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Article
Author Correction: Disease-associated astrocyte epigenetic memory promotes CNS pathology
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Article
Disease-associated astrocyte epigenetic memory promotes CNS pathology
Disease-associated astrocyte subsets contribute to the pathology of neurologic diseases, including multiple sclerosis and experimental autoimmune encephalomyelitis1–8 (EAE), an experimental model for multiple scl...
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Article
Open AccessAnnoPRO: a strategy for protein function annotation based on multi-scale protein representation and a hybrid deep learning of dual-path encoding
Protein function annotation has been one of the longstanding issues in biological sciences, and various computational methods have been developed. However, the existing methods suffer from a serious long-tail ...
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Article
Open AccessPaired yeast one-hybrid assays to detect DNA-binding cooperativity and antagonism across transcription factors
Cooperativity and antagonism between transcription factors (TFs) can drastically modify their binding to regulatory DNA elements. While map** these relationships between TFs is important for understanding th...
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Article
Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells
Dendritic cells (DCs) have a role in the development and activation of self-reactive pathogenic T cells1,2. Genetic variants that are associated with the function of DCs have been linked to autoimmune disorders3,
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Article
B-cell-specific checkpoint molecules that regulate anti-tumour immunity
The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth1,2. Here, using high-throughput flow cy...
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Article
Identification of astrocyte regulators by nucleic acid cytometry
Multiple sclerosis is a chronic inflammatory disease of the central nervous system1. Astrocytes are heterogeneous glial cells that are resident in the central nervous system and participate in the pathogenesis of...
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Chapter and Conference Paper
Clinical Coding Based on Knowledge Enhanced Language Model and Attention Pooling
Clinical coding is obtaining a standard ICD code based on the patient’s electronic medical record (EMR) information, including diagnosis, procedure, drug list, order, etc. It is essential in the medical record...
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Article
Identification of environmental factors that promote intestinal inflammation
Genome-wide association studies have identified risk loci linked to inflammatory bowel disease (IBD)1—a complex chronic inflammatory disorder of the gastrointestinal tract. The increasing prevalence of IBD in ind...
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Article
Optimization of metabolomic data processing using NOREVA
A typical output of a metabolomic experiment is a peak table corresponding to the intensity of measured signals. Peak table processing, an essential procedure in metabolomics, is characterized by its study dep...
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Article
Open AccessAHR signaling is induced by infection with coronaviruses
Coronavirus infection in humans is usually associated to respiratory tract illnesses, ranging in severity from mild to life-threatening respiratory failure. The aryl hydrocarbon receptor (AHR) was recently ide...
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Article
Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease
Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal tract. Extracellular adenosine triphosphate (eATP) produced by the commensal microbiota and host cells activa...
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Article
Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that have important homeostatic and disease-promoting functions1. However, little is known about the homeostatic anti-inflammat...
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Article
Author Correction: AHR is a Zika virus host factor and a candidate target for antiviral therapy
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
The effects of vegetation restoration strategies and seasons on soil enzyme activities in the Karst landscapes of Yunnan, southwest China
Soil enzymes play a vital role in biogeochemical cycling and ecosystem functions. In this study, we examined the response of six soil enzymes to changes in physicochemical properties resulting from changes in ...
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Article
AHR is a Zika virus host factor and a candidate target for antiviral therapy
Zika virus (ZIKV) is a flavivirus linked to multiple birth defects including microcephaly, known as congenital ZIKV syndrome. The identification of host factors involved in ZIKV replication may guide efficacio...
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Article
MAFG-driven astrocytes promote CNS inflammation
Multiple sclerosis is a chronic inflammatory disease of the CNS1. Astrocytes contribute to the pathogenesis of multiple sclerosis2, but little is known about the heterogeneity of astrocytes and its regulation. He...
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Article
Achieving data-driven actionability by combining learning and planning
A main focus of machine learning research has been improving the generalization accuracy and efficiency of prediction models. However, what emerges as missing in many applications is actionability, i.e., the a...
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Article
Preliminary Development of the Elementary School Students’ Subjective Well-Being in School Scale
The aim of the present study was to develop a scale to measure elementary school students’ subjective well-being (SWB) in school. Based on the tripartite model of SWB in school, this study developed three subs...
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Article
miR-99a and -99b inhibit cervical cancer cell proliferation and invasion by targeting mTOR signaling pathway
MicroRNAs were demonstrated to play an important role in the regulation of gene expression. Here, we showed that miR-99a and -99b (miR-99a/b) were down-regulated in human cervical cancer patient tissues and we...
