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Article
Open AccessChemotherapy-induced PTEN-L secretion promotes the selection of PTEN-deficient tumor cells
PTEN loss has been identified in various tumor types and is linked to unfavorable clinical outcomes. In addition to PTEN mutation, multiple mechanisms contribute to PTEN loss during tumor development. However,...
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Article
Perfluoroalkyl substance exposure is associated with asthma and innate immune cell count in US adolescents stratified by sex
Exposure to perfluoroalkyl substances (PFAS) may be harmful to humans; however, previous studies have been inconsistent regarding the potential for PFAS-induced immunosuppresion. This study explored the relati...
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Article
Effect of allergic rhinitis on sleep in children and the risk factors of an indoor environment
Allergic rhinitis (AR) is an independent risk factor for sleep disorders in children, including abnormal sleep behaviors. We investigated the occurrence of abnormal sleep behaviors in children with AR to deter...
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Article
Open AccessCholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression
The use of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) brings remarkable benefits for the survival of patients with advanced NSCLC harboring EGFR mutations. Unfortunately, acquired ...
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Article
Open AccessClaudin1 decrease induced by 1,25-dihydroxy-vitamin D3 potentiates gefitinib resistance therapy through inhibiting AKT activation-mediated cancer stem-like properties in NSCLC cells
Claudins, the integral tight junction proteins that regulate paracellular permeability and cell polarity, are frequently dysregulated in cancer; however, their roles in regulating EGFR tyrosine kinase inhibito...
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Article
Open AccessHPV16 E6 gene polymorphisms and the functions of the mutation site in cervical cancer among Uygur ethnic and Han nationality women in **njiang, China
To investigate the genotype distribution of human papillomavirus (HPV) in infected Uygur and Han women in **njiang, China; analyze the HPV16 E6 gene polymorphism site and relationship with the development of c...
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Article
Open AccessSpontaneous formation of neutrophil extracellular traps is associated with autophagy
Neutrophils release neutrophil extracellular traps (NETs), via NETosis, as a defense mechanism against pathogens. Neutrophils can release NETs spontaneously; however, the mechanisms underlying spontaneous NETo...
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Article
Sex Difference Between Trace Elements and Pulmonary Functions in Children
It has been defined that deficiency of trace elements plays an important role in the progression of asthma. However, the relationship between blood zinc (Zn), selenium (Se), and magnesium (Mg) and pulmonary fu...
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Article
Open Access1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells
Recent studies have demonstrated that acquisition of cancer stem-like properties plays an essential role in promoting epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) resistance in non-s...
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Article
Open AccessCharacteristics and risk factors of children with sleep-disordered breathing in Wuxi, China
Sleep-disordered breathing (SDB) is a common syndrome in children, related to their immune responses, cardiovascular function, and neurocognitive function. This study aimed to determine the prevalence of SDB a...
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Article
Effects of Lead, Mercury, and Cadmium Co-exposure on Children’s Pulmonary Function
Accumulating evidence has shown that toxic metals exposure can have adverse effects on children, but the effects of blood Pb, Hg, and Cd co-exposure on pulmonary function in children remains to be clarified. T...
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Article
Open AccessCD90 serves as differential modulator of subcutaneous and visceral adipose-derived stem cells by regulating AKT activation that influences adipose tissue and metabolic homeostasis
White adipose tissue includes subcutaneous and visceral adipose tissue (SAT and VAT) with different metabolic features. SAT protects from metabolic disorders, while VAT promotes them. The proliferative and adi...
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Article
Open AccessGenetic variations in E6, E7 and the long control region of human papillomavirus type 16 among patients with cervical lesions in **njiang, China
**njiang is one of the areas with the highest incidence of cervical cancer in China. Genetic variation in Human papillomavirus type 16 (HPV16) may increase the ability of the virus to mediate carcinogenesis an...
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Article
Open AccessScreening for HPV infection in exfoliated cervical cells of women from different ethnic groups in Yili, **njiang, China
We investigated the infection status and genotype distribution of human papillomavirus (HPV) in women of different ages and various ethnic groups in the Yili region, **njiang, China. We checked the HPV genotyp...
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Article
Open AccessMiR-544 promotes immune escape through downregulation of NCR1/NKp46 via targeting RUNX3 in liver cancer
To study the potential role of miR-544 in the immune escape mechanism of hepatoma cells.
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Article
Open AccessTIPE3 differentially modulates proliferation and migration of human non-small-cell lung cancer cells via distinct subcellular location
TIPE3 (TNFAIP8L3), a transfer protein for lipid second messengers, is upregulated in human lung cancer tissues. The most popular lung cancer is non-small cell lung cancer (NSCLC) with high incidences and low s...
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Article
Open AccessVariants of human papillomaviruses 16 (HPV16) in Uigur women in **njiang, China
Persistent infection of high-risk human papillomaviruses 16 (HPV16) has been considered as the leading cause of cervical cancer. In this study we assessed HPV16 sequence variation and genetic diversity of HPV1...
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Article
Imperatorin acts as a cisplatin sensitizer via downregulating Mcl-1 expression in HCC chemotherapy
Acquisition of cisplatin resistance is the common and critical limitation for hepatocellular carcinoma (HCC) therapy. Our study was aimed to determine whether there were conditions under which the addition of ...
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Article
Reevaluation of glypican-3 as a prognostic marker in HCC using X-tile software
Glypican-3 (GPC3) is a widely used immunohistochemical marker for hepatocellular carcinoma (HCC); however, its prognostic value is unclear. Immunohistochemical evaluation of GPC3 expression was performed on 30...
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Article
Open AccessA visible metamaterial fabricated by self-assembly method
A visible negative-index metamaterial was fabricated by adopting a template-assisted and self-assembled electrochemical deposition method. Originating from the inherent characteristic of bottom-up fabrication,...
