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Article
Open AccessAdvancing Guideline-Directed Medical Therapy in Heart Failure: Overcoming Challenges and Maximizing Benefits
The delayed titration of guideline-directed drug therapy (GDMT) is a complex event influenced by multiple factors that often result in poor prognosis for patients with heart failure (HF). Individualized adjust...
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Article
Open AccessOvercoming barriers for left atrial appendage thrombus: a systematic review of left atrial appendage closure
Approximately 90% of intracardial thrombi originate from the left atrial appendage in non-valvular atrial fibrillation patients. Even with anticoagulant therapy, left atrial appendage thrombus (LAAT) still occ...
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Article
Open AccessAmino acid profile alteration in age-related atrial fibrillation
Amino acids (AAs) are one of the primary metabolic substrates for cardiac work. The correlation between AAs and both atrial fibrillation (AF) and aging has been documented. However, the relationship between AA...
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Article
Novel Drug Targets for Atrial Fibrillation Identified Through Mendelian Randomization Analysis of the Blood Proteome
Novel, effective, and safe preventive therapy targets for AF are still needed. Circulating proteins with causal genetic evidence are promising candidates. We aimed to systematically screen circulating proteins...
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Article
The impact of the establishment of carbon emission trade exchange on carbon emission efficiency
The China government focuses on changes in carbon emission efficiency with establishing carbon emission trade exchange (CETE). It is meaningful to study whether the pilot CETEs can facilitate the betterment of...
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Article
Open AccessThe desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53
Desmoglein-3 (Dsg3), the Pemphigus Vulgaris (PV) antigen (PVA), plays an essential role in keratinocyte cell–cell adhesion and regulates various signaling pathways involved in the progression and metastasis of ca...
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Article
Moderate alcohol consumption and atherosclerosis
Alcohol consumption plays an important role in the risk of major cardiovascular diseases. We conducted a meta-analysis to summarize the association between moderate alcohol consumption and atherosclerosis.
