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  1. Article

    Open Access

    HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation

    Ultra-stable fibrous structure is a hallmark of amyloids. In contrast to canonical disease-related amyloids, emerging research indicates that a significant number of cellular amyloids, termed ‘functional amylo...

    Erpeng Wu, Wenyan He, Chenlu Wu, Zhangcheng Chen, Shijie Zhou, **alian Wu… in Cell Research (2023)

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  2. Article

    Open Access

    The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands

    Muscarinic acetylcholine receptors (mAChRs) respond to the neurotransmitter acetylcholine and play important roles in human nervous system. Muscarinic receptor 4 (M4R) is a promising drug target for treating n...

    **g**g Wang, Meng Wu, Zhangcheng Chen, Lijie Wu, Tian Wang… in Nature Communications (2022)

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    Article

    Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties

    Partial agonist activity at the dopamine D2 receptor (DRD2) is a key feature of third-generation antipsychotics (TGAs). However, TGAs also act as antagonists or weak partial agonists to the serotonin (5-hydroxytr...

    Zhangcheng Chen, Luyu Fan, Huan Wang, **g Yu, Dengyu Lu… in Nature Neuroscience (2022)

  4. Article

    Open Access

    Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands

    The D2 dopamine receptor (DRD2) is one of the most well-established therapeutic targets for neuropsychiatric and endocrine disorders. Most clinically approved and investigational drugs that target this receptor a...

    Luyu Fan, Liang Tan, Zhangcheng Chen, Jianzhong Qi, Fen Nie… in Nature Communications (2020)

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