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Article
Open AccessImmune checkpoint inhibitors in Cancer patients with rheumatologic preexisting autoimmune diseases: a systematic review and meta-analysis
Patients with rheumatologic preexisting autoimmune disease (PAD) have not been enrolled in clinical trials of immune checkpoint inhibitors (ICIs). Therefore, the risks and benefits of ICI therapy in such patie...
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Article
Open AccessEfficacy and safety of VEGF/VEGFR inhibitors for platinum-resistant ovarian cancer: a systematic review and meta-analysis of randomized controlled trials
Almost all patients with ovarian cancer will experience relapse and eventually develop platinum-resistant. The poor prognosis and limited treatment options have prompted the search for novel approaches in mana...
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Article
Open AccessEfficacy and safety of PD-1/PD-L1 inhibitors combined with anti-angiogenic therapy for the unresectable hepatocellular carcinoma and the benefit for hepatitis B virus etiology subgroup: a systematic review and meta-analysis of randomized controlled trials
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death, worldwide. The predominant causative factor for HCC is hepatitis B virus (HBV) infection. We conducted a meta-analysis to esti...
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Article
Open AccessThe prognostic role of tumor mutation burden on survival of breast cancer: a systematic review and meta-analysis
As a potential genetic biomarker, tumor mutation burden (TMB) has made progress in numerous tumors. There are limited data regarding TMB and its prognostic role is controversial in breast cancer. This systemat...
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Article
Open AccessSuppression of autophagy through JAK2/STAT3 contributes to the therapeutic action of rhynchophylline on asthma
Asthma is a chronic inflammatory disease characterized by airway remodeling and inflammation. Rhynchophylline is a kind of indole alkaloid isolated from Uncaria rhynchophylla. Here we investigated the effect of r...
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Chapter and Conference Paper
Anti-breast Cancer Components and Their Effects in Ginsenoside Derivatives by Computer Simulation
Breast cancer is one of the most commonly diagnosed malignancies in women and is an important cause of cancer death. In this paper, the anti - breast cancer components of ginsenoside derivatives were studied b...
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Article
UFBP1, a key component in ufmylation, enhances drug sensitivity by promoting proteasomal degradation of oxidative stress-response transcription factor Nrf2
The key component in the UFM1 conjugation system, UFM1-binding and PCI domain-containing protein 1 (UFBP1), regulates many biological processes. Recently it has been shown that low UFBP1 protein level is assoc...
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Article
Open AccessTime-series transcriptome provides insights into the gene regulation network involved in the volatile terpenoid metabolism during the flower development of lavender
Essential oils (EOs) of Lavandula angustifolia, mainly consist of monoterpenoids and sesquiterpenoids, are of great commercial value. The multi-flower spiciform thyrse of lavender not only determines the output o...
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Chapter and Conference Paper
Density Normalization in Density Peak Based Clustering
As a promising clustering approach, the density peak (DP) based algorithm utilizes the data density and carefully designed distance to identify cluster centers and cluster members. The key to this approach is ...
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Article
Mechanistic examination of causes for narrow distribution in an endangered shrub: a comparison of its responses to drought stress with a widespread congeneric species
The endangered status and narrow distribution in Syringa pinnatifolia , a sub-alpine shrub species, were primarily caused by its poor drought adaptation rela...
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Article
Open AccessDioscorea bulbifera polysaccharide and cyclophosphamide combination enhances anti-cervical cancer effect and attenuates immunosuppression and oxidative stress in mice
Cyclophosphamide (CTX) is commonly used in cancer chemotherapy, which causes immunosuppression and tissue oxidative stress at high doses. As potential protective agents, some polysaccharides were shown to have...
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Chapter and Conference Paper
Dominant Set Based Data Clustering and Image Segmentation
Clustering is an important approach in image segmentation. While various clustering algorithms have been proposed, the majority of them require one or more parameters as input, making them a little inflexible ...
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Chapter and Conference Paper
Cluster Merging Based on Dominant Sets
As an important unsupervised learning approach, clustering is widely used in pattern recognition, information retrieval and image analysis, etc. In various clustering approaches, graph based clustering has rec...
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Chapter and Conference Paper
Research on Low Altitude Image Acquisition System
In order to acquire quick, high resolution, affordable aerial photographs, an unmanned helium filled airship system equipped with a non-metric digital camera was developed in Chinese Academy of Surveying and M...
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Article
Two Anthraquinone Compounds from a Marine Actinomycete Isolate M097 Isolated from Jiaozhou Bay
Two anthraquinone compounds were isolated from the culture broth of a marine actinomycete isolate M097. The structures were elucidated as Aloesaponarin II and 1,6-dihydroxy-8-hydroxymethyl-anthraquinone by det...
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Article
Water-holding characteristics of litter in different forests at the Lianxiahe watershed
We surveyed the forest litter amount at the Lianxiahe watershed in the Three Gorges Reservoir Area and analyzed some hydrological characteristics such as the maximum water-holding capacity and water absorption...
