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Article
The LexA–RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation
The bacterial SOS response plays a key role in adaptation to DNA damage, including genomic stress caused by antibiotics. SOS induction begins when activated RecA*, an oligomeric nucleoprotein filament that for...
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Article
Open AccessInfluence of the amino-terminal sequence on the structure and function of HIV integrase
Antiretroviral therapy (ART) can mitigate the morbidity and mortality caused by the human immunodeficiency virus (HIV). Successful development of ART can be accelerated by accurate structural and biochemical d...
