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  1. Article

    Open Access

    Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis

    Primary sclerosing cholangitis (PSC) is an immune-mediated disease of the bile ducts that co-occurs with inflammatory bowel disease (IBD) in almost 90% of cases. Colorectal cancer is a major complication of pa...

    Dustin G. Shaw, Raúl Aguirre-Gamboa, Marcos C. Vieira, Saideep Gona… in Nature Medicine (2023)

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    Article

    Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host

    Somatic mutations in tet methylcytosine dioxygenase 2 (TET2), which encodes an epigenetic modifier enzyme, drive the development of haematopoietic malignancies1–7. In both humans and mice, TET2 deficiency leads t...

    Marlies Meisel, Reinhard Hinterleitner, Alain Pacis, Li Chen, Zachary M. Earley… in Nature (2018)