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Article
A Novel CA4P Polymeric Nanoparticle for Murine Hepatoma Therapy
Combretastatin A4 phosphate (CA4P) is a potent vascular disrupting agent with good water solubility. However, it is only effective at high doses, which decreases clinical applicability. Herein, we designed sta...
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Article
IL-2-loaded Polypeptide Nanoparticles for Enhanced Anti-cancer Immunotherapy
Interleukin 2 (IL-2) is widely used as an active immunotherapeutic agent in clinical metastatic cancers. However, its therapeutic concentrations do not last long due to its short half-life. Thus, only a transi...
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Article
Open AccessSubgenome-aware analyses suggest a reticulate allopolyploidization origin in three Papaver genomes
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Article
Open AccessCorrection to: Long non-coding RNA H19 regulates FOXM1 expression by competitively binding endogenous miR-342-3p in gallbladder cancer
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Article
Functional Amphiphilic Poly(2-oxazoline) Block Copolymers as Drug Carriers: the Relationship between Structure and Drug Loading Capacity
Poly(2-oxazoline) (POx) is a kind of polymeric amides that can be viewed as conformational isomers of polypeptides with excellent cyto- and hemo-compatibility, and is promising to be used as drug carriers. How...
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Article
DAPK1 (death associated protein kinase 1) mediates mTORC1 activation and antiviral activities in CD8+ T cells
Mechanistic target of rapamycin complex 1 (mTORC1) regulates CD8+ T-cell differentiation and function. Despite the links between PI3K-AKT and mTORC1 activation in CD8+ T cells, the molecular mechanism underlying ...
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Article
Open AccessDifferent training durations and styles of tai chi for glucose control in patients with type 2 diabetes: a systematic review and meta-analysis of controlled trials
Physical activity is an important part of the diabetes management plan. However, the effects caused by different training durations and styles of Tai Chi have not been evaluated. We conducted an updated system...
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Article
Interactive image segmentation with a regression based ensemble learning paradigm
To achieve fine segmentation of complex natural images, people often resort to an interactive segmentation paradigm, since fully automatic methods often fail to obtain a result consistent with the ground truth...
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Article
Open AccessLong non-coding RNA H19 regulates FOXM1 expression by competitively binding endogenous miR-342-3p in gallbladder cancer
Long non-coding RNA (lncRNA) H19 has been reported to involve in many kinds of human cancers and functions as an oncogene. Our previous study found that H19 was over-expressed in gallbladder cancer (GBC) and w...
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Article
Open AccessHigher proliferation of peritumoral endothelial cells to IL-6/sIL-6R than tumoral endothelial cells in hepatocellular carcinoma
This study aimed to explore the responses to the interleukin-6 (IL-6)/soluble interleukin-6 receptor (sIL-6R) complex in peritumoral endothelial cells (PECs) and tumor endothelial cells (TECs), as well as dete...
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Article
Efficient side-chain modification of dextran via base-catalyzed epoxide ring-opening and thiol-ene click chemistry in aqueous media
In this study, a novel approach by combining base-catalyzed epoxide ring-opening and thiol-ene click chemistry is presented for the side-chain modification of dextran. The vinyl-modified dextran is prepared by...
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Article
Thermosensitive polyion complex micelles prepared by self-assembly of two oppositely charged diblock copolymers
Polyion complex (PIC) micelles were spontaneously formed in aqueous solutions through electrostatic interaction between two oppositely charged block copolymers, poly(N-isopropylacrylamide)-b-poly(L-glutamic acid)...
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Article
Polymerization of lactic O-carboxylic anhydride using organometallic catalysts
The ring-opening polymerization of 5-methyl-1,3-dioxolane-2,4-dione (lactic O-carboxylic anhydride, LacOCA) using organometallic complexes, including Co(III) complexes with Schiff base ligands, Tin(II) alphatates...
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Chapter
Multi-view Face Detection Using Six Segmented Rectangular Features
This paper presents a multi-view face detection system which combines skin color detection and adaptive boosting (Adaboost) algorithm. The aim of this combination is to satisfy the accuracy and speed, the two ...
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Article
Decentralized robust control for large scale interconnected uncertain systems with time-delay
For a class of interconnected time-delay uncertain systems satisfing the matching conditions, the sufficient condition for decentralized stabilization feedback control laws is derived based on Lyapunov stabili...
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Chapter and Conference Paper
Optimizing path expressions using navigational algebraic operators
Object-oriented database systems are more and more used in real applications due to their rich data model and query language mixing declarative assertions and navigations. Queries may frequently involve multip...
