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  1. No Access

    Article

    Epithelial IFNγ signalling and compartmentalized antigen presentation orchestrate gut immunity

    All nucleated cells express major histocompatibility complex I and interferon‐γ (IFNγ) receptor1, but an epithelial cell-specific function of IFNγ signalling or antigen presentation by means of major histocompati...

    Ankit Malik, Deepika Sharma, Raúl Aguirre-Gamboa, Shaina McGrath, Sarah Zabala… in Nature (2023)

  2. Article

    Open Access

    Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis

    Primary sclerosing cholangitis (PSC) is an immune-mediated disease of the bile ducts that co-occurs with inflammatory bowel disease (IBD) in almost 90% of cases. Colorectal cancer is a major complication of pa...

    Dustin G. Shaw, Raúl Aguirre-Gamboa, Marcos C. Vieira, Saideep Gona… in Nature Medicine (2023)

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  3. Article

    Open Access

    Deconvolution of bulk blood eQTL effects into immune cell subpopulations

    Expression quantitative trait loci (eQTL) studies are used to interpret the function of disease-associated genetic risk factors. To date, most eQTL analyses have been conducted in bulk tissues, such as whole b...

    Raúl Aguirre-Gamboa, Niek de Klein, Jennifer di Tommaso… in BMC Bioinformatics (2020)

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