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Article
Upregulation of plasmacytoid dendritic cells in glioma
The immune system fails to eradicate established tumors partly due to the induction of immune tolerance within tumor microenvironment. Plasmacytoid dendritic cells (pDCs) play critical roles in regulating immu...
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Article
Lack of association between let-7 binding site polymorphism rs712 and risk of nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is characterized by its highly invasive and metastatic features. Therefore, screening genetic biomarkers of NPC to achieve early diagnose would be of great value for NPC therapy....
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Article
A let-7 KRAS rs712 polymorphism increases colorectal cancer risk
Growing evidence has indicated that polymorphism present in the miRNA binding site of target gene can alter the ability of miRNAs to bind its target gene and modulate the development and progression of cancer....
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Article
A let-7 binding site polymorphism rs712 in the KRAS 3′ UTR is associated with an increased risk of gastric cancer
Recently, single nucleotide polymorphisms in let-7 miRNA binding site in 3′ untranslated region (UTR) of KRAS mRNA have been found to be associated with the cancer risk. In this study, we genotyped the frequency ...