69 Result(s)

Article

Notoginsenoside R1 promotes Lgr5⁺ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling

Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal barrier and excessive inflammation, leading to increased intestinal permeability. Current treatments of IBD primarily ad...

Zhi-lun Yu, Rui-yang Gao, Cheng Lv, **ao-long Geng… in Acta Pharmacologica Sinica (2024)

Article

Canagliflozin alleviates pulmonary hypertension by activating PPARγ and inhibiting its S225 phosphorylation

Pulmonary hypertension (PH) is a progressive fatal disease with no cure. Canagliflozin (CANA), a novel medication for diabetes, has been found to have remarkable cardiovascular benefits. However, few studies h...

**u-chun Li, **a-yan Zhu, Yang-yue Wang, Shuo-lan Tong… in Acta Pharmacologica Sinica (2024)

Article

GPR84 regulates pulmonary inflammation by modulating neutrophil functions

Acute lung injury (ALI) is an acute, progressive hypoxic respiratory failure that could develop into acute respiratory distress syndrome (ARDS) with very high mortality rate. ALI is believed to be caused by un...

Si-wei Wang, Qing Zhang, Dan Lu, You-chen Fang, **ao-ci Yan… in Acta Pharmacologica Sinica (2023)

Article

A Cohort Study on Deficiency of ADA2 from China

Deficiency of adenosine deaminase 2 (DADA2), an autosomal recessive autoinflammatory disorder caused by biallelic loss-of-function variants in adenosine deaminase 2 (ADA2), has not been systemically investigat...

Guo-min Li, Xu Han, Ye Wu, Wei Wang, Hong-xia Tang… in Journal of Clinical Immunology (2023)

Article

DrugRep: an automatic virtual screening server for drug repurposing

Computationally identifying new targets for existing drugs has drawn much attention in drug repurposing due to its advantages over de novo drugs, including low risk, low costs, and rapid pace. To facilitate th...

Jian-hong Gan, Ji-xiang Liu, Yang Liu, Shu-wen Chen… in Acta Pharmacologica Sinica (2023)

Article

NFAT inhibitor 11R-VIVIT ameliorates mouse renal fibrosis after ischemia-reperfusion-induced acute kidney injury

Acute kidney injury (AKI) with maladaptive tubular repair leads to renal fibrosis and progresses to chronic kidney disease (CKD). At present, there is no curative drug to interrupt AKI-to-CKD progression. The ...

Zhi-yong **e, Wei Dong, Li Zhang, Meng-jie Wang… in Acta Pharmacologica Sinica (2022)

Article

Tetrandrine alleviates silicosis by inhibiting canonical and non-canonical NLRP3 inflammasome activation in lung macrophages

Silicosis caused by inhalation of silica particles leads to more than ten thousand new occupational exposure-related deaths yearly. Exacerbating this issue, there are currently few drugs reported to effectivel...

Mei-yue Song, Jia-xin Wang, You-liang Sun, Zhi-fa Han… in Acta Pharmacologica Sinica (2022)

Article

Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma

HDAC inhibitors (HDACis) have been intensively studied for their roles and potential as drug targets in T-cell lymphomas and other hematologic malignancies. Bisthianostat is a novel bisthiazole-based pan-HDACi...

Yu-bo Zhou, Yang-ming Zhang, Hong-hui Huang, Li-**g Shen… in Acta Pharmacologica Sinica (2022)

Article

Advanced biomaterials for cancer immunotherapy

Immunotherapy, as a powerful strategy for cancer treatment, has achieved tremendous efficacy in clinical trials. Despite these advancements, there is much to do in terms of enhancing therapeutic benefits and d...

Fan Yang, Kun Shi, Yan-peng Jia, Ying Hao, **-rong Peng… in Acta Pharmacologica Sinica (2020)

Article

Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice

Non-alcoholic fatty liver disease (NAFLD) is a clinical syndrome characterized by hepatic steatosis. NAFLD is closely linked to obesity, insulin resistance and dyslipidemia. AMP-activated protein kinase (AMPK)...

Mei Zhang, Zhi-fu **e, Run-tao Zhang, Da-kai Chen, Min Gu… in Acta Pharmacologica Sinica (2018)

Article

miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges

Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the world. Although considerable progress has been made in the diagnosis, treatment and prognosis of CVD, there is still a crit...

Shan-shan Zhou, **g-peng **, Ji-qun Wang, Zhi-guo Zhang… in Acta Pharmacologica Sinica (2018)

Article

Pharmacokinetic and metabolomic analyses of the neuroprotective effects of salvianolic acid A in a rat ischemic stroke model

Salvianolic acid A (SAA), a water-soluble phenolic acid isolated from the root of Dan Shen, displays distinct antioxidant activity and effectiveness in protection against cerebral ischemia/reperfusion (I/R) da...

Si-qi Feng, Nan Aa, Jian-liang Geng, **g-qiu Huang… in Acta Pharmacologica Sinica (2017)

Article

Sesamin alleviates blood-brain barrier disruption in mice with experimental traumatic brain injury

Sesamin, a major lignan of sesame oil, was reported to have neuroprotective effects in several brain injury models. However, its protective action in maintaining blood-brain barrier (BBB) integrity has not bee...

Ying-liang Liu, Zhi-ming Xu, Guo-yuan Yang, Dian-xu Yang… in Acta Pharmacologica Sinica (2017)

Article

LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy

Alzheimer's disease (AD) is a progressive neurodegenerative disease leading to the irreversible loss of brain neurons and cognitive abilities, and the vicious interplay between oxidative stress (OS) and tauopa...

**ao-dan Guo, Guang-long Sun, Ting-ting Zhou, Yi-yang Wang… in Acta Pharmacologica Sinica (2017)

Article

Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-Raf^V600E inhibitors

The mutation of B-Raf^V600E is widespread in a variety of human cancers. Its inhibitors vemurafenib and dabrafenib have been launched as drugs for treating unresectable melanoma, demonstrating that B-Raf^V600E is a...

Gui-min Wang, **ang Wang, Jian-ming Zhu, Bin-bin Guo… in Acta Pharmacologica Sinica (2017)

Article

Two birds, one stone: dual targeting of the cancer cell surface and subcellular mitochondria by the galectin-3-binding peptide G3-C12

Active tumor-targeting approaches using specific ligands have drawn considerable attention over the years. However, a single ligand often fails to simultaneously target the cancer cell surface and subcellular ...

Wei Sun, Lian Li, Li-jia Li, Qing-qing Yang, Zhi-rong Zhang… in Acta Pharmacologica Sinica (2017)

Article

The Chk1 inhibitor MK-8776 increases the radiosensitivity of human triple-negative breast cancer by inhibiting autophagy

MK-8776 is a recently described inhibitor that is highly selective for checkpoint kinase 1 (Chk1), which can weaken the DNA repair capacity in cancer cells to achieve chemo-sensitization. A number of studies s...

Zhi-rui Zhou, Zhao-zhi Yang, Shao-jia Wang, Li Zhang… in Acta Pharmacologica Sinica (2017)

Article

A novel matrine derivate inhibits differentiated human hepatoma cells and hepatic cancer stem-like cells by suppressing PI3K/AKT signaling pathways

Matrine is an alkaloid extracted from a Chinese herb Sophora flavescens Ait, which has shown chemopreventive potential against various cancers. In this study, we evaluated the anticancer efficacy of a novel de...

Ying Liu, Yang Qi, Zhi-hui Bai, Chen-xu Ni, Qi-hui Ren… in Acta Pharmacologica Sinica (2017)

Article

Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities

CD97 belongs to the adhesion GPCR family characterized by a long ECD linked to the 7TM via a GPCR proteolytic site (GPS) and plays important roles in modulating cell migration and invasion. CD97 (EGF1-5) is a ...

Li-yun Yang, **ao-fang Liu, Yang Yang, Lin-lin Yang… in Acta Pharmacologica Sinica (2017)

Article

Erratum to: Clinical and Molecular Features of 38 Children with Chronic Granulomatous Disease in Mainland China

Huan Xu, Wen Tian, Shu-Juan Li, Lu-Ying Zhang, Wei Liu… in Journal of Clinical Immunology (2017)