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Article
The development and benefits of metformin in various diseases
Metformin has been used for the treatment of type II diabetes mellitus for decades due to its safety, low cost, and outstanding hypoglycemic effect clinically. The mechanisms underlying these benefits are comp...
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Article
Histone demethylase KDM5B licenses macrophage-mediated inflammatory responses by repressing Nfkbia transcription
Macrophages play a critical role in the immune homeostasis and host defense against invading pathogens. However, uncontrolled activation of inflammatory macrophages leads to tissue injury and even fuels autoim...
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Article
Open AccessPhosphorylation of PHF2 by AMPK releases the repressive H3K9me2 and inhibits cancer metastasis
Epithelial to mesenchymal transition (EMT) plays a crucial role in cancer metastasis, accompanied with vast epigenetic changes. AMP-activated protein kinase (AMPK), a cellular energy sensor, plays regulatory r...
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Chapter and Conference Paper
Researches on Control Strategy of Household Energy Based on Demand Response
The number of household appliances has increased rapidly in recent years. At the same time, photovoltaic and energy storage equipment in residential district are also widely used. The purpose of the paper is r...
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Article
Open AccessLoss of KDM5B ameliorates pathological cardiac fibrosis and dysfunction by epigenetically enhancing ATF3 expression
Excessive cardiac fibrosis is central to adverse cardiac remodeling and dysfunction leading to heart failure in many cardiac diseases. Histone methylation plays a crucial role in various pathophysiological eve...
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Article
KDM2B promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling
IL-6 plays important and pleiotropic roles in infection and inflammatory diseases, and its production needs to be tightly regulated. However, the epigenetic mechanism underlying Il6 gene transcription remains to ...
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Article
Methyltransferase Dot1l preferentially promotes innate IL-6 and IFN-β production by mediating H3K79me2/3 methylation in macrophages
Epigenetic modification, including histone modification, precisely controls target gene expression. The posttranscriptional regulation of the innate signaling-triggered production of inflammatory cytokines and...
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Article
Glycolipid iGb3 feedback amplifies innate immune responses via CD1d reverse signaling
The cross-talk between cellular lipid metabolism and the innate immune responses remains obscure. In addition to presenting lipid antigens to Natural Killer T-cells (NKT cells), the Cluster of Differentiation ...
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Article
Open AccessA novel chemotherapeutic sensitivity-testing system based on collagen gel droplet embedded 3D–culture methods for hepatocellular carcinoma
Patients suffering from advanced stage hepatocellular carcinoma (HCC) often exhibit a poor prognosis or dismal clinical outcomes due to ineffective chemotherapy or a multi-drug resistance (MDR) process. Thus, ...
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Article
Screening and Identification of a Fungal β-Glucosidase and the Enzymatic Synthesis of Gentiooligosaccharide
After screening with 0.1% esculoside and 0.03% FeCl3, we identified from rotten wood a fungal isolate HML0366 that produces high amount of β-glucosidase. Phenotypic and rDNA internal transcribed spacer sequence a...
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Article
Modeling and defending passive worms over unstructured peer-to-peer networks?
Passive worms can passively propagate through embedding themselves into some sharing files, which can result in significant damage to unstructured P2P networks. To study the passive worm behaviors, this paper ...
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Chapter and Conference Paper
Optimization of HDR Brachytherapy Treatment Plans
Purpose: Effective cancer brachytherapy requires a treatment plan that delivers high dose to tumor while minimizing dose to critical normal tissue. Current planning systems generate accurately ph...
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Chapter and Conference Paper
3D Display of Treatment Planning and Anatomy Data: Initial Observation Using a Promising Technical Advance
Purpose: To determine the feasibility of using a novel 3D display device for radiotherapy treatment planning and to provide guidelines for future development
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Chapter and Conference Paper
Worm Propagation Modeling and Analysis on Network
In recent years, network worms that had a dramatic increase in the frequency and virulence of such outbreaks have become one of the major threats to the security of the Internet. This paper provides a worm pro...
