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Article
Open AccessDetection of clonal plasma cells in POEMS syndrome using multiparameter flow cytometry
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein [M-protein], and skin changes) is a rare systemic disorder characterized by various symptoms caused by underlying plasma cell (P...
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Article
The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms
Dysfunctional anti-tumor immunity has been implicated in the pathogenesis of mature B cell neoplasms, such as multiple myeloma and B cell lymphoma; however, the impact of exhausted T cells on disease developme...
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Article
Open AccessThe combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells
The novel small molecule PTC596 inhibits microtubule polymerization and its clinical development has been initiated for some solid cancers. We herein investigated the preclinical efficacy of PTC596 alone and i...
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Article
Immunomodulator-associated Epstein–Barr virus-positive mucocutaneous ulcer in a patient with refractory Crohn’s disease
Epstein–Barr virus (EBV)-positive mucocutaneous ulcer is a B-cell lymphoproliferative disorder occurring in elderly or iatrogenic immunocompromised patients. We report a 27-year-old male patient with Crohn’s d...
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Article
Low incidence of thromboembolism in multiple myeloma patients receiving immunomodulatory drugs; a retrospective single-institution analysis
Anti-platelet agents or anticoagulants are administered for patients with multiple myeloma (MM) receiving immunomodulatory drugs (IMiDs) to prevent thrombotic events (TEs). However, there is a discrepancy betw...
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Article
Genetic and transcriptional landscape of plasma cells in POEMS syndrome
POEMS syndrome is a rare paraneoplastic disease associated with monoclonal plasma cells; however, the pathogenic importance of plasma cells remains unclear. We performed comprehensive genetic analyses of plasm...
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Article
Open AccessCyclosporine is a potential curative treatment option for advanced thymoma
Thymectomy can effectively cure most thymoma patients; however, patients with advanced thymoma typically require chemotherapy, which is associated with limited efficacy in this context. Here we provide the fir...
