-
Article
Open AccessTargeting NLRP3 signaling reduces myocarditis-induced arrhythmogenesis and cardiac remodeling
Myocarditis substantially increases the risk of ventricular arrhythmia. Approximately 30% of all ventricular arrhythmia cases in patients with myocarditis originate from the right ventricular outflow tract (RV...
-
Article
Open AccessEmpagliflozin suppressed cardiac fibrogenesis through sodium-hydrogen exchanger inhibition and modulation of the calcium homeostasis
The novel sodium-glucose co-transporter 2 inhibitor (SGLT2i) potentially ameliorates heart failure and reduces cardiac arrhythmia. Cardiac fibrosis plays a pivotal role in the pathophysiology of HF and atrial ...
-
Article
Open AccessCorrelation between short- and mid-term hemoglobin A1c and glycemic control determined by continuous glucose monitoring
Glucose monitoring is vital for glycemic control in patients with diabetes mellitus (DM). Continuous glucose monitoring (CGM) measures whole-day glucose levels. Hemoglobin A1c (HbA1c) is a vital outcome predic...
-
Article
Effect of antidiabetic drugs on the risk of atrial fibrillation: mechanistic insights from clinical evidence and translational studies
Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF), which is the most common sustained arrhythmia and is associated with substantial morbidity and mortality. Advanced glycation e...
-
Article
Concurrent increases in post-pacing action potential duration and contractility predict occurrence of ventricular arrhythmia
Excitation-contraction coupling from the integration of action potential duration (APD) and muscle contractility plays an important role in arrhythmogenesis. We aimed to determine whether distinctive excitatio...
-
Article
Open AccessArginine vasopressin modulates electrical activity and calcium homeostasis in pulmonary vein cardiomyocytes
Atrial fibrillation (AF) frequently coexists with congestive heart failure (HF) and arginine vasopressin (AVP) V1 receptor antagonists are used to treat hyponatremia in HF. However, the role of AVP in HF-induc...
-
Article
Open AccessCalcitriol downregulates fibroblast growth factor receptor 1 through histone deacetylase activation in HL-1 atrial myocytes
Fibroblast growth factor (FGF)-2 plays a crucial role in the pathophysiology of cardiovascular diseases (CVDs). FGF-2 was reported to induce cardiac hypertrophy through activation of FGF receptor 1 (FGFR1). Mu...
-
Article
Type A intramural hematoma and hemopericardium secondary to penetrating atherosclerotic ulcer
-
Article
Gender modulates the aging effects on different patterns of early repolarization
Distinct patterns of early repolarization (ER) are associated with ventricular fibrillation and arrhythmic death. We evaluated whether gender modulated the aging effects on different ER patterns. We studied ma...
-
Article
Open AccessLeptin modulates electrophysiological characteristics and isoproterenol-induced arrhythmogenesis in atrial myocytes
Obesity is an important risk factor for atrial fibrillation (AF). Leptin is an important adipokine. However, it is not clear whether leptin directly modulates the electrophysiological characteristics of atrial...
-
Article
Analysis of 10-year nationwide population-based data on sex differences in hospitalization for heart failure
Sex-related factors play an important role in the pathophysiology of heart failure (HF). However, trends in sex-related differences in hospital management for HF are not clear. We identified patients hospitali...
-
Article
Open AccessRivaroxaban modulates electrical and mechanical characteristics of left atrium
Rivaroxaban reduces stroke in patients with atrial fibrillation (AF). Left atrium (LA) plays a critical role in the pathophysiology of AF. However, the electromechanical effects of rivaroxaban on LA are not cl...
-
Article
Adipocytes modulate the electrophysiology of atrial myocytes: implications in obesity-induced atrial fibrillation
Obesity is an important risk factor for atrial fibrillation (AF). Increased epicardial adipose tissue in obesity can enhance inflammation and plays an important role in the pathophysiology of AF. However, it i...
-
Article
Electromechanical effects of the direct renin inhibitor (aliskiren) on the pulmonary vein and atrium
Activation of the atrial renin–angiotensin system plays an important role in the pathophysiology of atrial fibrillation (AF). The pulmonary vein (PV) and left atrium (LA) are important trigger and substrate fo...
-
Article
Discrepant electrophysiological characteristics and calcium homeostasis of left atrial anterior and posterior myocytes
The left atrial (LA) posterior wall has been demonstrated to have regional electrophysiological differences with a higher arrhythmogenic potential leading to atrial fibrillation (AF). However, the ionic charac...
-
Article
Open AccessNitroprusside modulates pulmonary vein arrhythmogenic activity
Pulmonary veins (PVs) are the most important sources of ectopic beats with the initiation of paroxysmal atrial fibrillation, or the foci of ectopic atrial tachycardia and focal atrial fibrillation. Elimination...
-
Article
Predictors of Early and Late Recurrence of Atrial Fibrillation after Catheter Ablation of Paroxysmal Atrial Fibrillation
Introduction: The outcome of patients with early recurrence of atrial fibrillation (AF) (within one month) after ablation procedure is controversial. Furthermore, the predictors of early and late (up to mean fol...
-
Article
Use of Fluoroscopic Views for Detecting Marshall's Vein in Patients with Cardiac Arrhythmias
Introduction: Recently, several studies showed that focal atrial fibrillation (AF) can be initiated by ectopic beats from the vein of Marshall (VOM). However, the incidence and best fluoroscopic views of VOM hav...
-
Article
Utility of Patient-Activated Cardiac Event Recorders in the Detection of Cardiac Arrhythmias
Background: Patient-activated event re- corders are useful for the diagnosis of arrhythmia in patients with palpitation and presyncope. However, the utility of event recorders in patients suspected of arrhythmia...
-
Article
Double Potential Interval and Transisthmus Conduction Time for Prediction of Cavotricuspid Isthmus Block after Ablation of Typical Atrial Flutter
Background: Complete bi-directional isthmus block is the endpoint of typical atrial flutter ablation. The purpose of this study was to investigate the feasibility of the local double potential (DP) interval and ...
