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  1. No Access

    Article

    The LexA–RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation

    The bacterial SOS response plays a key role in adaptation to DNA damage, including genomic stress caused by antibiotics. SOS induction begins when activated RecA*, an oligomeric nucleoprotein filament that for...

    Michael B. Cory, Allen Li, Christina M. Hurley… in Nature Structural & Molecular Biology (2024)

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    Article

    Mechanisms for targeted, purposeful mutation revealed in an APOBEC–DNA complex

    Targeted deamination of cytosine bases in DNA by AID/APOBEC-family enzymes is critical for proper immune function, but it also poses risks to genomic integrity. New structures reported by Harris, Aihara and co...

    Emily K Schutsky, Zachary M Hostetler… in Nature Structural & Molecular Biology (2017)