotics supplementation has a protective effect on ASD...

    ** Zeng, Cheng-zhi Zhang, Zhi-xing Fan, Chao-jun Yang in Italian Journal of Pediatrics (2024)

  17. Article

    Open Access

    Additive effect of admission hyperglycemia on left ventricular stiffness in patients following acute myocardial infarction verified by CMR tissue tracking

    Stress hyperglycemia occurs frequently in patients following acute myocardial infarction (AMI) and may aggravate myocardial stiffness, but relevant evidence is still lacking. Accordingly, this study aimed to e...

    Pei-Lun Han, Kang Li, Yu Jiang, Yue Gao, Ying-Kun Guo in Cardiovascular Diabetology (2024)

  18. Article

    Open Access

    Radiomic analysis based on magnetic resonance imaging for the prediction of VEGF expression in hepatocellular carcinoma patients

    The purpose of this study was to investigate the ability of radiomic characteristics of magnetic resonance images to predict vascular endothelial growth factor (VEGF) expression in hepatocellular carcinoma (HC...

    Cui Yang, Ze-Ming Zhang, Zhang-** Zhao, Zhi-Qing Wang, **g Zheng in Abdominal Radiology (2024)

  19. Article

    Open Access

    Noninvasive prediction of lymph node metastasis in pancreatic cancer using an ultrasound-based clinicoradiomics machine learning model

    This study was designed to explore and validate the value of different machine learning models based on ultrasound image-omics features in the preoperative diagnosis of lymph node metastasis in pancreatic canc...

    Dong-yue Wen, Jia-min Chen, Zhi-** Tang, **-shu Pang in BioMedical Engineering OnLine (2024)

  20. Article

    Open Access

    CSPG4P12 polymorphism served as a susceptibility marker for esophageal cancer in Chinese population

    Chondroitin sulfate proteoglycan 4 pseudogene 12 (CSPG4P12) has been implicated in the pathogenesis of various cancers. This study aimed to evaluate the association of the CSPG4P12 polymorphism with esophageal sq...

    Hongxue Xu, Zhenbang Yang, Wenqian Hu, **anlei Zhou, Zhi Zhang, Xuemei Zhang in BMC Cancer (2024)

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