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Article
Open AccessProbabilistic sunspot predictions with a gated recurrent units-based combined model guided by pinball loss
Sunspots play a crucial role in both weather forecasting and the monitoring of solar storms. In this work, we propose a novel combined model for sunspot prediction using improved gated recurrent units (GRU) gu...
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Article
Open AccessTargeting pathogenic CD8+ tissue-resident T cells with chimeric antigen receptor therapy in murine autoimmune cholangitis
Primary biliary cholangitis (PBC) is a cholestatic autoimmune liver disease characterized by autoreactive T cell response against intrahepatic small bile ducts. Here, we use Il12b-/-Il2ra-/- mice (DKO mice) as a ...
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Article
Continuous age- and sex-specific reference ranges of liver enzymes in Chinese children and application in pediatric non-alcoholic fatty liver disease
Alanine aminotransferase (ALT) is widely used to screen patients with hepatic diseases. However, the current reference ranges (< 50 U/L) were developed by laboratories and have not been validated in population...
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Article
Open AccessSystematic pan-cancer analyses of the potential function of the Golgi scaffold protein PAQR3
Progesterone and AdipoQ Receptor 3 (PAQR3) is a member of the AdipoQ receptor. Our previous studies have found that PAQR3 plays a role as a candidate inhibitor in cardiac adenocarcinoma, breast cancer, gastric...
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Article
Single-Cell Analysis of Patients with Axial Spondyloarthritis After Anti-TNFα Treatment: Experimental Data and Review of the Literature
Axial spondyloarthritis (Ax-SpA) is a chronic inflammatory disease that predominantly affects the axial joints and is most common in young men. However, the precise immune cell subset involved in Ax-SpA remain...
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Article
Open AccessEfficacy and safety profile of angiotensin receptor neprilysin inhibitors in the management of heart failure: a systematic review and meta-analysis of randomized controlled trials
Several guidelines have recommended the use of angiotensin receptor neprilysin inhibitors (ARNIs) as replacement for angiotensin-converting enzyme inhibitors in the management of heart failure. Till date, ther...
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Open AccessCorrection: Comprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica
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Open AccessComprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica
Primary gastric linitis plastica (GLP) is a distinct phenotype of gastric cancer with poor survival. Comprehensive molecular profiles and putative therapeutic targets of GLP remain undetermined.
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Article
Free-space dissemination of time and frequency with 10−19 instability over 113 km
Networks of optical clocks find applications in precise navigation1,2, in efforts to redefine the fundamental unit of the ‘second’3–6 and in gravitational tests7. As the frequency instability for state-of-the-art...
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Article
Open AccessNotch signaling mutations increase intra-tumor chemokine expression and predict response to immunotherapy in colorectal cancer
The Notch signaling mutation is associated with enhanced anti-tumor immune response in colorectal cancer (CRC). In this study, we aim to investigate the underlying mechanism and the predictive potential of Not...
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Article
Open AccessGradually shifting clinical phenomics in migraine spectrum: a cross-sectional, multicenter study of 5438 patients
The aim of the study was to investigate whether MwoA and MwA are different manifestations of a single disease, distinct clinical entities, or located at two poles of a spectrum.
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Article
An accessible strategy for high-performance copper layer fabrication on polyphenylene oxide substrates via polydopamine functionalization and electroless deposition
A facile and effective approach to fabricate a high-performance copper layer on polyphenylene oxide (PPO) substrate via electroless deposition for applications in the high-frequency circuit board is introduced...
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Article
Open AccessGene co-expression network based on part mutual information for gene-to-gene relationship and gene-cancer correlation analysis
Finding correlation patterns is an important goal of analyzing biological data. Currently available methods for correlation analysis mainly use non-direct associations, such as the Pearson correlation coeffici...
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Article
Open AccessChromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity
Activation of adipose tissue macrophages (ATMs) contributes to chronic inflammation and insulin resistance in obesity. However, the transcriptional regulatory machinery involved in ATM activation during the de...
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Article
Effect of mould baffle technology on stray grain formation in single crystal blades by integral fabrication based on 3D printing
Stray grains, the most serious casting defect, mainly occur in the platform because of the abrupt transition of the cross-section in the directional solidification of superalloy single-crystal blades. A new mo...
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Article
Detection of the interictal epileptic discharges based on wavelet bispectrum interaction and recurrent neural network
Detection of interictal epileptic discharges (IED) events in the EEG recordings is a critical indicator for detecting and diagnosing epileptic seizures. We propose a key technology to extract the most importan...
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Article
Immunobiology of T Cells in Sjögren’s Syndrome
Sjögren’s syndrome (SjS) is a systemic autoimmune disease marked by xerostomia (dry mouth), keratoconjunctivitis sicca (eye dryness), and other systematic disorders. Its pathogenesis involves an inflammatory p...
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Article
Replication study and meta-analysis indicate a suggestive association of RUNX3 locus with primary biliary cholangitis
Susceptibility to primary biliary cholangitis (PBC) is in part genetically determined. In our previous PBC genome-wide association study (GWAS) in 1118 Han Chinese PBC and 4036 controls, we noted that multiple...
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Article
Open AccessMulti-omics analysis identifies FoxO1 as a regulator of macrophage function through metabolic reprogramming
Macrophages are plastic cells that can switch among different states according to bioenergetic or biosynthetic requirements. Our previous work demonstrated that the transcription factor Forkhead Box Protein 1 (Fo...
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Article
Animal Models of Autoimmune Liver Diseases: a Comprehensive Review
Autoimmune liver diseases (AILDs) are potentially life-threatening chronic liver diseases which include autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and recently character...
